Search Results - Michael E. Pacold

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  1. 1
    Using a Small Molecule Inhibitor of Peptide: N-Glycanase to Probe Its Role in Glycoprotein Turnover

    Using a Small Molecule Inhibitor of Peptide: N-Glycanase to Probe Its Role in Glycoprotein Turnover by Shahram Misaghi, Michael E. Pacold, Daniël Blom, Hidde L. Ploegh, Gregory A. Korbel

    Published 2004
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  2. 2
    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain by Lynne Chantranupong, Jessica L. Saulnier, Wengang Wang, Drew R. Jones, Michael E. Pacold, Bernardo L. Sabatini

    Published 2020
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  3. 3
    Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

    Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine by Edward H. Walker, Michael E. Pacold, Olga Perišić, Len Stephens, Phillip T. Hawkins, Matthias P. Wymann, Roger Williams

    Published 2000
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  4. 4
    Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

    Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway by Robert A. Saxton, Kevin E. Knockenhauer, Rachel L. Wolfson, Lynne Chantranupong, Michael E. Pacold, Timothy C. Wang, Thomas Schwartz, David M. Sabatini

    Published 2015
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  5. 5
    Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

    Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ by Michael E. Pacold, Sabine Suire, Olga Perišić, Samuel Lara‐González, Colin Davis, Edward H. Walker, Phillip T. Hawkins, Len Stephens, John F. Eccleston, Roger Williams

    Published 2000
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  6. 6
    mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

    mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin by Seong A. Kang, Michael E. Pacold, Christopher Cervantes, Daniel Lim, Hua Jane Lou, Kathleen Ottina, Nathanael S. Gray, Benjamin E. Turk, Michael B. Yaffe, David M. Sabatini

    Published 2013
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  7. 7
    The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway

    The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway by Robert S. Banh, Esther Kim, Quentin Spillier, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Guangbin Shi, Drew R. Jones, Alec C. Kimmelman, Michael E. Pacold

    Published 2021
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  8. 8
    Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery

    Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery by Shrirang Karve, Michael E. Werner, Rohit Sukumar, Natalie D. Cummings, Jonathan A. Copp, Edina C. Wang, Chenxi Li, Manish Sethi, Ronald C. Chen, Michael E. Pacold, Andrew Z. Wang

    Published 2012
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  9. 9
    The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate

    The Crystal Structure of the PX Domain from p40phox Bound to Phosphatidylinositol 3-Phosphate by Jerónimo Bravo, Dimitrios Karathanassis, Christine M Pacold, Michael E. Pacold, Chris D. Ellson, Karen E. Anderson, P.J.G. Butler, Isabelle Lavenir, Olga Perišić, Phillip T. Hawkins, Len Stephens, Roger Williams

    Published 2001
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  10. 10
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer by Robert S. Banh, Douglas E. Biancur, Keisuke Yamamoto, Albert S.W. Sohn, Beth Walters, Miljan Kuljanin, Ajami Gikandi, Huamin Wang, Joseph D. Mancias, Robert J. Schneider, Michael E. Pacold, Alec C. Kimmelman

    Published 2020
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  11. 11
    SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism

    SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism by Nora Kory, Gregory A. Wyant, Gyan Prakash, Jelmi uit de Bos, Francesca Bottanelli, Michael E. Pacold, Sze Ham Chan, Caroline A. Lewis, Timothy C. Wang, Heather R. Keys, Yang Guo, David M. Sabatini

    Published 2018
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  12. 12
    Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

    Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors by Jason M. Rohde, Kyle R. Brimacombe, Li Liu, Michael E. Pacold, Adam Yasgar, Dorian M. Cheff, Tobie D. Lee, Ganesha Rai, Bolormaa Baljinnyam, Zhuyin Li, Anton Simeonov, Matthew D. Hall, Min Shen, David M. Sabatini, Matthew B. Boxer

    Published 2018
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  13. 13
    Unravelling cysteine-deficiency-associated rapid weight loss

    Unravelling cysteine-deficiency-associated rapid weight loss by Alan Varghese, Ivan Gusarov, Begoña Gamallo-Lana, Daria Dolgonos, Yatin Mankan, Ilya Shamovsky, Mydia Phan, Rebecca Jones, Maria Laura Gomez, Eileen White, Rui Wang, Drew R. Jones, Thales Papagiannakopoulos, Michael E. Pacold, Adam C. Mar, Dan R. Littman, Evgeny Nudler

    Published 2025
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  14. 14
    Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

    Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition by Yoav D. Shaul, Elizaveta Freinkman, William C. Comb, Jason R. Cantor, Wai Leong Tam, Prathapan Thiru, Do‐Hoon Kim, Naama Kanarek, Michael E. Pacold, Walter W. Chen, Brian Bierie, Richard Possemato, Ferenc Reinhardt, Robert A. Weinberg, Michael B. Yaffe, David M. Sabatini

    Published 2014
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  15. 15
    Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

    Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy by Lin Wu, Kate E.R. Hollinshead, Yuhan Hao, Christy Au, Lina Kroehling, Charles Ng, Woan-Yu Lin, Dayi Li, Hernandez Moura Silva, Jong Shin, Juan J. Lafaille, Richard Possemato, Michael E. Pacold, Thales Papagiannakopoulos, Alec C. Kimmelman, Rahul Satija, Dan R. Littman

    Published 2020
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  16. 16
    Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor

    Therapeutic Targeting of Oncogenic K‐Ras by a Covalent Catalytic Site Inhibitor by Sang Min Lim, Kenneth D. Westover, Scott B. Ficarro, Rane A. Harrison, Hwan Geun Choi, Michael E. Pacold, Martin A. Carrasco, John C. Hunter, Nam Doo Kim, Ting Xie, Taebo Sim, Pasi A. Jänne, Matthew Meyerson, Jarrod A. Marto, John R. Engen, Nathanael S. Gray

    Published 2013
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  17. 17
    Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes

    Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes by Ravi V. Shah, Venkatesh L. Murthy, Michael E. Pacold, Kirsty Danielson, Kahraman Tanrıverdi, Martin G. Larson, Kristina Hanspers, Alexander R. Pico, Eric Mick, Jared P. Reis, Sarah D. de Ferranti, Elizaveta Freinkman, Daniel Levy, Udo Hoffmann, Stavroula K. Osganian, Saumya Das, Jane E. Freedman

    Published 2017
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  18. 18
    Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

    Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites by Schraga Schwartz, Maxwell R. Mumbach, Marko Jovanović, Timothy C. Wang, Karolina Maciag, G. Guy Bushkin, Philipp Mertins, Dmitry Ter‐Ovanesyan, Naomi Habib, Davide Cacchiarelli, Neville E. Sanjana, Elizaveta Freinkman, Michael E. Pacold, Rahul Satija, Tarjei S. Mikkelsen, Nir Hacohen, Feng Zhang, Steven A. Carr, Eric S. Lander, Aviv Regev

    Published 2014
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  19. 19
    SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

    SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance by Do‐Hoon Kim, Brian P. Fiske, Kıvanç Birsoy, Elizaveta Freinkman, Kenjiro Kami, Richard Possemato, Yakov Chudnovsky, Michael E. Pacold, Walter W. Chen, Jason R. Cantor, Laura M. Shelton, Dan Y. Gui, Manjae Kwon, Shakti Ramkissoon, Keith L. Ligon, Seong Woo Kang, Matija Snuderl, Matthew G. Vander Heiden, David M. Sabatini

    Published 2015
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  20. 20
    <i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase

    <i>PIK3CA</i> mutant tumors depend on oxoglutarate dehydrogenase by Nina Ilić, Kıvanç Birsoy, Andrew J. Aguirre, Nora Kory, Michael E. Pacold, Shambhavi Singh, Susan E. Moody, Joseph D. DeAngelo, Nicole A. Spardy, Elizaveta Freinkman, Barbara A. Weir, Aviad Tsherniak, Glenn S. Cowley, David E. Root, John M. Asara, Francisca Vázquez, Hans R. Widlund, David M. Sabatini, William C. Hahn

    Published 2017
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