检索结果 - Moiani, Davide

Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair 由 Limbo, Oliver, Moiani, Davide, Kertokalio, Aryandi, Wyman, Claire, Tainer, John A., Russell, Paul

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Targeting Allostery with Avatars to Design Inhibitors Assessed by Cell Activity: Dissecting MRE11 Endo- and Exonuclease Activities 由 Moiani, Davide, Ronato, Daryl A., Brosey, Chris A., Arvai, Andrew S., Syed, Aleem, Masson, Jean-Yves, Petric, Elena, Tainer, John A.

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Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response 由 Wilson, David M., Deacon, Ashley M., Duncton, Matthew A.J., Pellicena, Patricia, Georgiadis, Millie M., Yeh, Andrew P., Arvai, Andrew S., Moiani, Davide, Tainer, John A., Das, Debanu

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MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA 由 Lee, Ka Cheong, Padget, Kay, Curtis, Hannah, Cowell, Ian G., Moiani, Davide, Sondka, Zbyslaw, Morris, Nicholas J., Jackson, Graham H., Cockell, Simon J., Tainer, John A., Austin, Caroline A.

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An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 由 Moiani, Davide, Link, Todd M., Brosey, Chris A., Katsonis, Panagiotis, Lichtarge, Olivier, Kim, Youngchang, Joachimiak, Andrzej, Ma, Zhijun, Kim, In-Kwon, Ahmed, Zamal, Jones, Darin E., Tsutakawa, Susan E., Tainer, John A.

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Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair 由 Williams, R. Scott, Moncalian, Gabriel, Williams, Jessica S., Yamada, Yoshiki, Limbo, Oliver, Shin, David S., Groocock, Lynda M., Cahill, Dana, Hitomi, Chiharu, Guenther, Grant, Moiani, Davide, Carney, James P., Russell, Paul, Tainer, John A.

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GRB2 enforces homology-directed repair initiation by MRE11 由 Ye, Zu, Xu, Shengfeng, Shi, Yin, Bacolla, Albino, Syed, Aleem, Moiani, Davide, Tsai, Chi-Lin, Shen, Qiang, Peng, Guang, Leonard, Paul G., Jones, Darin E., Wang, Bin, Tainer, John A., Ahmed, Zamal

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RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response 由 Groocock, Lynda M, Nie, Minghua, Prudden, John, Moiani, Davide, Wang, Tao, Cheltsov, Anton, Rambo, Robert P, Arvai, Andrew S, Hitomi, Chiharu, Tainer, John A, Luger, Karolin, Perry, J Jefferson P, Lazzerini-Denchi, Eros, Boddy, Michael N

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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors 由 Brosey, Chris A., Houl, Jerry H., Katsonis, Panagiotis, Balapiti-Modarage, Lakshitha P.F., Bommagani, Shobanbabu, Arvai, Andy, Moiani, Davide, Bacolla, Albino, Link, Todd, Warden, Leslie S., Lichtarge, Olivier, Jones, Darin E., Ahmed, Zamal, Tainer, John A.

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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation 由 Nguyen, My T., Moiani, Davide, Ahmed, Zamal, Arvai, Andrew S., Namjoshi, Sarita, Shin, Dave S., Fedorov, Yuriy, Selvik, Edward J., Jones, Darin E., Pink, John, Yan, Yan, Laverty, Daniel J., Nagel, Zachary D., Tainer, John A., Gerson, Stanton L.

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DNA Double Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities 由 Shibata, Atsushi, Moiani, Davide, Arvai, Andrew S., Perry, J. Jefferson P., Harding, Shane M., Genois, Marie-Michelle, Maity, Ranjan, van Rossum-Fikkert, Sari, Kertokalio, Aryandi, Romoli, Filippo, Ismail, Amani, Ismalaj, Ermal, Petricci, Elena, Matthew, J Neale, Bristow, Robert G, Masson, Jean-Yves, Wyman, Claire, Jeggo, Penny, Tainer, John A.

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Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1 由 Yuan, Xiangliang, Duan, Yimin, Xiao, Yi, Sun, Kai, Qi, Yutao, Zhang, Yuan, Ahmed, Zamal, Moiani, Davide, Yao, Jun, Li, Hongzhong, Zhang, Lin, Yuzhalin, Arseniy E., Li, Ping, Zhang, Chenyu, Badu-Nkansah, Akosua, Saito, Yohei, Liu, Xianghua, Kuo, Wen-Ling, Ying, Haoqiang, Sun, Shao-Cong, Chang, Jenny C., Tainer, John A., Yu, Dihua

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Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death 由 Houl, Jerry H., Ye, Zu, Brosey, Chris A., Balapiti-Modarage, Lakshitha P. F., Namjoshi, Sarita, Bacolla, Albino, Laverty, Daniel, Walker, Brian L., Pourfarjam, Yasin, Warden, Leslie S., Babu Chinnam, Naga, Moiani, Davide, Stegeman, Roderick A., Chen, Mei-Kuang, Hung, Mien-Chie, Nagel, Zachary D., Ellenberger, Tom, Kim, In-Kwon, Jones, Darin E., Ahmed, Zamal, Tainer, John A.

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Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that may Discriminate Substrates During DNA Repair 由 Das, Debanu, Moiani, Davide, Axelrod, Herbert L., Miller, Mitchell D., McMullan, Daniel, Jin, Kevin K., Abdubek, Polat, Astakhova, Tamara, Burra, Prasad, Carlton, Dennis, Chiu, Hsiu-Ju, Clayton, Thomas, Deller, Marc C., Duan, Lian, Ernst, Dustin, Feuerhelm, Julie, Grant, Joanna C., Grzechnik, Anna, Grzechnik, Slawomir K., Han, Gye Won, Jaroszewski, Lukasz, Klock, Heath E., Knuth, Mark W., Kozbial, Piotr, Krishna, S. Sri, Kumar, Abhinav, Marciano, David, Morse, Andrew T., Nigoghossian, Edward, Okach, Linda, Paulsen, Jessica, Reyes, Ron, Rife, Christopher L., Sefcovic, Natasha, Tien, Henry J., Trame, Christine B., van den Bedem, Henry, Weekes, Dana, Xu, Qingping, Hodgson, Keith O., Wooley, John, Elsliger, Marc-André, Deacon, Ashley M., Godzik, Adam, Lesley, Scott A., Tainer, John A., Wilson, Ian A.

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