Resultats de la cerca - Mohamad Hamieh

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  1. 1
    Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating

    Programming CAR T Cell Tumor Recognition: Tuned Antigen Sensing and Logic Gating per Mohamad Hamieh, Jorge Mansilla‐Soto, Isabelle Rivière, Michel Sadelain

    Publicat 2023
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  2. 2
    The pharmacology of second-generation chimeric antigen receptors

    The pharmacology of second-generation chimeric antigen receptors per Sjoukje J. C. van der Stegen, Mohamad Hamieh, Michel Sadelain

    Publicat 2015
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  3. 3
    CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade

    CAR T cell–induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade per Theodoros Giavridis, Sjoukje J. C. van der Stegen, Justin Eyquem, Mohamad Hamieh, Alessandra Piersigilli, Michel Sadelain

    Publicat 2018
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  4. 4
    Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools

    Exonic Splicing Mutations Are More Prevalent than Currently Estimated and Can Be Predicted by Using In Silico Tools per Omar Soukarieh, Pascaline Gaildrat, Mohamad Hamieh, Aurélie Drouet, Stéphanie Baert‐Desurmont, Thierry Frébourg, Mario Tosi, Alexandra Martins

    Publicat 2016
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  5. 5
    Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape

    Low-Dose Radiation Conditioning Enables CAR T Cells to Mitigate Antigen Escape per Carl J. DeSelm, M. Lia Palomba, Joachim Yahalom, Mohamad Hamieh, Justin Eyquem, Vinagolu K. Rajasekhar, Michel Sadelain

    Publicat 2018
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  6. 6
    Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML

    Integrating Proteomics and Transcriptomics for Systematic Combinatorial Chimeric Antigen Receptor Therapy of AML per Fabiana Perna, Samuel H. Berman, Rajesh Soni, Jorge Mansilla‐Soto, Justin Eyquem, Mohamad Hamieh, Ronald C. Hendrickson, Cameron Brennan, Michel Sadelain

    Publicat 2017
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  7. 7
    Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

    Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency per Judith Feucht, Jie Sun, Justin Eyquem, Yu-Jui Ho, Zeguo Zhao, Josef Leibold, Anton Dobrin, Annalisa Cabriolu, Mohamad Hamieh, Michel Sadelain

    Publicat 2018
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  8. 8
    Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

    Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection per Justin Eyquem, Jorge Mansilla‐Soto, Theodoros Giavridis, Sjoukje J. C. van der Stegen, Mohamad Hamieh, Kristen Cunanan, Ashlesha Odak, Mithat Gönen, Michel Sadelain

    Publicat 2017
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  9. 9
    Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies

    Synthetic dual co-stimulation increases the potency of HIT and TCR-targeted cell therapies per Anton Dobrin, Pieter L. Lindenbergh, Yuzhe Shi, Karlo Perica, Hongyao Xie, Nayan Jain, Andrew Chow, Jedd D. Wolchok, Taha Merghoub, Michel Sadelain, Mohamad Hamieh

    Publicat 2024
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  10. 10
    T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blasts

    T-cell responses against CD19+ pediatric acute lymphoblastic leukemia mediated by bispecific T-cell engager (BiTE) are regulated contrarily by PD-L1 and CD80/CD86 on leukemic blast... per Judith Feucht, Simone Kayser, David Gorodezki, Mohamad Hamieh, Michaela Döring, Franziska Blaeschke, Patrick Schlegel, Hans Bösmüller, Leticia Quintanilla-Martı́nez, Martin Ebinger, Peter Lang, Rupert Handgretinger, Tobias Feuchtinger

    Publicat 2016
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  11. 11
    Immunogenicity of CAR T cells in cancer therapy

    Immunogenicity of CAR T cells in cancer therapy per Dimitrios L. Wagner, Enrico Fritsche, Michael A. Pulsipher, Nabil Ahmed, Mohamad Hamieh, Meenakshi Hegde, Marco Ruella, Barbara Savoldo, Nirali N. Shah, Cameron J. Turtle, Alan S. Wayne, Mohamed Abou‐El‐Enein

    Publicat 2021
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  12. 12
    CD19 CAR antigen engagement mechanisms and affinity tuning

    CD19 CAR antigen engagement mechanisms and affinity tuning per Changhao He, Jorge Mansilla‐Soto, Nandish Khanra, Mohamad Hamieh, Victor Bustos, Alice J. Paquette, Andreina Garcia Angus, Derek M. Shore, William J. Rice, George Khelashvili, Michel Sadelain, Joel R. Meyerson

    Publicat 2023
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  13. 13
    CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

    CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape per Mohamad Hamieh, Anton Dobrin, Annalisa Cabriolu, Sjoukje J. C. van der Stegen, Theodoros Giavridis, Jorge Mansilla‐Soto, Justin Eyquem, Zeguo Zhao, Benjamin M. Whitlock, Matthew M. Miele, Zhuoning Li, Kristen Cunanan, Morgan Huse, Ronald C. Hendrickson, Xiuyan Wang, Isabelle Rivière, Michel Sadelain

    Publicat 2019
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  14. 14
    Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells

    Generation of T-cell-receptor-negative CD8αβ-positive CAR T cells from T-cell-derived induced pluripotent stem cells per Sjoukje J. C. van der Stegen, Pieter L. Lindenbergh, Roseanna M. Petrovic, Hongyao Xie, Mame P. Diop, Vera Alexeeva, Yuzhe Shi, Jorge Mansilla‐Soto, Mohamad Hamieh, Justin Eyquem, Annalisa Cabriolu, Xiuyan Wang, Ramzey Abujarour, Tom T. Lee, Raedun Clarke, Bahram Valamehr, Maria Themeli, Isabelle Rivière, Michel Sadelain

    Publicat 2022
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  15. 15
    Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy

    Correlation between Density of CD8+ T-cell Infiltrate in Microsatellite Unstable Colorectal Cancers and Frameshift Mutations: A Rationale for Personalized Immunotherapy per Pauline Maby, David Tougeron, Mohamad Hamieh, Bernhard Mlecnik, Hafid Kora, Gabriela Bindea, Helen K. Angell, Tessa Fredriksen, Nicolas Elie, Émilie Fauquembergue, Aurélie Drouet, Jérôme Leprince, Jacques Bénichou, Jacques Mauillon, Florence Le Pessot, Richard Sesboüé, Jean‐Jacques Tuech, Jean‐Christophe Sabourin, Michel Pierre, Thierry Frébourg, Jérôme Galon, Jean‐Baptiste Latouche

    Publicat 2015
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  16. 16
    HLA-independent T cell receptors for targeting tumors with low antigen density

    HLA-independent T cell receptors for targeting tumors with low antigen density per Jorge Mansilla‐Soto, Justin Eyquem, Sascha Haubner, Mohamad Hamieh, Judith Feucht, Noémie Paillon, Andrés E. Zucchetti, Zhuoning Li, Maria Sjöstrand, Pieter L. Lindenbergh, Michelle Sætersmoen, Anton Dobrin, Mathieu Maurin, Archana Iyer, Andreina Garcia Angus, Matthew M. Miele, Zeguo Zhao, Theodoros Giavridis, Sjoukje J. C. van der Stegen, Fella Tamzalit, Isabelle Rivière, Morgan Huse, Ronald C. Hendrickson, Claire Hivroz, Michel Sadelain

    Publicat 2022
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  17. 17
    Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability

    Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability per Bernhard Mlecnik, Gabriela Bindea, Helen K. Angell, Pauline Maby, Mihaela Angelova, David Tougeron, S. Church, Lucie Lafontaine, M. Fischer, Tessa Fredriksen, Maristella Sasso, Amélie M. Bilocq, Amos Kirilovsky, Anna C. Obenauf, Mohamad Hamieh, Anne Berger, Patrick Bruneval, Jean‐Jacques Tuech, Jean‐Christophe Sabourin, Florence Le Pessot, Jacques Mauillon, Arash Rafii, Pierre Laurent‐Puig, Michael R. Speicher, Zlatko Trajanoski, Michel Pierre, Richard Sesboüé, Thierry Frébourg, Franck Pagès, Viia Valge-Archer, Jean‐Baptiste Latouche, Jérôme Galon

    Publicat 2016
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