Resultados da busca - Murphy, Leon

A Network of Immediate Early Gene Products Propagates Subtle Differences in Mitogen-Activated Protein Kinase Signal Amplitude and Duration por Murphy, Leon O., MacKeigan, Jeffrey P., Blenis, John

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Total Lipopolysaccharide from the Human Gut Microbiome Silences Toll-Like Receptor Signaling por d’Hennezel, Eva, Abubucker, Sahar, Murphy, Leon O., Cullen, Thomas W.

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Characterization of Regulatory Events Associated with Membrane Targeting of p90 Ribosomal S6 Kinase 1 por Richards, Stephanie A., Dreisbach, Valley C., Murphy, Leon O., Blenis, John

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Graded Mitogen-Activated Protein Kinase Activity Precedes Switch-Like c-Fos Induction in Mammalian Cells por MacKeigan, Jeffrey P., Murphy, Leon O., Dimitri, Christopher A., Blenis, John

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Relieving Autophagy and 4EBP1 from Rapamycin Resistance por Nyfeler, Beat, Bergman, Philip, Triantafellow, Ellen, Wilson, Christopher J., Zhu, Yanyi, Radetich, Branko, Finan, Peter M., Klionsky, Daniel J., Murphy, Leon O.

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1 por Dibble, Christian C., Elis, Winfried, Menon, Suchithra, Qin, Wei, Klekota, Justin, Asara, John M., Finan, Peter M., Kwiatkowski, David J., Murphy, Leon O., Manning, Brendan D.

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Atg4b-Dependent Autophagic Flux Alleviates Huntington’s Disease Progression por Proenca, Catia C., Stoehr, Natacha, Bernhard, Mario, Seger, Shanon, Genoud, Christel, Roscic, Ana, Paganetti, Paolo, Liu, Shanming, Murphy, Leon O., Kuhn, Rainer, Bouwmeester, Tewis, Galimberti, Ivan

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Autophagy-independent lysosomal targeting regulated by ULK1/2-FIP200 and ATG9 por Goodwin, Jonathan M., Dowdle, William E., DeJesus, Rowena, Wang, Zuncai, Bergman, Philip, Kobylarz, Marek, Lindeman, Alicia, Xavier, Ramnik, McAllister, Gregory, Nyfeler, Beat, Hoffman, Gregory, Murphy, Leon O.

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RAD001 Enhances the Potency of BEZ235 to Inhibit mTOR Signaling and Tumor Growth por Nyfeler, Beat, Chen, Yan, Li, Xiaoyan, Pinzon-Ortiz, Maria, Wang, Zuncai, Reddy, Anupama, Pradhan, Elina, Das, Rita, Lehár, Joseph, Schlegel, Robert, Finan, Peter M., Cao, Z. Alexander, Murphy, Leon O., Huang, Alan

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MK-STYX, a Catalytically Inactive Phosphatase Regulating Mitochondrially Dependent Apoptosis por Niemi, Natalie M., Lanning, Nathan J., Klomp, Jeff A., Tait, Stephen W., Xu, Yong, Dykema, Karl J., Murphy, Leon O., Gaither, L. Alex, Xu, H. Eric, Furge, Kyle A., Green, Douglas R., MacKeigan, Jeffrey P.

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Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice por Fetalvero, Kristina M., Yu, Yenyen, Goetschkes, Margaret, Liang, Guiqing, Valdez, Reginald A., Gould, Ty, Triantafellow, Ellen, Bergling, Sebastian, Loureiro, Joseph, Eash, John, Lin, Victor, Porter, Jeffrey A., Finan, Peter M., Walsh, Kenneth, Yang, Yi, Mao, Xiaohong, Murphy, Leon O.

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1 por Düvel, Katrin, Yecies, Jessica L., Menon, Suchithra, Raman, Pichai, Lipovsky, Alex I., Souza, Amanda L., Triantafellow, Ellen, Ma, Qicheng, Gorski, Regina, Cleaver, Stephen, Heiden, Matthew G. Vander, MacKeigan, Jeffrey P., Finan, Peter M., Clish, Clary B., Murphy, Leon O., Manning, Brendan D.

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy por Nicklin, Paul, Bergman, Philip, Zhang, Bailin, Triantafellow, Ellen, Wang, Henry, Nyfeler, Beat, Yang, Haidi, Hild, Marc, Kung, Charles, Wilson, Christopher, Myer, Vic E., MacKeigan, Jeffrey P., Porter, Jeffrey A., Wang, Y. Karen, Cantley, Lewis C., Finan, Peter M., Murphy, Leon O.

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TMEM41B is a novel regulator of autophagy and lipid mobilization por Moretti, Francesca, Bergman, Phil, Dodgson, Stacie, Marcellin, David, Claerr, Isabelle, Goodwin, Jonathan M, DeJesus, Rowena, Kang, Zhao, Antczak, Christophe, Begue, Damien, Bonenfant, Debora, Graff, Alexandra, Genoud, Christel, Reece‐Hoyes, John S, Russ, Carsten, Yang, Zinger, Hoffman, Gregory R, Mueller, Matthias, Murphy, Leon O, Xavier, Ramnik J, Nyfeler, Beat

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Targeting quiescent leukemic stem cells using second generation autophagy inhibitors por Baquero, Pablo, Dawson, Amy, Mukhopadhyay, Arunima, Kuntz, Elodie M., Mitchell, Rebecca, Olivares, Orianne, Ianniciello, Angela, Scott, Mary T., Dunn, Karen, Nicastri, Michael C., Winkler, Jeffrey D., Michie, Alison M., Ryan, Kevin M., Halsey, Christina, Gottlieb, Eyal, Keaney, Erin P., Murphy, Leon O., Amaravadi, Ravi K., Holyoake, Tessa L., Helgason, G. Vignir

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An iron-dependent metabolic vulnerability underlies VPS34-dependence in RKO cancer cells por Kobylarz, Marek J., Goodwin, Jonathan M., Kang, Zhao B., Annand, John W., Hevi, Sarah, O’Mahony, Ellen, McAllister, Gregory, Reece-Hoyes, John, Wang, Qiong, Alford, John, Russ, Carsten, Lindeman, Alicia, Beibel, Martin, Roma, Guglielmo, Carbone, Walter, Knehr, Judith, Loureiro, Joseph, Antczak, Christophe, Wiederschain, Dmitri, Murphy, Leon O., Menon, Suchithra, Nyfeler, Beat

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Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62 por DeJesus, Rowena, Moretti, Francesca, McAllister, Gregory, Wang, Zuncai, Bergman, Phil, Liu, Shanming, Frias, Elizabeth, Alford, John, Reece-Hoyes, John S, Lindeman, Alicia, Kelliher, Jennifer, Russ, Carsten, Knehr, Judith, Carbone, Walter, Beibel, Martin, Roma, Guglielmo, Ng, Aylwin, Tallarico, John A, Porter, Jeffery A, Xavier, Ramnik J, Mickanin, Craig, Murphy, Leon O, Hoffman, Gregory R, Nyfeler, Beat

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Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation por Wlodarska, Marta, Luo, Chengwei, Kolde, Raivo, d’Hennezel, Eva, Annand, John W., Heim, Cortney E., Krastel, Philipp, Schmitt, Esther K., Omar, Abdifatah S., Creasey, Elizabeth A., Garner, Ashley L., Mohammadi, Sina, O’Connell, Daniel J., Abubucker, Sahar, Arthur, Timothy D., Franzosa, Eric A., Huttenhower, Curtis, Murphy, Leon O., Haiser, Henry J., Vlamakis, Hera, Porter, Jeffrey A., Xavier, Ramnik J.

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PIKfyve, a class III PI-kinase, is the target of the small molecular IL12/23 inhibitor apilimod and a new player in toll-like receptor signaling por Cai, Xinming, Xu, Yongyao, Cheung, Atwood K., Tomlinson, Ronald C., Alcázar-Román, Abel, Murphy, Leon, Billich, Andreas, Zhang, Bailin, Feng, Yan, Klumpp, Martin, Rondeau, Jean-Michel, Fazal, Aleem N., Wilson, Christopher J., Myer, Vic, Joberty, Gerard, Bouwmeester, Tewis, Labow, Mark A., Finan, Peter M., Porter, Jeffrey A., Ploegh, Hidde L., Baird, Daniel, De Camilli, Pietro, Tallarico, John A., Huang, Qian

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Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism por Bilanges, Benoit, Alliouachene, Samira, Pearce, Wayne, Morelli, Daniele, Szabadkai, Gyorgy, Chung, Yuen-Li, Chicanne, Gaëtan, Valet, Colin, Hill, Julia M., Voshol, Peter J., Collinson, Lucy, Peddie, Christopher, Ali, Khaled, Ghazaly, Essam, Rajeeve, Vinothini, Trichas, Georgios, Srinivas, Shankar, Chaussade, Claire, Salamon, Rachel S., Backer, Jonathan M., Scudamore, Cheryl L., Whitehead, Maria A., Keaney, Erin P., Murphy, Leon O., Semple, Robert K., Payrastre, Bernard, Tooze, Sharon A., Vanhaesebroeck, Bart

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