Search Results - Matthew P. Coghlan

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  1. 1
    Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

    Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells by Maria Watson, Matthew P. Coghlan, Harinder S. Hundal

    Published 2008
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  2. 2
    Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss

    Atypical Protein Kinases Cλ and -ζ Associate with the GTP-Binding Protein Cdc42 and Mediate Stress Fiber Loss by Matthew P. Coghlan, Margaret M. Chou, Christopher L. Carpenter

    Published 2000
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  3. 3
    How May GIP Enhance the Therapeutic Efficacy of GLP-1?

    How May GIP Enhance the Therapeutic Efficacy of GLP-1? by Ricardo J. Samms, Matthew P. Coghlan, Kyle W. Sloop

    Published 2020
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  4. 4
    Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression

    Inhibition of GSK-3 Selectively Reduces Glucose-6-Phosphatase and Phosphoenolpyruvate Carboxykinase Gene Expression by Pamela A. Lochhead, Matthew P. Coghlan, Simon Q.J. Rice, Calum Sutherland

    Published 2001
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  5. 5
    c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

    c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor by Gerhard Behre, Alan J. Whitmarsh, Matthew P. Coghlan, Trang Hoang, Christopher L. Carpenter, Dong‐Er Zhang, Roger J. Davis, Daniel G. Tenen

    Published 1999
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  6. 6
    Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats

    Predictive blood glucose lowering efficacy by Glucokinase activators in high fat fed female Zucker rats by Gareth Coope, A M Atkinson, C Allott, Darren McKerrecher, Craig Johnstone, Kurt G. Pike, Petter Holme, Helen L. Vertigan, Débora Gil, Matthew P. Coghlan, Brendan Leighton

    Published 2006
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  7. 7
    Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators

    Stimulation of Hepatocyte Glucose Metabolism by Novel Small Molecule Glucokinase Activators by Katy J. Brocklehurst, Victoria A. Payne, Rick A. Davies, Debra Carroll, Helen L. Vertigan, Heather J. Wightman, Susan Aiston, Ian D. Waddell, Brendan Leighton, Matthew P. Coghlan, Loranne Agius

    Published 2004
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  8. 8
    Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist

    Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist by Takahiro Kawai, Bingfa Sun, Hitoshi Yoshino, Dan Feng, Yoshiyuki Suzuki, Masanori Fukazawa, Shunsuke Nagao, David B. Wainscott, Aaron D. Showalter, Brian A. Droz, Tong Sun Kobilka, Matthew P. Coghlan, Francis S. Willard, Yoshiki Kawabe, Brian K. Kobilka, Kyle W. Sloop

    Published 2020
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  9. 9
    Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription

    Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription by Matthew P. Coghlan, Ainsley A. Culbert, Darren A.E. Cross, Stacey L. Corcoran, John Yates, Neil Pearce, Oliver Rausch, Gregory Murphy, Paul S. Carter, Lynne Roxbee Cox, David Mills, Murray J. B. Brown, David Haigh, Robert W. Ward, David G. Smith, Kenneth Murray, Alastair D. Reith, Julie C. Holder

    Published 2000
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  10. 10
    Robust anti‐obesity and metabolic effects of a dual <scp>GLP</scp>‐1/glucagon receptor peptide agonist in rodents and non‐human primates

    Robust anti‐obesity and metabolic effects of a dual <scp>GLP</scp>‐1/glucagon receptor peptide agonist in rodents and non‐human primates by Susan Henderson, Anish Konkar, David C. Hornigold, James L. Trevaskis, Robert N Jackson, Maria Fritsch Fredin, Rasmus Jansson‐Löfmark, Jacqui Naylor, Alessandra Rossi, Maria A. Bednarek, Nicholas Bhagroo, H. Salari, Sarah Will, Stephanie Oldham, Gitte Hansen, Michael Feigh, Thomas Klein, Joseph Grimsby, Shaun Maguire, Lutz Jermutus, Cristina M. Rondinone, Matthew P. Coghlan

    Published 2016
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  11. 11
    Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

    Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist by Francis S. Willard, Jonathan D. Douros, M Gabe, Aaron D. Showalter, David B. Wainscott, Todd M. Suter, Megan E. Capozzi, Wijnand J. C. van der Velden, Cynthia Stutsman, Guemalli R. Cardona, Shweta Urva, Paul J. Emmerson, Jens J. Holst, David A. D’Alessio, Matthew P. Coghlan, Mette M. Rosenkilde, Jonathan E. Campbell, Kyle W. Sloop

    Published 2020
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  12. 12
    Structural determinants of dual incretin receptor agonism by tirzepatide

    Structural determinants of dual incretin receptor agonism by tirzepatide by Bingfa Sun, Francis S. Willard, Dan Feng, Jorge Alsina‐Fernandez, Qi Chen, Michal Vieth, Joseph D. Ho, Aaron D. Showalter, Cynthia Stutsman, Liyun Ding, Todd M. Suter, James D. Dunbar, John W. Carpenter, Faiz Ahmad Mohammed, Eitaro Aihara, Robert A. Brown, Ana B. Bueno, Paul J. Emmerson, Julie S. Moyers, Tong Sun Kobilka, Matthew P. Coghlan, Brian K. Kobilka, Kyle W. Sloop

    Published 2022
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  13. 13
    GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice

    GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice by Ricardo J. Samms, Michael E. Christe, Kyla Collins, Valentina Pirro, Brian A. Droz, Adrienne K. Holland, Jessica L. Friedrich, Samantha Wojnicki, Debra L. Konkol, Richard Cosgrove, Ellen Paula Santos da Conceição, Xiaoping Ruan, Libbey S. O’Farrell, Annie M. Long, Mridula Dogra, Jill A. Willency, Yanzhu Lin, Liyun Ding, Christine C. Cheng, Over Cabrera, Daniel A. Briere, Jorge Alsina‐Fernandez, Ruth E. Gimeno, Julie S. Moyers, Tamer Coşkun, Matthew P. Coghlan, Kyle W. Sloop, William C. Roell

    Published 2021
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  14. 14
    Glucose-dependent insulinotropic polypeptide (GIP)

    Glucose-dependent insulinotropic polypeptide (GIP) by Timo D. Müller, Alice E. Adriaenssens, Bo Ahrén, Matthias Blüher, Andreas L. Birkenfeld, Jonathan E. Campbell, Matthew P. Coghlan, David D’Alessio, Carolyn F. Deacon, Stefano DelPrato, Jonathan D. Douros, D J Drucker, N. Burgos, Peter R. Flatt, Brian Finan, Ruth E. Gimeno, Fiona M. Gribble, Matthew R. Hayes, Christian Hölscher, Jens J. Holst, Patrick J. Knerr, Filip K. Knop, Christine M. Kusminski, Arkadiusz Liśkiewicz, Guillaume Mabilleau, Stephanie A. Mowery, Michael A. Nauck, Aaron Novikoff, Frank Reimann, Anna G. Roberts, Mette M. Rosenkilde, Ricardo J. Samms, Philip E Scherer, Randy J. Seeley, Kyle W. Sloop, Christian Wolfrum, Denise Wootten, Richard D. DiMarchi, Matthias H. Tschöp

    Published 2025
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