检索结果 - Muthiah Manoharan

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  1. 1
    Chemistry, structure and function of approved oligonucleotide therapeutics

    Chemistry, structure and function of approved oligonucleotide therapeutics 由 Martin Egli, Muthiah Manoharan

    出版 2023
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  2. 2
    Acyclic (<i>S</i>)-glycol nucleic acid (<i>S</i>-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency

    Acyclic (<i>S</i>)-glycol nucleic acid (<i>S</i>-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency 由 Martin Egli, Mark K. Schlegel, Muthiah Manoharan

    出版 2023
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  3. 3
    Challenges and Opportunities for Nucleic Acid Therapeutics

    Challenges and Opportunities for Nucleic Acid Therapeutics 由 David R. Corey, Masad J. Damha, Muthiah Manoharan

    出版 2021
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  4. 4
    RNAi therapeutics: a potential new class of pharmaceutical drugs

    RNAi therapeutics: a potential new class of pharmaceutical drugs 由 David Bumcrot, Muthiah Manoharan, Victor Koteliansky, Dinah W.Y. Sah

    出版 2006
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  5. 5
    MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6

    MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6 由 Jan Krützfeldt, Nora Rösch, Jean Hausser, Muthiah Manoharan, Mihaela Zavolan, Markus Stoffel

    出版 2011
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  6. 6
    2′‐Fluoro RNA Shows Increased Watson–Crick H‐Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data

    2′‐Fluoro RNA Shows Increased Watson–Crick H‐Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data 由 Amritraj Patra, Michael Paolillo, Klaus Charissé, Muthiah Manoharan, Eriks Rozners, Martin Egli

    出版 2012
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  7. 7
    Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues

    Efficient Solid-Phase Chemical Synthesis of 5′-Triphosphates of DNA, RNA, and their Analogues 由 Ivan Zlatev, Thomas Lavergne, Françoise Debart, Jean‐Jacques Vasseur, Muthiah Manoharan, F. Morvan

    出版 2010
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  8. 8
    Activation of LDL Receptor Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter

    Activation of LDL Receptor Expression by Small RNAs Complementary to a Noncoding Transcript that Overlaps the LDLR Promoter 由 Masayuki Matsui, Fuminori Sakurai, Sayda M. Elbashir, Donald J. Foster, Muthiah Manoharan, David R. Corey

    出版 2010
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  9. 9
    Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

    Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes 由 Erich Koller, Thomas M. Vincent, Alfred E. Chappell, Soma De, Muthiah Manoharan, C. Frank Bennett

    出版 2011
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  10. 10
    Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells

    Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells 由 Purva Khare, Kandarp M. Dave, Yashika S. Kamte, Muthiah Manoharan, Lauren A. O’Donnell, Devika S. Manickam

    出版 2021
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  11. 11
    Influenza A virus-generated small RNAs regulate the switch from transcription to replication

    Influenza A virus-generated small RNAs regulate the switch from transcription to replication 由 Jasmine T. Perez, Andrew Varble, Ravi Sachidanandam, Ivan Zlatev, Muthiah Manoharan, Adolfo García‐Sastre, Benjamin R. tenOever

    出版 2010
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  12. 12
    Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA

    Unexpected origins of the enhanced pairing affinity of 2′-fluoro-modified RNA 由 Pradeep S. Pallan, Emily M. Greene, Paul Andrei Jicman, Rajendra K. Pandey, Muthiah Manoharan, Eriks Rozners, Martin Egli

    出版 2010
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  13. 13
    Specificity, duplex degradation and subcellular localization of antagomirs

    Specificity, duplex degradation and subcellular localization of antagomirs 由 Jan Krützfeldt, Satoru Kuwajima, Ravi Braich, Kallanthottathil G. Rajeev, John Pena, Thomas Tuschl, Muthiah Manoharan, Markus Stoffel

    出版 2007
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  14. 14
    siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2

    siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2 由 Elad Elkayam, Rubina Parmar, Christopher R. Brown, Jennifer L. S. Willoughby, Christopher S. Theile, Muthiah Manoharan, Leemor Joshua‐Tor

    出版 2016
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  15. 15
    Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

    Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown 由 Anders Wittrup, Angela Ai, Xing Liu, Péter Hamar, Radiana Trifonova, Klaus Charissé, Muthiah Manoharan, Tomas Kirchhausen, Judy Lieberman

    出版 2015
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  16. 16
    Intravesical Delivery of Small Activating RNA Formulated into Lipid Nanoparticles Inhibits Orthotopic Bladder Tumor Growth

    Intravesical Delivery of Small Activating RNA Formulated into Lipid Nanoparticles Inhibits Orthotopic Bladder Tumor Growth 由 Moo Rim Kang, Glen Yang, Robert F. Place, Klaus Charissé, Hila Epstein-Barash, Muthiah Manoharan, Long‐Cheng Li

    出版 2012
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  17. 17
    Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA

    Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA 由 Md. Rowshon Alam, Xin Ming, Michael H. Fisher, Jeremy G. Lackey, Kallanthottathil G. Rajeev, Muthiah Manoharan, R. L. Juliano

    出版 2011
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  18. 18
    A Small-RNA Enhancer of Viral Polymerase Activity

    A Small-RNA Enhancer of Viral Polymerase Activity 由 Jasmine T. Perez, Ivan Zlatev, Shilpa Aggarwal, Sai Lakshmi Subramanian, Ravi Sachidanandam, Baek Kim, Muthiah Manoharan, Benjamin R. tenOever

    出版 2012
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  19. 19
    Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

    Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs 由 Peter Sazani, Shin-Hong Kang, Martin A. Maier, Changfu Wei, Jennifer Dillman, James E. Summerton, Muthiah Manoharan, Ryszard Kole

    出版 2001
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  20. 20
    Promoter RNA links transcriptional regulation of inflammatory pathway genes

    Promoter RNA links transcriptional regulation of inflammatory pathway genes 由 Masayuki Matsui, Yongjun Chu, Huiying Zhang, Keith T. Gagnon, Sarfraz Shaikh, Satya Kuchimanchi, Muthiah Manoharan, David R. Corey, Bethany A. Janowski

    出版 2013
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