Search Results - Michael R. Hughes

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  1. 1
    The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apoptosis

    The Src Homology 2 (SH2) Domain of SH2-containing Inositol Phosphatase (SHIP) Is Essential for Tyrosine Phosphorylation of SHIP, Its Association with Shc, and Its Induction of Apop... by Ling Liu, Jacqueline E. Damen, Michael R. Hughes, Ivan Babić, Frank R. Jirik, Gerald Krystal

    Published 1997
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  2. 2
    Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation

    Protein Kinase C-δ Is a Negative Regulator of Antigen-Induced Mast Cell Degranulation by Michael Leitges, Kerstin Gimborn, Winfried Elis, Janet Kalesnikoff, Michael R. Hughes, Gerald Krystal, Michael Huber

    Published 2002
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  3. 3
    SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity

    SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity by Janet Kalesnikoff, Nicole Baur, Michael Leitges, Michael R. Hughes, Jacqueline E. Damen, Michael Huber, Gerald Krystal

    Published 2002
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  4. 4
    Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma

    Butyrate Shapes Immune Cell Fate and Function in Allergic Asthma by William Yip, Michael R. Hughes, Yicong Li, Alissa Cait, Martin Hirst, William W. Mohn, Kelly M. McNagny

    Published 2021
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  5. 5
    The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta

    The Molecular Basis of Vascular Lumen Formation in the Developing Mouse Aorta by Boris Strilić, Tomáš Kučera, Jan Eglinger, Michael R. Hughes, Kelly M. McNagny, Sachiko Tsukita, Elisabetta Dejana, Napoleone Ferrara, Eckhard Lammert

    Published 2009
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  6. 6
    The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease

    The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn’s disease by Bernard C. Lo, Matthew J. Gold, Michael R. Hughes, Frann Antignano, Yanet Valdez, Colby Zaph, Kenneth W. Harder, Kelly M. McNagny

    Published 2016
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  7. 7
    Type-2 innate signals are dispensable for skeletal muscle regeneration and pathology linked to Duchenne muscular dystrophy

    Type-2 innate signals are dispensable for skeletal muscle regeneration and pathology linked to Duchenne muscular dystrophy by Melina Messing, Marine Théret, Michael R. Hughes, Jun Wu, Omar Husain Syed, Fang Fang Li, Yicong Li, Fábio Rossi, Kelly M. McNagny

    Published 2025
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  8. 8
    Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473

    Phosphatidylinositol (3,4,5)P3 Is Essential but Not Sufficient for Protein Kinase B (PKB) Activation; Phosphatidylinositol (3,4)P2 Is Required for PKB Phosphorylation at Ser-473 by Michael P. Scheid, Michael Huber, Jacqueline E. Damen, Michael R. Hughes, Veronica H. Kang, Paul O. Neilsen, Glenn D. Prestwich, Gerald Krystal, Vincent Duronio

    Published 2002
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  9. 9
    DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis

    DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis by Ingrid Elisia, Hisae Nakamura, Vivian Lam, Elyse Hofs, Rachel A. Cederberg, Jessica Cait, Michael R. Hughes, Leora Lee, William Jia, Hans Adomat, Emma S. Tomlinson Guns, Kelly M. McNagny, Ismael Samudio, Gerald Krystal

    Published 2016
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  10. 10
    Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids

    Microbiome-driven allergic lung inflammation is ameliorated by short-chain fatty acids by Alissa Cait, Michael R. Hughes, Frann Antignano, Jessica Cait, Pedro A. Dimitriu, Kendra Maas, Lisa A. Reynolds, L Hacker, Julia Mohr, B. Brett Finlay, Colby Zaph, Kelly M. McNagny, William W. Mohn

    Published 2017
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  11. 11
    SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens

    SIGIRR, a Negative Regulator of TLR/IL-1R Signalling Promotes Microbiota Dependent Resistance to Colonization by Enteric Bacterial Pathogens by Ho Pan Sham, Emily Yi Shan Yu, Muhammet F. Gülen, Ganive Bhinder, Martin Ståhl, Justin M. Chan, Lara Brewster, Vijay Morampudi, Deanna L. Gibson, Michael R. Hughes, Kelly M. McNagny, Xiaoxia Li, Bruce A. Vallance

    Published 2013
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  12. 12
    G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program

    G9a regulates group 2 innate lymphoid cell development by repressing the group 3 innate lymphoid cell program by Frann Antignano, Mitchell J.S. Braam, Michael R. Hughes, Alistair Chenery, Kyle Burrows, Matthew J. Gold, Menno J. Oudhoff, David Rattray, Timotheus Y.F. Halim, Alissa Cait, Fumio Takei, Fábio Rossi, Kelly M. McNagny, Colby Zaph

    Published 2016
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  13. 13
    Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice

    Impact of a CXCL12/CXCR4 Antagonist in Bleomycin (BLM) Induced Pulmonary Fibrosis and Carbon Tetrachloride (CCl4) Induced Hepatic Fibrosis in Mice by Leola N. Y. Chow, Petra Schreiner, Betina Y. Y. Ng, Bernard C. Lo, Michael R. Hughes, R. Wilder Scott, Vionarica Gusti, S. Lecour, Eric Simonson, Irina Manisali, Ingrid Barta, Kelly M. McNagny, Jason Crawford, Murray S. Webb, T. Michael Underhill

    Published 2016
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  14. 14
    Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation

    Podocalyxin is required for maintaining blood–brain barrier function during acute inflammation by Jessica Cait, Michael R. Hughes, Matthew R. Zeglinski, Allen W. Chan, Sabrina Osterhof, R. Wilder Scott, Diana Canals Hernaez, Alissa Cait, A. Wayne Vogl, Pascal Bernatchez, T. Michael Underhill, David J. Granville, Timothy H. Murphy, Calvin D. Roskelley, Kelly M. McNagny

    Published 2019
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  15. 15
    Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

    Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy by Kimberly Snyder, Michael R. Hughes, Bradley J. Hedberg, Jill Brandon, Diana Canals Hernaez, Peter Bergqvist, Frederic Cruz, Kelvin Po, Marcia L. Graves, Michelle E. Turvey, Julie S. Nielsen, John A. Wilkins, Shaun R. McColl, John S. Babcook, Calvin D. Roskelley, Kelly M. McNagny

    Published 2015
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  16. 16
    Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development

    Gene-Edited Human Kidney Organoids Reveal Mechanisms of Disease in Podocyte Development by Yong Kyun Kim, Ido Refaeli, Craig R. Brooks, Peifeng Jing, Ramila E. Gulieva, Michael R. Hughes, Nelly M. Cruz, Yannan Liu, Angela J. Churchill, Yuliang Wang, Hongxia Fu, Jeffrey W. Pippin, Lih Y. Lin, Stuart J. Shankland, A. Wayne Vogl, Kelly M. McNagny, Benjamin Freedman

    Published 2017
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  17. 17
    Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation

    Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation by Frann Antignano, Kyle Burrows, Michael R. Hughes, Jonathan M. Han, Ken J. Kron, Nadia M. Penrod, Menno J. Oudhoff, Steven Kai Hao Wang, Hoon‐Ki Min, Matthew J. Gold, Alistair Chenery, Mitchell J.S. Braam, Thomas C. Fung, Fábio Rossi, Kelly M. McNagny, C.H. Arrowsmith, Mathieu Lupien, Megan K. Levings, Colby Zaph

    Published 2014
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  18. 18
    Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids

    Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids by Benjamin Freedman, Craig R. Brooks, Albert Q. Lam, Hongxia Fu, Ryuji Morizane, Vishesh Agrawal, Abdelaziz F. Saad, Michelle K. Li, Michael R. Hughes, Ryan Vander Werff, Derek Peters, Junjie Lu, Anna Baccei, Andrew M. Siedlecki, M. Todd Valerius, Yan V. Sun, Kelly M. McNagny, Theodore I. Steinman, Jing Zhou, Paul H. Lerou, Joseph V. Bonventre

    Published 2015
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