Search Results - Nello Mainolfi

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  1. 1
    Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma

    Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma by Gregory S. Ducker, Jonathan M. Ghergurovich, Nello Mainolfi, Vipin Suri, Stephanie Jeong, Hsin‐Jung Li, Adam Friedman, Mark Manfredi, Zemer Gitai, Hahn Kim, Joshua D. Rabinowitz

    Published 2017
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  2. 2
    Serine Metabolism Supports Macrophage IL-1β Production

    Serine Metabolism Supports Macrophage IL-1β Production by Arianne E Rodriguez, Gregory S. Ducker, Leah K. Billingham, Carlos A. Martínez, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Samuel E. Weinberg, Joshua D. Rabinowitz, Navdeep S. Chandel

    Published 2019
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  3. 3
    Serine Is an Essential Metabolite for Effector T Cell Expansion

    Serine Is an Essential Metabolite for Effector T Cell Expansion by H. Eric, Glenn R. Bantug, Takla Griss, Stephanie A. Condotta, Radia Marie Johnson, Bożena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L. Balmer, Mark Verway, Thomas C. Raissi, Harmony Tsui, Giselle M. Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M. Krawczyk, Adam Friedman, Mark Manfredi, Martin J. Richer, Christoph Hess, Russell G. Jones

    Published 2017
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  4. 4
    Serine Is an Essential Metabolite for Effector T Cell Expansion

    Serine Is an Essential Metabolite for Effector T Cell Expansion by H. Eric, Glenn R. Bantug, Takla Griss, Stephanie A. Condotta, Radia Marie Johnson, Bożena Samborska, Nello Mainolfi, Vipin Suri, Hannah Guak, Maria L. Balmer, Mark Verway, Thomas C. Raissi, Harmony Tsui, Giselle M. Boukhaled, Sofia Henriques da Costa, Christian Frezza, Connie M. Krawczyk, Adam Friedman, Mark Manfredi, Martin J. Richer, Christoph Hess, Russell G. Jones

    Published 2017
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  5. 5
    Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy

    Serine synthesis pathway inhibition cooperates with dietary serine and glycine limitation for cancer therapy by Mylène Tajan, Marc Hennequart, Eric C. Cheung, Fabio Zani, Andreas Hock, Nathalie Legrave, Oliver D.K. Maddocks, Rachel A. Ridgway, Dimitris Athineos, Alejandro Suárez‐Bonnet, Robert L. Ludwig, Laura Novellasdemunt, Nikolaos Angelis, Vivian Li, Georgios Vlachogiannis, Nicola Valeri, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, Karen Blyth, Owen J. Sansom, Karen H. Vousden

    Published 2021
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  6. 6
    Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases

    Discovery of KT-474─a Potent, Selective, and Orally Bioavailable IRAK4 Degrader for the Treatment of Autoimmune Diseases by Xiaozhang Zheng, Nan Ji, Veronica A. Campbell, Anthony Slavin, Xiao Zhu, Dapeng Chen, Haojing Rong, B. Enerson, Michele Mayo, Kirti Sharma, C. Browne, Christine R. Klaus, Haoran Li, Ginny Massa, Alice McDonald, Yatao Shi, Mike Sintchak, Stephanie Skouras, Dirk Walther, Karen Yuan, Yi Zhang, Joe Kelleher, Guang Liu, Xinbo Luo, Nello Mainolfi, Matthew M. Weiss

    Published 2024
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  7. 7
    IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial

    IRAK4 degrader in hidradenitis suppurativa and atopic dermatitis: a phase 1 trial by Lindsay Ackerman, Gerard Acloque, Sandro Bacchelli, Howard J. Schwartz, Brian Feinstein, Phillip La Stella, Afsáneh Alavi, Ashwin Gollerkeri, Jeffrey Davis, Veronica A. Campbell, Alice McDonald, Sagar Agarwal, Rahul Karnik, Kelvin Shi, Aimee Mishkin, Jennifer Culbertson, Christine R. Klaus, Bradley Enerson, Virginia Massa, Eric Kuhn, Kirti Sharma, Erin P. Keaney, R. M. Barnes, Dapeng Chen, Xiaozhang Zheng, Haojing Rong, Vijay Sabesan, Chris Ho, Nello Mainolfi, Anthony Slavin, Jared Gollob

    Published 2023
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  8. 8
    Small-molecule factor B inhibitor for the treatment of complement-mediated diseases

    Small-molecule factor B inhibitor for the treatment of complement-mediated diseases by Anna Schubart, Karen Anderson, Nello Mainolfi, Holger Sellner, Takeru Ehara, Christopher M. Adams, Aengus Mac Sweeney, Sha-Mei Liao, Maura Crowley, Amanda Littlewood‐Evans, Sophie Sarret, Grazyna Wieczorek, Ludovic Perrot, Valérie Dubost, Thierry Flandre, Yuzhou Zhang, Richard J. Smith, Antonio M. Risitano, Rajeshri G. Karki, Chun Zhang, Eric Valeur, Finton Sirockin, Bernd Gerhartz, P. Erbel, Nicola Hughes, Thomas M. Smith, Frédéric Cumin, Upendra A. Argikar, Börje Haraldsson, Muneto Mogi, Richard Sedrani, Christian Wiesmann, Bruce Jaffee, Jürgen Maibaum, Stefanie Flohr, R. A. Harrison, Jörg Eder

    Published 2019
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  9. 9
    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

    Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition by Bryan Ngo, Eugenie Kim, Victoria Osorio-Vasquez, Sophia Doll, Sophia Bustraan, Roger J. Liang, Alba Luengo, Shawn M. Davidson, Ahmed Ali, Gino B. Ferraro, Grant M. Fischer, Roozbeh Eskandari, Diane S. Kang, Jing Ni, Ariana Plasger, Vinagolu K. Rajasekhar, Edward R. Kastenhuber, Sarah Bacha, Roshan K. Sriram, Benjamin D. Stein, Samuel F. Bakhoum, Matija Snuderl, Paolo Cotzia, John H. Healey, Nello Mainolfi, Vipin Suri, Adam Friedman, Mark Manfredi, David M. Sabatini, Drew R. Jones, Min Yu, Jean J. Zhao, Rakesh K. Jain, Kayvan R. Keshari, Michael A. Davies, Matthew G. Vander Heiden, Eva Hernando, Matthias Mann, Lewis C. Cantley, Michael E. Pacold

    Published 2020
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