檢索結果 - Neil MacLean

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  1. 1
    RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs

    RB1 Status in Triple Negative Breast Cancer Cells Dictates Response to Radiation Treatment and Selective Therapeutic Drugs 由 Tyler Robinson, Jeff C. Liu, Frederick S. Vizeacoumar, Thomas Sun, Neil MacLean, Sean E. Egan, Aaron D. Schimmer, Alessandro Datti, Eldad Zacksenhaus

    出版 2013
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  2. 2
    A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity

    A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity 由 Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu Emily Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al‐awar, Aaron D. Schimmer

    出版 2021
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  3. 3
    Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML

    Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML 由 Sanduni U. Liyanage, Rose Hurren, Véronique Voisin, Gaëlle Bridon, Xiaoming Wang, Changjiang Xu, Neil MacLean, Thirushi Siriwardena, Marcela Gronda, Dana Yehudai, Shrivani Sriskanthadevan, Daina Avizonis, Aisha Shamas‐Din, Mark D. Minden, Gary D. Bader, Rebecca R. Laposa, Aaron D. Schimmer

    出版 2017
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  4. 4
    Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production

    Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production 由 Jong Bok Lee, Dilshad H. Khan, Rose Hurren, Mingjing Xu, Yoosu Na, Hyeonjeong Kang, Sara Mirali, Xiaoming Wang, Marcela Gronda, Yulia Jitkova, Neil MacLean, Andrea Arruda, Zoe Alaniz, Marina Konopleva, Michael Andreeff, Mark D. Minden, Zhang Li, Aaron D. Schimmer

    出版 2021
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  5. 5
    Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands

    Selective Inhibition of Histone Deacetylases Sensitizes Malignant Cells to Death Receptor Ligands 由 Tabitha E. Wood, Shadi Dalili, Craig D. Simpson, Mahadeo A. Sukhai, Rose Hurren, Kika Anyiwe, Xinliang Mao, Fernando Suárez, Marcela Gronda, Yanina Eberhard, Neil MacLean, Troy Ketela, John C. Reed, Jason Moffat, Mark D. Minden, Robert A. Batey, Aaron D. Schimmer

    出版 2010
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  6. 6
    The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

    The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma 由 G. Wei Xu, Mohsin Ali, Tabitha E. Wood, Derek Wong, Neil MacLean, Xiaoming Wang, Marcela Gronda, Marko Škrtić, Xiaoming Li, Rose Hurren, Xinliang Mao, Meenakshi Venkatesan, Reza Beheshti Zavareh, Troy Ketela, John C. Reed, David R. Rose, Jason Moffat, Robert A. Batey, Sirano Dhe‐Paganon, Aaron D. Schimmer

    出版 2010
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  7. 7
    The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

    The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability 由 Sara Mirali, Aaron Botham, Véronique Voisin, Changjiang Xu, Jonathan St‐Germain, David Sharon, Fieke W. Hoff, Yihua Qiu, Rose Hurren, Marcela Gronda, Yulia Jitkova, Boaz Nachmias, Neil MacLean, Xiaoming Wang, Andrea Arruda, Mark D. Minden, Terzah M. Horton, Steven M. Kornblau, Steven M. Chan, Gary D. Bader, Brian Raught, Aaron D. Schimmer

    出版 2020
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  8. 8
    AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

    AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress 由 Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy Chung, Swayam Prabha, Wei Xu, Marko Škrtić, Bozhena Jhas, Rose Hurren, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, Mahadeo A. Sukhai, Feng-Hsu Lin, Neil MacLean, Rob C. Laister, Carolyn A. Goard, Peter Mullen, Stephanie Z. Xie, Linda Z. Penn, Ian M. Rogers, John E. Dick, Mark D. Minden, Aaron D. Schimmer

    出版 2015
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  9. 9
    Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal

    Disrupting Mitochondrial Copper Distribution Inhibits Leukemic Stem Cell Self-Renewal 由 Rashim Pal Singh, Danny V. Jeyaraju, Véronique Voisin, Rose Hurren, Changjiang Xu, James R. Hawley, Samir H. Barghout, Dilshad H. Khan, Marcela Gronda, Xiaoming Wang, Yulia Jitkova, David Sharon, Sanduni Liyanagae, Neil MacLean, Ayesh K. Seneviratene, Sara Mirali, Adina Borenstein, Geethu Emily Thomas, Joelle Soriano, Elias Orouji, Mark D. Minden, Andrea Arruda, Steven M. Chan, Gary D. Bader, Mathieu Lupien, Aaron D. Schimmer

    出版 2020
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  10. 10
    Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia 由 Marko Škrtić, Shrivani Sriskanthadevan, Bozhena Jhas, Marinella Gebbia, Xiaoming Wang, Zezhou Wang, Rose Hurren, Yulia Jitkova, Marcela Gronda, Neil MacLean, Courteney K. Lai, Yanina Eberhard, Justyna Bartoszko, Paul A. Spagnuolo, Angela C. Rutledge, Alessandro Datti, Troy Ketela, Jason Moffat, Brian H. Robinson, Jessie Cameron, Jeffery L. Wrana, Connie J. Eaves, Mark D. Minden, Jean Wang, John E. Dick, R. Keith Humphries, Corey Nislow, Guri Giaever, Aaron D. Schimmer

    出版 2011
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  11. 11
    The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness

    The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness 由 Geethu Emily Thomas, Grace Egan, Laura García‐Prat, Aaron Botham, Véronique Voisin, Parasvi S. Patel, Fieke W. Hoff, J Chin, Boaz Nachmias, Kerstin B. Kaufmann, Dilshad H. Khan, Rose Hurren, Xiaoming Wang, Marcela Gronda, Neil MacLean, Cristiana O’Brien, Rashim Pal Singh, Courtney L. Jones, Shane M. Harding, Brian Raught, Andrea Arruda, Mark D. Minden, Gary D. Bader, Razqallah Hakem, Steve Kornblau, John E. Dick, Aaron D. Schimmer

    出版 2022
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  12. 12
    Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

    Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality 由 Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, Ondrej Halgas, Takenobu Nii, Yulia Jitkova, Ran Zhao, Jonathan St‐Germain, Lauren Heese, Grace Egan, Vivian Ruvolo, Samir H. Barghout, Yuki Nishida, Rose Hurren, Wencai Ma, Marcela Gronda, Todd Link, Keith S. Wong, Mark Mabanglo, Kensuke Kojima, Gautam Borthakur, Neil MacLean, Man Chun John, Andrew B. Leber, Mark D. Minden, Walid A. Houry, Hagop M. Kantarjian, Martin Stogniew, Brian Raught, E.F. Pai, Aaron D. Schimmer, Michael Andreeff

    出版 2019
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  13. 13
    Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors

    Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors 由 Mahadeo A. Sukhai, Swayam Prabha, Rose Hurren, Angela C. Rutledge, Anna Y. Lee, Shrivani Sriskanthadevan, Hong Sun, Xiaoming Wang, Marko Škrtić, Ayesh K. Seneviratne, Maria C. Cusimano, Bozhena Jhas, Marcela Gronda, Neil MacLean, Eunice E. Cho, Paul A. Spagnuolo, Sumaiya Sharmeen, Marinella Gebbia, Malene L. Urbanus, Kolja Eppert, Dilan Dissanayake, Alexia Jonet, Alexandra Dassonville‐Klimpt, Xiaoming Li, Alessandro Datti, Pamela S. Ohashi, Jeffrey L. Wrana, Ian M. Rogers, Pascal Sonnet, William Y. Ellis, Seth J. Corey, Connie J. Eaves, Mark D. Minden, Jean Wang, John E. Dick, Corey Nislow, Guri Giaever, Aaron D. Schimmer

    出版 2012
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  14. 14
    Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia 由 Alicia M. Cole, Zezhou Wang, Étienne Coyaud, Véronique Voisin, Marcela Gronda, Yulia Jitkova, Rachel Mattson, Rose Hurren, Sonja Babovic, Neil MacLean, Ian J. Restall, Xiaoming Wang, Danny V. Jeyaraju, Mahadeo A. Sukhai, Swayam Prabha, Shaheena Bashir, Ashwin Ramakrishnan, Elisa Leung, Yi Hua Qia, Nianxian Zhang, Kevin R. Combes, Troy Ketela, Fengshu Lin, Walid A. Houry, Ahmed Aman, Rima Al‐awar, Wei Zheng, Erno Wienholds, Chang Xu, John E. Dick, Jean Wang, Jason Moffat, Mark D. Minden, Connie J. Eaves, Gary D. Bader, Zhenyue Hao, Steven M. Kornblau, Brian Raught, Aaron D. Schimmer

    出版 2015
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  15. 15
    The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids

    The Mitochondrial Transacylase, Tafazzin, Regulates AML Stemness by Modulating Intracellular Levels of Phospholipids 由 Ayesh K. Seneviratne, Mingjing Xu, Juan J. Aristizabal Henao, Val A. Fajardo, Zhenyue Hao, Véronique Voisin, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny V. Jeyaraju, Yulia Jitkova, Troy Ketela, Michael Mullokandov, David Sharon, Geethu Emily Thomas, Raphaël Chouinard‐Watkins, James R. Hawley, Caitlin Schafer, Helen Loo Yau, Zaza Khuchua, Ahmed Aman, Rima Al‐awar, Atan Gross, Steven M. Claypool, Richard P. Bazinet, Mathieu Lupien, Steven M. Chan, Daniel D. De Carvalho, Mark D. Minden, Gary D. Bader, Ken D. Stark, Paul J. LeBlanc, Aaron D. Schimmer

    出版 2019
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