Søgeresultater - Martin A. Maier

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  1. 1
    Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells

    Activity of Plasma Membrane V-ATPases Is Critical for the Invasion of MDA-MB231 Breast Cancer Cells af Kristina Cotter, Joseph Capecci, Souad Sennoune, Markus Huss, Martin A. Maier, Raul Martı́nez–Zaguilán, Michael Forgac

    Udgivet 2014
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  2. 2
    Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs

    Nuclear antisense effects of neutral, anionic and cationic oligonucleotide analogs af Peter Sazani, Shin-Hong Kang, Martin A. Maier, Changfu Wei, Jennifer Dillman, James E. Summerton, Muthiah Manoharan, Ryszard Kole

    Udgivet 2001
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  3. 3
    Sequence‐Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications

    Sequence‐Defined Oligomers from Hydroxyproline Building Blocks for Parallel Synthesis Applications af Rosemary Kanasty, Arturo J. Vegas, Luke M. Ceo, Martin A. Maier, Klaus Charissé, Jayaprakash K. Nair, Róbert Langer, Daniel G. Anderson

    Udgivet 2016
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  4. 4
    An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema

    An investigational RNAi therapeutic targeting Factor XII (ALN-F12) for the treatment of hereditary angioedema af Jingxuan Liu, June Qin, Anna Borodovsky, Timothy Racie, Adam Castoreno, Mark K. Schlegel, Martin A. Maier, Tracy Zimmerman, Kevin Fitzgerald, James Butler, Akin Akinc

    Udgivet 2018
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  5. 5
    Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

    Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates af Donald J. Foster, Christopher R. Brown, Sarfraz Shaikh, Casey Trapp, Mark K. Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G. Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A. Maier, Stuart Milstein

    Udgivet 2018
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  6. 6
    Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs

    Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs af Muthiah Manoharan, Akin Akinc, Rajendra K. Pandey, June Qin, Philipp Hadwiger, Matthias John, Kathy Mills, Klaus Charissé, Martin A. Maier, Lubomir V. Nechev, Emily M. Greene, Pradeep S. Pallan, Eriks Rozners, Kallanthottathil G. Rajeev, Martin Egli

    Udgivet 2011
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  7. 7
    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides

    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides af Alexander V. Kel’in, Ivan Zlatev, Joel M. Harp, Muthusamy Jayaraman, Anna Bisbe, Jonathan O′Shea, Nate Taneja, Rajar M. Manoharan, Saeed I. Khan, Klaus Charissé, Martin A. Maier, Martin Egli, Kallanthottathil G. Rajeev, Muthiah Manoharan

    Udgivet 2016
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  8. 8
    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver af Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson

    Udgivet 2009
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  9. 9
    Modulation of thermal stability can enhance the potency of siRNA

    Modulation of thermal stability can enhance the potency of siRNA af Haripriya Addepalli, Meena Meena, Chang G. Peng, Guanghui Wang, Yi Fan, Klaus Charissé, K. N. Jayaprakash, Kallanthottathil G. Rajeev, Raj Kumar Pandey, Gary Lavine, Lei Zhang, Kerstin Jahn‐Hofmann, Philipp Hadwiger, Muthiah Manoharan, Martin A. Maier

    Udgivet 2010
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  10. 10
    Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

    Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification af Amy Chan, Abigail Liebow, Makiko Yasuda, Lin Gan, Tim Racie, Martin A. Maier, Satya Kuchimanchi, Don Foster, Stuart Milstein, Klaus Charissé, Alfica Sehgal, Muthiah Manoharan, Rachel Meyers, Kevin Fitzgerald, Amy Simon, Robert J. Desnick, William Querbes

    Udgivet 2015
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  11. 11
    Identification of siRNA delivery enhancers by a chemical library screen

    Identification of siRNA delivery enhancers by a chemical library screen af Jérôme Gilleron, Prasath Paramasivam, Anja Zeigerer, William Querbes, Giovanni Marsico, Cordula Andree, Sarah Seifert, Pablo Amaya, Martin Stöter, Victor Koteliansky, Herbert Waldmann, Kevin Fitzgerald, Yannis Kalaidzidis, Akin Akinc, Martin A. Maier, Muthiah Manoharan, Marc Bickle, Marino Zerial

    Udgivet 2015
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  12. 12
    Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

    Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity af Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga‐Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie Keirstead, Martin A. Maier, Vasant Jadhav

    Udgivet 2018
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  13. 13
    Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology <i>in vivo</i>

    Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology <i>in vivo</i> af Hartmut Jahns, Nate Taneja, Jennifer L. S. Willoughby, Masaaki Akabane‐Nakata, Christopher R. Brown, Tuyen Nguyen, Anna Bisbe, Shigeo Matsuda, Matt Hettinger, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Martin A. Maier, Ivan Zlatev, Klaus Charissé, Martin Egli, Muthiah Manoharan

    Udgivet 2021
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  14. 14
    Centyrin ligands for extrahepatic delivery of siRNA

    Centyrin ligands for extrahepatic delivery of siRNA af Donna Klein, Shalom D. Goldberg, Christopher S. Theile, Richard Dambra, Kathleen Haskell, Elise Kuhar, Tricia Lin, Rubina Parmar, Muthiah Manoharan, Mark C. Richter, Mei‐Zhen Wu, Jeannine Mendrola Zarazowski, Vasant Jadhav, Martin A. Maier, Laura Sepp‐Lorenzino, Karyn T. O’Neil, Vadim Dudkin

    Udgivet 2021
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  15. 15
    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression af Jennifer L. S. Willoughby, Amy Chan, Alfica Sehgal, James S. Butler, Jayaprakash K. Nair, Tim Racie, Svetlana Shulga‐Morskaya, Tuyen Nguyen, Kun Qian, Kristina Yucius, Klaus Charissé, Theo J.C. van Berkel, Muthiah Manoharan, Kallanthottathil G. Rajeev, Martin A. Maier, Vasant Jadhav, Tracy Zimmermann

    Udgivet 2017
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  16. 16
    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles af Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope

    Udgivet 2013
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  17. 17
    RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy

    RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy af Rene Alvarez, Sayda M. Elbashir, Todd Borland, Ivanka Toudjarska, Philipp Hadwiger, M John, Ingo Roehl, Svetlana Shulga Morskaya, Rick Martinello, Jeffrey S. Kahn, Marc Van Ranst, Ralph A. Tripp, John P. DeVincenzo, Rajendra K. Pandey, Martin A. Maier, Lubomir V. Nechev, Muthiah Manoharan, Victor Kotelianski, Rachel Meyers

    Udgivet 2009
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  18. 18
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** af Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    Udgivet 2012
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  19. 19
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** af Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    Udgivet 2012
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  20. 20
    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates af Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier

    Udgivet 2017
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