检索结果 - Muthusamy Jayaraman

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  1. 1
    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides

    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides 由 Alexander V. Kel’in, Ivan Zlatev, Joel M. Harp, Muthusamy Jayaraman, Anna Bisbe, Jonathan O′Shea, Nate Taneja, Rajar M. Manoharan, Saeed I. Khan, Klaus Charissé, Martin A. Maier, Martin Egli, Kallanthottathil G. Rajeev, Muthiah Manoharan

    出版 2016
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  2. 2
    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver 由 Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson

    出版 2009
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    Artigo
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  3. 3
    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles 由 Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope

    出版 2013
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    Artigo
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  4. 4
    Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

    Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery 由 Hyukjin Lee, Abigail K. R. Lytton‐Jean, Yi Chen, Kevin T. Love, Angela I. Park, Emmanouil D. Karagiannis, Alfica Sehgal, William Querbes, Christopher Zurenko, Muthusamy Jayaraman, Chang G. Peng, Klaus Charissé, Anna Borodovsky, Muthiah Manoharan, Jessica Donahoe, Jessica Truelove, Matthias Nahrendorf, Róbert Langer, Daniel G. Anderson

    出版 2012
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  5. 5
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** 由 Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    出版 2012
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  6. 6
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** 由 Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    出版 2012
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    Artigo
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  7. 7
    Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates

    Investigating the pharmacodynamic durability of GalNAc–siRNA conjugates 由 Christopher R. Brown, Swati Gupta, June Qin, Timothy Racie, He Guo, Scott Lentini, Ryan J. Malone, Mikyung Yu, Shigeo Matsuda, Svetlana Shulga‐Morskaya, Anil V. Nair, Christopher S. Theile, Karyn Schmidt, Azar Shahraz, Varun Goel, Rubina Parmar, Ivan Zlatev, Mark K. Schlegel, Jayaprakash K. Nair, Muthusamy Jayaraman, Muthiah Manoharan, Dennis Brown, Martin A. Maier, Vasant Jadhav

    出版 2020
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    Artigo
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  8. 8
    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms 由 Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier

    出版 2010
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    Artigo
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  9. 9
    Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics 由 Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K. Tam, Steven M. Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Kandasamy Pachamuthu, David Butler, Kallanthottathil G. Rajeev, Bo Pang, Klaus Charissé, Kevin Fitzgerald, Barbara L. Mui, Xinyao Du, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope, Muthiah Manoharan, Akin Akinc

    出版 2013
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  10. 10
    Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells

    Systemic RNAi-mediated Gene Silencing in Nonhuman Primate and Rodent Myeloid Cells 由 Tatiana I. Novobrantseva, Anna Borodovsky, Jamie Wong, Boris Klebanov, Mohammad Zafari, Kristina Yucius, William Querbes, Pei Ge, Vera M. Ruda, Stuart Milstein, Lauren Speciner, Rick Duncan, Scott Barros, Genc Basha, Pieter R. Cullis, Akin Akinc, Jessica Donahoe, K. N. Jayaprakash, Muthusamy Jayaraman, Roman L. Bogorad, Kevin T. Love, Katie Whitehead, Chris Levins, Muthiah Manoharan, Filip K. Świrski, Ralph Weissleder, R.M. Langer, Daniel G. Anderson, Antonin de Fougerolles, Matthias Nahrendorf, Victor Koteliansky

    出版 2012
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  11. 11
    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

    A combinatorial library of lipid-like materials for delivery of RNAi therapeutics 由 Akin Akinc, Andreas Zumbuehl, Michael S. Goldberg, Elizaveta S. Leshchiner, Valentina Busini, Naushad Hossain, Sergio Bacallado, David N. Nguyen, Jason Fuller, Rene Alvarez, Anna Borodovsky, Todd Borland, Rainer Constien, Antonin de Fougerolles, J. Robert Dorkin, K. N. Jayaprakash, Muthusamy Jayaraman, Matthias John, Victor Koteliansky, Muthiah Manoharan, Lubomir V. Nechev, June Qin, Timothy Racie, Denitza Raitcheva, Kallanthottathil G. Rajeev, Dinah W.Y. Sah, Jürgen Soutschek, Ivanka Toudjarska, Hans‐Peter Vornlocher, Tracy Zimmermann, Róbert Langer, Daniel G. Anderson

    出版 2008
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  12. 12
    Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

    Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates 由 Maria Frank-Kamenetsky, Aldo Grefhorst, Norma N. Anderson, Timothy Racie, Birgit Bramlage, Akin Akinc, David Butler, Klaus Charissé, Robert Dorkin, Yupeng Fan, Christina Gamba‐Vitalo, Philipp Hadwiger, Muthusamy Jayaraman, Matthias John, K. N. Jayaprakash, Martin A. Maier, Lubomir V. Nechev, Kallanthottathil G. Rajeev, Timothy Read, Ingo Röhl, Jürgen Soutschek, Pamela Tan, Jamie Wong, Gang Wang, Tracy Zimmermann, Antonin de Fougerolles, Hans-Peter Vornlocher, Róbert Langer, Daniel G. Anderson, Muthiah Manoharan, Victor Koteliansky, Jay D. Horton, Kevin Fitzgerald

    出版 2008
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  13. 13
    The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <i>N</i>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human

    The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of <i>N</i>-Acetylgalactosamine–Conjugated Small Interfering RNA Are Highly Predictable and Build Confide... 由 Robin McDougall, Diane Ramsden, Sagar Agarwal, Saket Agarwal, Krishna Aluri, Michael Arciprete, Christopher R. Brown, Elena Castellanos-Rizaldos, Klaus Charissé, Saeho Chong, Joseph A. Cichocki, Kevin Fitzgerald, Varun Goel, Yongli Gu, Dale C. Guenther, Bahru Habtemariam, Vasant Jadhav, Maja M. Janas, Muthusamy Jayaraman, Jeffrey C. Kurz, Jing Li, Ju Liu, Xiumin Liu, Steven Liou, Chris Maclauchlin, Martin A. Maier, Muthiah Manoharan, Jayaprakash K. Nair, Gabriel J. Robbie, Karyn Schmidt, Pete Smith, Christopher S. Theile, Akshay Vaishnaw, Scott Waldron, Yuanxin Xu, Xuemei Zhang, Ivan Zlatev, Jing‐Tao Wu

    出版 2021
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    Revisão
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