Resultats de la cerca - Nathaniel I. Martin

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  1. 1
    The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry

    The calcium-dependent lipopeptide antibiotics: structure, mechanism, & medicinal chemistry per Thomas M. Wood, Nathaniel I. Martin

    Publicat 2019
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  2. 2
    Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023

    Recent Advances in the Development of Polymyxin Antibiotics: 2010–2023 per Cornelis J. Slingerland, Nathaniel I. Martin

    Publicat 2024
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  3. 3
    Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics

    Synergy by Perturbing the Gram-Negative Outer Membrane: Opening the Door for Gram-Positive Specific Antibiotics per Charlotte M. J. Wesseling, Nathaniel I. Martin

    Publicat 2022
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  4. 4
    Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II

    Hit 'em where it hurts: The growing and structurally diverse family of peptides that target lipid-II per Sabine F. Oppedijk, Nathaniel I. Martin, Eefjan Breukink

    Publicat 2015
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  5. 5
    β-lactam/β-lactamase inhibitor combinations: an update

    β-lactam/β-lactamase inhibitor combinations: an update per Kamaleddin H. M. E. Tehrani, Nathaniel I. Martin

    Publicat 2018
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  6. 6
    Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target

    Nicotinamide N-methyl transferase (NNMT): An emerging therapeutic target per Yongzhi Gao, Nathaniel I. Martin, Matthijs J. van Haren

    Publicat 2021
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  7. 7
    Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases

    Small molecule inhibitors of histone acetyltransferases and deacetylases are potential drugs for inflammatory diseases per Frank J. Dekker, Thea van den Bosch, Nathaniel I. Martin

    Publicat 2013
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  8. 8
    Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption

    Polymyxin Stereochemistry and Its Role in Antibacterial Activity and Outer Membrane Disruption per Cornelis J. Slingerland, Ioli Kotsogianni, Charlotte M. J. Wesseling, Nathaniel I. Martin

    Publicat 2022
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  9. 9
    A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide <i>N</i>-Methyltransferase

    A Rapid and Efficient Assay for the Characterization of Substrates and Inhibitors of Nicotinamide <i>N</i>-Methyltransferase per Matthijs J. van Haren, Javier Sastre Toraño, Davide Sartini, Monica Emanuelli, Richard B. Parsons, Nathaniel I. Martin

    Publicat 2016
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  10. 10
    Specificity of the Transport of Lipid II by FtsW in Escherichia coli

    Specificity of the Transport of Lipid II by FtsW in Escherichia coli per Tamimount Mohammadi, Robert Sijbrandi, Mandy Lutters, Jolanda Verheul, Nathaniel I. Martin, Tanneke den Blaauwen, Ben de Kruijff, Eefjan Breukink

    Publicat 2014
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  11. 11
    Isolation, Structural Characterization, and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced byPaenibacillus kobensis M

    Isolation, Structural Characterization, and Properties of Mattacin (Polymyxin M), a Cyclic Peptide Antibiotic Produced byPaenibacillus kobensis M per Nathaniel I. Martin, Hai-Jing Hu, Matthew M. Moake, John J. Churey, Randy M. Whittal, Randy W. Worobo, John C. Vederas

    Publicat 2003
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  12. 12
    Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics

    Complement-dependent outer membrane perturbation sensitizes Gram-negative bacteria to Gram-positive specific antibiotics per Dani A. C. Heesterbeek, Nathaniel I. Martin, A. Velthuizen, Maxime Duijst, Maartje Ruyken, Richard Wubbolts, Suzan H. M. Rooijakkers, Bart W. Bardoel

    Publicat 2019
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  13. 13
    Exploring the Chemical Space of <i>Paenibacillus</i> NRPs and Discovery of Paenilipoheptin B

    Exploring the Chemical Space of <i>Paenibacillus</i> NRPs and Discovery of Paenilipoheptin B per Nataliia V. Machushynets, Vladyslav Lysenko, Chao Du, Cornelis J. Slingerland, Somayah S. Elsayed, Mark R. Liles, Nathaniel I. Martin, Gilles P. van Wezel

    Publicat 2025
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  14. 14
    Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action

    Total Synthesis of Laspartomycin C and Characterization of Its Antibacterial Mechanism of Action per Laurens H. J. Kleijn, Sabine F. Oppedijk, Peter ‘t Hart, Roel M. van Harten, Leah A. Martin‐Visscher, Johan Kemmink, Eefjan Breukink, Nathaniel I. Martin

    Publicat 2016
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  15. 15
    Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state

    Inhibitors of nicotinamide N-methyltransferase designed to mimic the methylation reaction transition state per Matthijs J. van Haren, Rebecca Taig, Jilles Kuppens, Javier Sastre Toraño, Ed E. Moret, Richard B. Parsons, Davide Sartini, Monica Emanuelli, Nathaniel I. Martin

    Publicat 2017
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  16. 16
    The kinetic analysis of the N -methylation of 4-phenylpyridine by nicotinamide N -methyltransferase: Evidence for a novel mechanism of substrate inhibition

    The kinetic analysis of the N -methylation of 4-phenylpyridine by nicotinamide N -methyltransferase: Evidence for a novel mechanism of substrate inhibition per Matthijs J. van Haren, Martin G. Thomas, Davide Sartini, David J. Barlow, D. Ramsden, Monica Emanuelli, Fábio Klamt, Nathaniel I. Martin, Richard B. Parsons

    Publicat 2018
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  17. 17
    Dual targeting of the class V lanthipeptide antibiotic cacaoidin

    Dual targeting of the class V lanthipeptide antibiotic cacaoidin per Julia P. Deisinger, Melina Arts, Ioli Kotsogianni, Jan-Samuel Puls, Fabian Grein, Francisco Javier Ortiz‐López, Nathaniel I. Martin, Anna Müller, Olga Genilloud, Tanja Schneider

    Publicat 2023
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  18. 18
    Bisubstrate Inhibitors of Nicotinamide <i>N</i>-Methyltransferase (NNMT) with Enhanced Activity

    Bisubstrate Inhibitors of Nicotinamide <i>N</i>-Methyltransferase (NNMT) with Enhanced Activity per Yongzhi Gao, Matthijs J. van Haren, Ed E. Moret, Johannes J.M. Rood, Davide Sartini, Alessia Salvucci, Monica Emanuelli, Pierrick Craveur, Nicolas Babault, Jian Jin, Nathaniel I. Martin

    Publicat 2019
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  19. 19
    Nicotinamide <i>N</i>-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway

    Nicotinamide <i>N</i>-methyltransferase catalyses the N-methylation of the endogenous β-carboline norharman: evidence for a novel detoxification pathway per Martin G. Thomas, Davide Sartini, Monica Emanuelli, Matthijs J. van Haren, Nathaniel I. Martin, David M. Mountford, David J. Barlow, Fábio Klamt, D. Ramsden, Madeehah Reza, Richard B. Parsons

    Publicat 2016
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  20. 20
    Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity

    Esterase-Sensitive Prodrugs of a Potent Bisubstrate Inhibitor of Nicotinamide N-Methyltransferase (NNMT) Display Cellular Activity per Matthijs J. van Haren, Yongzhi Gao, Ned Buijs, Roberto Campagna, Davide Sartini, Monica Emanuelli, Łukasz Mateuszuk, Agnieszka Kij, Stefan Chłopicki, Pol Escudé Martinez de Castilla, Raymond M. Schiffelers, Nathaniel I. Martin

    Publicat 2021
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