Výsledky vyhledávání - Michael G. Natchus

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  1. 1
    Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19

    Developing a direct acting, orally available antiviral agent in a pandemic: the evolution of molnupiravir as a potential treatment for COVID-19 Autor George R. Painter, Michael G. Natchus, Oren J. Cohen, Wendy Holman, Wendy Painter

    Vydáno 2021
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  2. 2
    Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model

    Quantitative efficacy paradigms of the influenza clinical drug candidate EIDD-2801 in the ferret model Autor Märt Toots, Jeong-Joong Yoon, M. N. Hart, Michael G. Natchus, George R. Painter, Richard K. Plemper

    Vydáno 2019
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  3. 3
    β- <scp>d</scp> - <i>N</i> <sup>4</sup> -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome

    β- <scp>d</scp> - <i>N</i> <sup>4</sup> -Hydroxycytidine Is a Potent Anti-alphavirus Compound That Induces a High Level of Mutations in the Viral Genome Autor Nadya Urakova, Valeriya Kuznetsova, David K. Crossman, Arpine Sokratian, David B. Guthrie, Alexander A. Kolykhalov, Mark A. Lockwood, Michael G. Natchus, Michael R. Crowley, George R. Painter, Elena I. Frolova, Ilya Frolov

    Vydáno 2017
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  4. 4
    Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors

    Moderation of iodoacetate-induced experimental osteoarthritis in rats by matrix metalloproteinase inhibitors Autor Michael J. Janusz, E.B. Hookfin, S.A. Heitmeyer, J. Frederick Woessner, Anthony J. Freemont, Judith A. Hoyland, Kimberly K. Brown, Lily C. Hsieh, Neil G. Almstead, B De, Michael G. Natchus, S. PIKUL, Yetunde O. Taiwo

    Vydáno 2001
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  5. 5
    An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model

    An Orally Available, Small-Molecule Polymerase Inhibitor Shows Efficacy Against a Lethal Morbillivirus Infection in a Large Animal Model Autor Stefanie A. Krumm, Dan Yan, Elise S. Hovingh, Taylor J. Evers, Theresa Enkirch, G. Prabhakar Reddy, Aiming Sun, Manohar Saindane, Richard F. Arrendale, George R. Painter, Dennis C. Liotta, Michael G. Natchus, Veronika von Messling, Richard K. Plemper

    Vydáno 2014
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  6. 6
    4′-Fluorouridine inhibits alphavirus replication and infection <i>in vitro</i> and <i>in vivo</i>

    4′-Fluorouridine inhibits alphavirus replication and infection <i>in vitro</i> and <i>in vivo</i> Autor Peiqi Yin, Nicholas May, Laura Sandra Lello, Atef Fayed, M. Guston Parks, Adam M. Drobish, Sainan Wang, Meghan K. Andrews, Zachary M. Sticher, Alexander A. Kolykhalov, Michael G. Natchus, George R. Painter, Andres Merits, Margaret Kielian, Thomas E. Morrison

    Vydáno 2024
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  7. 7
    The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection

    The prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection Autor George R. Painter, Richard A. Bowen, Gregory R. Bluemling, John DeBergh, Vindhya Edpuganti, Prabhakar R. Gruddanti, David B. Guthrie, Michael Hager, Damien L. Kuiper, Mark A. Lockwood, Deborah G. Mitchell, Michael G. Natchus, Zachary M. Sticher, Alexander A. Kolykhalov

    Vydáno 2019
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  8. 8
    4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication

    4′-Fluorouridine is an oral antiviral that blocks respiratory syncytial virus and SARS-CoV-2 replication Autor Julien Sourimant, Carolin M. Lieber, Megha Aggarwal, Robert M. Cox, Josef D. Wolf, Jeong-Joong Yoon, Märt Toots, Chengjin Ye, Zachary M. Sticher, Alexander A. Kolykhalov, Luis Martínez‐Sobrido, Gregory R. Bluemling, Michael G. Natchus, George R. Painter, Richard K. Plemper

    Vydáno 2022
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  9. 9
    SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model

    SARS-CoV-2 VOC type and biological sex affect molnupiravir efficacy in severe COVID-19 dwarf hamster model Autor Carolin M. Lieber, Robert M. Cox, Julien Sourimant, Josef D. Wolf, Kate B. Juergens, Quynh Phung, Manohar Saindane, Meghan K. Smith, Zachary M. Sticher, Alexander A. Kalykhalov, Michael G. Natchus, George R. Painter, Kaori Sakamoto, Alexander L. Greninger, Richard K. Plemper

    Vydáno 2022
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  10. 10
    Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists

    Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists Autor Valarie M. Truax, Huanyu Zhao, Brooke M. Katzman, Anthony R. Prosser, Ana A. Alcaraz, Manohar Saindane, Randy B. Howard, Deborah G. Culver, Richard F. Arrendale, Prahbakar R. Gruddanti, Taylor J. Evers, Michael G. Natchus, James P. Snyder, Dennis C. Liotta, Lawrence J. Wilson

    Vydáno 2013
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  11. 11
    Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models

    Comparing molnupiravir and nirmatrelvir/ritonavir efficacy and the effects on SARS-CoV-2 transmission in animal models Autor Robert M. Cox, Carolin M. Lieber, Josef D. Wolf, Amir-Hossein Karimi, Nicole A. P. Lieberman, Zachary M. Sticher, Pavitra Roychoudhury, Meghan K. Andrews, Rebecca E. Krueger, Michael G. Natchus, George R. Painter, Alexander A. Kolykhalov, Alexander L. Greninger, Richard K. Plemper

    Vydáno 2023
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  12. 12
    Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia

    Characterization of orally efficacious influenza drug with high resistance barrier in ferrets and human airway epithelia Autor Märt Toots, Jeong-Joong Yoon, Robert M. Cox, M. N. Hart, Zachary M. Sticher, Negar Makhsous, Roland Plesker, Alec H. Barrena, Prabhakar Reddy, Deborah G. Mitchell, Ryan C. Shean, Gregory R. Bluemling, Alexander A. Kolykhalov, Alexander L. Greninger, Michael G. Natchus, George R. Painter, Richard K. Plemper

    Vydáno 2019
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  13. 13
    4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

    4’-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses Autor Carolin M. Lieber, Megha Aggarwal, Jeong-Joong Yoon, Robert M. Cox, Hae-Ji Kang, Julien Sourimant, Märt Toots, Scott K. Johnson, Cheryl A. Jones, Zachary M. Sticher, Alexander A. Kolykhalov, Manohar Saindane, S. Mark Tompkins, Oliver Planz, George R. Painter, Michael G. Natchus, Kaori Sakamoto, Richard K. Plemper

    Vydáno 2023
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  14. 14
    Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine

    Modeling Heartland virus disease in mice and therapeutic intervention with 4′-fluorouridine Autor Jonna B. Westover, Kie Hoon Jung, Cigdem Alkan, Kirsten M. Boardman, Arnaud J. Van Wettere, Craig Martens, Inioska Rojas, Philip Hicks, Aaron J. Thomas, Manohar Saindane, Gregory R. Bluemling, Shuli Mao, Alexander A. Kolykhalov, Michael G. Natchus, Paul Bates, George R. Painter, Tetsuro Ikegami, Brian B. Gowen

    Vydáno 2024
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  15. 15
    Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses

    Orally Efficacious Broad-Spectrum Ribonucleoside Analog Inhibitor of Influenza and Respiratory Syncytial Viruses Autor Jeong-Joong Yoon, Märt Toots, Sujin Lee, Myungeun Lee, Barbara Ludeke, Jasmina M. Luczo, Ketaki Ganti, Robert M. Cox, Zachary M. Sticher, Vindya Edpuganti, Deborah G. Mitchell, Mark A. Lockwood, Alexander A. Kolykhalov, Alexander L. Greninger, Martin L. Moore, George R. Painter, Anice C. Lowen, S. Mark Tompkins, Rachel Fearns, Michael G. Natchus, Richard K. Plemper

    Vydáno 2018
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  16. 16
    SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801

    SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801 Autor Angela Wahl, Lisa E. Gralinski, Claire Johnson, Wenbo Yao, Martina Kovářová, Kenneth H. Dinnon, Hongwei Liu, Victoria J. Madden, Halina Krzystek, Chandrav De, Kristen White, Kendra L. Gully, Alexandra Schäfer, Tanzila Zaman, Sarah R. Leist, P. Grant, Gregory R. Bluemling, Alexander A. Kolykhalov, Michael G. Natchus, Frederic B. Askin, George R. Painter, Edward P. Browne, Corbin D. Jones, Raymond J. Pickles, Ralph S. Baric, J. Víctor García

    Vydáno 2021
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  17. 17
    An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice

    An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice Autor Timothy P. Sheahan, Amy Sims, Shuntai Zhou, Rachel L. Graham, Andrea J. Pruijssers, Maria L. Agostini, Sarah R. Leist, Alexandra Schäfer, Kenneth H. Dinnon, Laura J. Stevens, James D. Chappell, Xiaotao Lu, Tia M. Hughes, Amelia S. George, Collin S Hill, Stephanie A. Montgomery, Ariane J. Brown, Gregory R. Bluemling, Michael G. Natchus, Manohar Saindane, Alexander A. Kolykhalov, George R. Painter, Jennifer L. Harcourt, Azaibi Tamin, Natalie J. Thornburg, Ronald Swanstrom, Mark R. Denison, Ralph S. Baric

    Vydáno 2020
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