Resultats de la cerca - Nicholas Denko

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  1. 1
    Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth

    Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth per Ramon C. Sun, Nicholas Denko

    Publicat 2014
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  2. 2
    Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

    Hypoxia induces a novel signature of chromatin modifications and global repression of transcription per Amber Johnson, Nicholas Denko, Michelle Barton

    Publicat 2008
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  3. 3
    Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm?

    Anticancer drugs that target metabolism: Is dichloroacetate the new paradigm? per Ioanna Papandreou, Tereza Golias, Nicholas Denko

    Publicat 2010
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  4. 4
    Hypoxic Adaptation of Mitochondria and its Impact on Tumor Cell Function

    Hypoxic Adaptation of Mitochondria and its Impact on Tumor Cell Function per Martin Benej, Ioanna Papandreou, Nicholas Denko

    Publicat 2024
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  5. 5
    Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment

    Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment per Rob A. Cairns, Ioanna Papandreou, Nicholas Denko

    Publicat 2006
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  6. 6
    Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress

    Tumor Hypoxia Blocks Wnt Processing and Secretion through the Induction of Endoplasmic Reticulum Stress per Meletios Verras, Ioanna Papandreou, Ai Lin Lim, Nicholas Denko

    Publicat 2008
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  7. 7
    Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L

    Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L per Ioanna Papandreou, Ai Lin Lim, Keith R. Laderoute, Nicholas Denko

    Publicat 2008
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  8. 8
    Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy

    Metabolic targeting of hypoxia and HIF1 in solid tumors can enhance cytotoxic chemotherapy per Rob A. Cairns, Ioanna Papandreou, Patrick D. Sutphin, Nicholas Denko

    Publicat 2007
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  9. 9
    The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle.

    The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. per Nicholas Denko, Amato J. Giaccia, James R. Stringer, P J Stambrook

    Publicat 1994
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  10. 10
    Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α

    Role of Prolyl Hydroxylation in Oncogenically Stabilized Hypoxia-inducible Factor-1α per Denise A. Chan, Patrick D. Sutphin, Nicholas Denko, Amato J. Giaccia

    Publicat 2002
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  11. 11
    HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption

    HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption per Ioanna Papandreou, Rob A. Cairns, Lucrezia Fontana, Ai Lin Lim, Nicholas Denko

    Publicat 2006
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  12. 12
    Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect

    Oxygen Consumption Can Regulate the Growth of Tumors, a New Perspective on the Warburg Effect per Yijun Chen, Rob A. Cairns, Ioanna Papandreou, Albert C. Koong, Nicholas Denko

    Publicat 2009
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  13. 13
    Hypoxia Links ATR and p53 through Replication Arrest

    Hypoxia Links ATR and p53 through Replication Arrest per Ester M. Hammond, Nicholas Denko, Mary J. Dorie, Robert T. Abraham, Amato J. Giaccia

    Publicat 2002
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  14. 14
    Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment

    Anoxia Is Necessary for Tumor Cell Toxicity Caused by a Low-Oxygen Environment per Ioanna Papandreou, C. H. Ravi Krishna, Fiona Kaper, Deli Cai, Amato J. Giaccia, Nicholas Denko

    Publicat 2005
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  15. 15
    HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors

    HILPDA Regulates Lipid Metabolism, Lipid Droplet Abundance, and Response to Microenvironmental Stress in Solid Tumors per Matthew J. VandeKopple, Jinghai Wu, Erich N. Auer, Amato J. Giaccia, Nicholas Denko, Ioanna Papandreou

    Publicat 2019
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  16. 16
    Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth

    Imaging the Unfolded Protein Response in Primary Tumors Reveals Microenvironments with Metabolic Variations that Predict Tumor Growth per Michael T. Spiotto, Alice Banh, Ioanna Papandreou, Hongbin Cao, Michael G. Galvez, Geoffrey C. Gurtner, Nicholas Denko, Quynh‐Thu Le, Albert C. Koong

    Publicat 2009
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  17. 17
    Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma

    Histology-Based Expression Profiling Yields Novel Prognostic Markers in Human Glioblastoma per Shumin Dong, Catherine L. Nutt, Rebecca A. Betensky, Anat Stemmer‐Rachamimov, Nicholas Denko, Keith L. Ligon, David H. Rowitch, David N. Louis

    Publicat 2005
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  18. 18
    Identification of a Protein Mediating Respiratory Supercomplex Stability

    Identification of a Protein Mediating Respiratory Supercomplex Stability per Yu-Chan Chen, Eric B. Taylor, Noah Dephoure, Jin-Mi Heo, Aline Tonhato, Ioanna Papandreou, Nandita Nath, Nicholas Denko, Steven P. Gygi, Jared Rutter

    Publicat 2012
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  19. 19
    5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors

    5′-AMP-activated Protein Kinase (AMPK) Supports the Growth of Aggressive Experimental Human Breast Cancer Tumors per Keith R. Laderoute, Joy M. Calaoagan, Wan‐Ru Chao, Dominc Dinh, Nicholas Denko, Sarah Duellman, Jessica Kalra, Xiaohe Liu, Ioanna Papandreou, Lidia Sambucetti, László G. Boros

    Publicat 2014
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  20. 20
    Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway

    Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway per Kurosh Ameri, Ester M. Hammond, Carsten Culmsee, Martin Kristian Raida, Dörthe M. Katschinski, Roland H. Wenger, Ernst Wagner, Roger J. Davis, T Hai, Nicholas Denko, Adrian L. Harris

    Publicat 2006
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