Search Results - Melissa McAlonis‐Downes

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  1. 1
    Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice

    Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice by Christian S. Lobsiger, Séverine Boillée, Melissa McAlonis‐Downes, Amir M. Khan, M. Laura Feltri, Koji Yamanaka, Don W. Cleveland

    Published 2009
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  2. 2
    C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

    C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice by Christian S. Lobsiger, Séverine Boillée, Christine D. Pozniak, Amir M. Khan, Melissa McAlonis‐Downes, Joseph W. Lewcock, Don W. Cleveland

    Published 2013
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  3. 3
    Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotrophic Lateral Sclerosis

    Enhancing Mitochondrial Calcium Buffering Capacity Reduces Aggregation of Misfolded SOD1 and Motor Neuron Cell Death without Extending Survival in Mouse Models of Inherited Amyotro... by Philippe A. Parone, Sandrine Da Cruz, Joo Seok Han, Melissa McAlonis‐Downes, Anne P. Vetto, Sandra K. Lee, Eva Tseng, Don W. Cleveland

    Published 2013
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  4. 4
    Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

    Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice by Koji Yamanaka, Séverine Boillée, Elizabeth A. Roberts, Michael L. Garcia, Melissa McAlonis‐Downes, Oliver R. Mikse, Don W. Cleveland, Lawrence S.B. Goldstein

    Published 2008
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  5. 5
    Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset

    Misfolded SOD1 Associated with Motor Neuron Mitochondria Alters Mitochondrial Shape and Distribution Prior to Clinical Onset by Christine Vande Velde, Karli K. McDonald, Yasmin Boukhedimi, Melissa McAlonis‐Downes, Christian S. Lobsiger, Samar Bel Hadj, Andre Zandona, Jean‐Pierre Julien, Sameer B. Shah, Don W. Cleveland

    Published 2011
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  6. 6
    Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis

    Mutant TDP-43 within motor neurons drives disease onset but not progression in amyotrophic lateral sclerosis by Dara Ditsworth, Marcus Maldonado, Melissa McAlonis‐Downes, Shuying Sun, Amanda Seelman, Kevin Drenner, Eveline S. Arnold, Shuo‐Chien Ling, Donald Pizzo, John Ravits, Don W. Cleveland, Sandrine Da Cruz

    Published 2017
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  7. 7
    Misfolded SOD1 is not a primary component of sporadic ALS

    Misfolded SOD1 is not a primary component of sporadic ALS by Sandrine Da Cruz, Anh Thu Bui, Shahram Saberi, Sandra K. Lee, Jennifer E. Stauffer, Melissa McAlonis‐Downes, Derek Schulte, Donald Pizzo, Philippe A. Parone, Don W. Cleveland, John Ravits

    Published 2017
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  8. 8
    Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB

    Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB by Roy Maimon, Carlos Chillón-Marinas, Cedric E. Snethlage, Sarthak M. Singhal, Melissa McAlonis‐Downes, Karen Ling, Frank Rigo, C. Frank Bennett, Sandrine Da Cruz, Thomas S. Hnasko, Alysson R. Muotri, Don W. Cleveland

    Published 2021
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  9. 9
    Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

    Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS by Shuying Sun, Ying Sun, Shuo‐Chien Ling, Laura Ferraiuolo, Melissa McAlonis‐Downes, Yiyang Zou, Kevin Drenner, Yin Wang, Dara Ditsworth, Seiya Tokunaga, Alex Kopelevich, Brian K. Kaspar, Clotilde Lagier‐Tourenne, Don W. Cleveland

    Published 2015
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  10. 10
    Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS

    Elevated PGC-1α Activity Sustains Mitochondrial Biogenesis and Muscle Function without Extending Survival in a Mouse Model of Inherited ALS by Sandrine Da Cruz, Philippe A. Parone, Vanda S. Lopes, Concepción Lillo, Melissa McAlonis‐Downes, Sandra K. Lee, Anne P. Vetto, Susanna Petrosyan, Martin Maršala, Anne N. Murphy, David S. Williams, Bruce M. Spiegelman, Don W. Cleveland

    Published 2012
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  11. 11
    Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1

    Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1 by Adrian Israelson, Dara Ditsworth, Shuying Sun, SungWon Song, Jason Liang, Marián Hruška-Plocháň, Melissa McAlonis‐Downes, Salah Abu‐Hamad, Guy Zoltsman, Tom Shani, Marcus Maldonado, Anh Thu Bui, Michael Navarro, Huilin Zhou, Martin Maršala, Brian K. Kaspar, Sandrine Da Cruz, Don W. Cleveland

    Published 2015
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  12. 12
    ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43

    ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43 by Eveline S. Arnold, Shuo‐Chien Ling, Stephanie C. Huelga, Clotilde Lagier‐Tourenne, Magdalini Polymenidou, Dara Ditsworth, Holly Kordasiewicz, Melissa McAlonis‐Downes, Oleksandr Platoshyn, Philippe A. Parone, Sandrine Da Cruz, Kevin M. Clutario, Debbie Swing, Lino Tessarollo, Martin Maršala, Christopher E. Shaw, G Yeo, Don W. Cleveland

    Published 2013
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  13. 13
    Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72

    Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72 by Qiang Zhu, Jie Jiang, Tania F. Gendron, Melissa McAlonis‐Downes, Lu-Lin Jiang, Amy E. Taylor, Sandra Diaz Garcia, Somasish Ghosh Dastidar, Maria José Gómez-Rodríguez, Patrick King, Yong‐Jie Zhang, Albert R. La Spada, Huaxi Xu, Leonard Petrucelli, John Ravits, Sandrine Da Cruz, Clotilde Lagier‐Tourenne, Don W. Cleveland

    Published 2020
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  14. 14
    Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS

    Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS by Mariana Bravo‐Hernández, Takahiro Tadokoro, Michael Navarro, Oleksandr Platoshyn, Yoshiomi Kobayashi, Silvia Marsala, Atsushi Miyanohara, Štefan Juhás, Jana Juhásová, Helena Kupcová Skalníková, Z Tomori, Ivo Vanický, Hana Studenovská, Vladimír Proks, Peixi Chen, Noé Govea-Perez, Dara Ditsworth, Joseph D. Ciacci, Shang Gao, Wenlian Zhu, Eric T. Ahrens, Shawn P. Driscoll, Thomas D. Glenn, Melissa McAlonis‐Downes, Sandrine Da Cruz, Samuel L. Pfaff, Brian K. Kaspar, Don W. Cleveland, Martin Maršala

    Published 2019
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  15. 15
    Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation

    Stathmin-2 loss leads to neurofilament-dependent axonal collapse driving motor and sensory denervation by Jone López‐Erauskin, Mariana Bravo‐Hernández, Maximiliano Presa, Michael W. Baughn, Ze’ev Melamed, Melinda S. Beccari, Ana Rita Agra de Almeida Quadros, Olatz Arnold-García, Aamir Zuberi, Karen Ling, Oleksandr Platoshyn, Elkin Niño-Jara, I. Sandra Ndayambaje, Melissa McAlonis‐Downes, Larissa Cabrera, Jonathan W. Artates, Jennifer Ryan, Anita Hermann, John Ravits, C. Frank Bennett, Paymaan Jafar‐Nejad, Frank Rigo, Martin Maršala, Cathleen Lutz, Don W. Cleveland, Clotilde Lagier‐Tourenne

    Published 2023
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  16. 16
    Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration

    Targeted degradation of sense and antisense <i>C9orf72</i> RNA foci as therapy for ALS and frontotemporal degeneration by Clotilde Lagier‐Tourenne, Michael W. Baughn, Frank Rigo, Shuying Sun, Patrick Liu, Hairi Li, Jie Jiang, Andrew T. Watt, Seung Chun, Melanie Katz, Jinsong Qiu, Ying Sun, Shuo‐Chien Ling, Qiang Zhu, Magdalini Polymenidou, Kevin Drenner, Jonathan W. Artates, Melissa McAlonis‐Downes, Sebastian Markmiller, Kasey R. Hutt, Donald Pizzo, Janet Cady, Matthew B. Harms, Robert H. Baloh, Scott R. VandenBerg, G Yeo, Xiang‐Dong Fu, C. Frank Bennett, Don W. Cleveland, John Ravits

    Published 2013
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  17. 17
    ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

    ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS by Jone López‐Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian E. Myers, Melissa McAlonis‐Downes, Carlos Chillón-Marinas, Joshua N. Asiaban, Jonathan W. Artates, Anh Thu Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Mélanie Jambeau, Jihane Boubaker, Deborah A. Swing, Jinsong Qiu, Geoffrey G. Hicks, Zhengyu Ouyang, Xiang‐Dong Fu, Lino Tessarollo, Shuo‐Chien Ling, Philippe A. Parone, Christopher E. Shaw, Martin Maršala, Clotilde Lagier‐Tourenne, Don W. Cleveland, Sandrine Da Cruz

    Published 2018
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  18. 18
    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis by Shuo‐Chien Ling, Somasish Ghosh Dastidar, Seiya Tokunaga, Wan Yun Ho, Kenneth Teck Kiat Lim, Hristelina Ilieva, Philippe A. Parone, Sheue-Houy Tyan, Tsemay M. Tse, Jer-Cherng Chang, Oleksandr Platoshyn, Ngoc B Bui, Anh Thu Bui, Anne P. Vetto, Shuying Sun, Melissa McAlonis‐Downes, Joo Seok Han, Debbie Swing, Katannya Kapeli, G Yeo, Lino Tessarollo, Martin Maršala, Christopher E. Shaw, Greg Tucker‐Kellogg, Albert R. La Spada, Clotilde Lagier‐Tourenne, Sandrine Da Cruz, Don W. Cleveland

    Published 2019
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  19. 19
    Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

    Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs by Jie Jiang, Qiang Zhu, Tania F. Gendron, Shahram Saberi, Melissa McAlonis‐Downes, Amanda Seelman, Jennifer E. Stauffer, Paymaan Jafar‐Nejad, Kevin Drenner, Derek Schulte, Seung Chun, Shuying Sun, Shuo‐Chien Ling, Brian Myers, Jeffery A. Engelhardt, Melanie Katz, Michael W. Baughn, Oleksandr Platoshyn, Martin Maršala, Andy Watt, Charles J. Heyser, M. Colin Ard, Louis De Muynck, Lillian M. Daughrity, Deborah A. Swing, Lino Tessarollo, Chris Jung, Arnaud Delpoux, Daniel T. Utzschneider, Stephen Μ. Hedrick, Pieter J. de Jong, Dieter Edbauer, Philip Van Damme, Leonard Petrucelli, Christopher E. Shaw, C. Frank Bennett, Sandrine Da Cruz, John Ravits, Frank Rigo, Don W. Cleveland, Clotilde Lagier‐Tourenne

    Published 2016
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