Search Results - Neil R. Kitteringham

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  1. 1
    Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity

    Cellular disposition of sulphamethoxazole and its metabolites: implications for hypersensitivity by Dean J. Naisbitt, Sally Hough, Helen Gill, Munir Pirmohamed, Neil R. Kitteringham, B. Kevin Park

    Published 1999
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  2. 2
    Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i>

    Characterisation of flucloxacillin and 5‐hydroxymethyl flucloxacillin haptenated HSA <i>in vitro</i> and <i>in vivo</i> by Rosalind E. Jenkins, Xiaoli Meng, Victoria L. Elliott, Neil R. Kitteringham, Munir Pirmohamed, B. Kevin Park

    Published 2009
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  3. 3
    Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione <i>S</i> -transferase Pi

    Increased resistance to acetaminophen hepatotoxicity in mice lacking glutathione <i>S</i> -transferase Pi by Colin J. Henderson, C. Roland Wolf, Neil R. Kitteringham, Helen Powell, Diana M. E. Otto, B. Kevin Park

    Published 2000
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  4. 4
    Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi

    Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi by Robert Elsby, Neil R. Kitteringham, Christopher E. Goldring, Cerys Lovatt, M. Chamberlain, Colin J. Henderson, C. Roland Wolf, B. Kevin Park

    Published 2003
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  5. 5
    High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo

    High-Mobility Group Box-1 Protein and Keratin-18, Circulating Serum Proteins Informative of Acetaminophen-Induced Necrosis and Apoptosis In Vivo by Daniel J. Antoine, Dominic P. Williams, Anja Kipar, Rosalind E. Jenkins, Sophie Regan, Jean G. Sathish, Neil R. Kitteringham, B. Kevin Park

    Published 2009
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  6. 6
    Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening

    Generating hepatic cell lineages from pluripotent stem cells for drug toxicity screening by M. Baxter, Cliff Rowe, Jane Alder, Sean Harrison, Karen Piper Hanley, B. Kevin Park, Neil R. Kitteringham, Christopher E. Goldring, Neil A. Hanley

    Published 2010
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  7. 7
    Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet?

    Stem cell‐derived hepatocytes as a predictive model for drug‐induced liver injury: are we there yet? by Richard Kia, Rowena L. C. Sison, James A. Heslop, Neil R. Kitteringham, Neil A. Hanley, John Mills, B. Kevin Park, Christopher E. Goldring

    Published 2012
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  8. 8
    Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway

    Physical and Functional Interaction of Sequestosome 1 with Keap1 Regulates the Keap1-Nrf2 Cell Defense Pathway by Ian M. Copple, Adam Lister, Akua D. Obeng, Neil R. Kitteringham, Rosalind E. Jenkins, Robert Layfield, Brian Foster, Christopher E. Goldring, B. Kevin Park

    Published 2010
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  9. 9
    Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation

    Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation by Mingzhan Xue, Naila Rabbani, Hiroshi Momiji, Precious Imbasi, M. Maqsud Anwar, Neil R. Kitteringham, B. Kevin Park, Tomokazu Souma, Takashi Moriguchi, Masayuki Yamamoto, Paul J. Thornalley

    Published 2011
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  10. 10
    Proteome‐wide analyses of human hepatocytes during differentiation and dedifferentiation

    Proteome‐wide analyses of human hepatocytes during differentiation and dedifferentiation by Cliff Rowe, Dave T. Gerrard, Roz Jenkins, Andrew Berry, Kesta Durkin, Lars Sundström, Christopher E. Goldring, B. Kevin Park, Neil R. Kitteringham, Karen Piper Hanley, Neil A. Hanley

    Published 2013
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  11. 11
    Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice

    Activation of hepatic Nrf2in vivo by acetaminophen in CD-1 mice by Christopher E. Goldring, Neil R. Kitteringham, Robert Elsby, Laura E. Randle, Y Clément, Dominic P. Williams, Michael McMahon, John D. Hayes, Ken Itoh, Masayuki Yamamoto, Kevin B. Park

    Published 2004
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  12. 12
    Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signaling in Dendritic Cells

    Loss of Transcription Factor Nuclear Factor-Erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Leads to Dysregulation of Immune Functions, Redox Homeostasis, and Intracellular Signali... by Han Xian Aw Yeang, Junnat Hamdam, Laith M Abbas Al-Huseini, Swaminathan Sethu, Laiche Djouhri, Joanne Walsh, Neil R. Kitteringham, B. Kevin Park, Christopher E. Goldring, Jean G. Sathish

    Published 2012
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  13. 13
    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy

    Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy by Adam Lister, Taoufik Nedjadi, Neil R. Kitteringham, Fiona Campbell, Eithne Costello, Bryony H. Lloyd, Ian M. Copple, Samantha Williams, Andrew Owen, John P. Neoptolemos, Christopher E. Goldring, B. Kevin Park

    Published 2011
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  14. 14
    Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications

    Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: Biochemical, pharmacological and toxicological implications by Joanne Walsh, Rosalind E. Jenkins, Michael H. L. Wong, T.M.A. Olayanju, Helen Powell, Ian M. Copple, Paul M. O’Neill, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park

    Published 2014
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  15. 15
    Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activating Transcription Factor 1 Signaling

    Nuclear Factor-erythroid 2 (NF-E2) p45-related Factor-2 (Nrf2) Modulates Dendritic Cell Immune Function through Regulation of p38 MAPK-cAMP-responsive Element Binding Protein/Activ... by Laith M Abbas Al-Huseini, Han Xian Aw Yeang, Swaminathan Sethu, Naif Alhumeed, Junnat Hamdam, Yulia Tingle, Laiche Djouhri, Neil R. Kitteringham, B. Kevin Park, Christopher E. Goldring, Jean G. Sathish

    Published 2013
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  16. 16
    Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites

    Design and Synthesis of Irreversible Analogues of Bardoxolone Methyl for the Identification of Pharmacologically Relevant Targets and Interaction Sites by Michael H. L. Wong, Holly K. Bryan, Ian M. Copple, Rosalind E. Jenkins, Pak Him Chiu, Jaclyn Bibby, Neil G. Berry, Neil R. Kitteringham, Christopher E. Goldring, Paul M. O’Neill, B. Kevin Park

    Published 2016
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  17. 17
    Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and Detoxication

    Comparative Proteomic Characterization of 4 Human Liver-Derived Single Cell Culture Models Reveals Significant Variation in the Capacity for Drug Disposition, Bioactivation, and De... by Rowena Sison‐Young, Dimitra Mitsa, Rosalind E. Jenkins, David R. Mottram, Eliane Alexandre, Lysiane Richert, Hélène Aerts, Richard Weaver, Robert Jones, Esther Johann, Philip Hewitt, Magnus Ingelman‐Sundberg, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park

    Published 2015
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  18. 18
    Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver

    Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver by Neil R. Kitteringham, Azman Abdullah, Joanne Walsh, Laura E. Randle, Rosalind E. Jenkins, Rowena L. C. Sison, Christopher E. Goldring, Helen Powell, Christopher M. Sanderson, Samantha Williams, Larry G. Higgins, Masayuki Yamamoto, John D. Hayes, B. Kevin Park

    Published 2010
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  19. 19
    Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile

    Mechanistic evaluation of primary human hepatocyte culture using global proteomic analysis reveals a selective dedifferentiation profile by James A. Heslop, Cliff Rowe, Joanne Walsh, Rowena Sison‐Young, Roz Jenkins, Laleh Kamalian, Richard Kia, David C. Hay, Robert Jones, Hassan Malik, Stephen W. Fenwick, Amy E. Chadwick, John Mills, Neil R. Kitteringham, Christopher E. Goldring, B. Kevin Park

    Published 2016
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  20. 20
    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer

    The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer by Jonathan Evans, Bolesław Winiarski, Paul Sutton, Robert Jones, Lorenzo Ressel, Carrie A. Duckworth, D. Mark Pritchard, Zhi‐Xiu Lin, Vicky L. Fretwell, E Tweedle, Eithne Costello, Christopher E. Goldring, Ian M. Copple, B. Kevin Park, Daniel H. Palmer, Neil R. Kitteringham

    Published 2018
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