Search Results - Markus J. van Roosmalen

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  1. 1
    MutationalPatterns: the one stop shop for the analysis of mutational processes

    MutationalPatterns: the one stop shop for the analysis of mutational processes by Freek Manders, Arianne M. Brandsma, Jurrian K. de Kanter, Mark Verheul, Rurika Oka, Markus J. van Roosmalen, Bastiaan van der Roest, Arne van Hoeck, Edwin Cuppen, Ruben van Boxtel

    Published 2022
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  2. 2
    Chromothripsis in Healthy Individuals Affects Multiple Protein-Coding Genes and Can Result in Severe Congenital Abnormalities in Offspring

    Chromothripsis in Healthy Individuals Affects Multiple Protein-Coding Genes and Can Result in Severe Congenital Abnormalities in Offspring by Mirjam S. de Pagter, Markus J. van Roosmalen, Annette F. Baas, Ivo Renkens, Karen Duran, Ellen van Binsbergen, Masoumeh Tavakoli‐Yaraki, Ron Hochstenbach, Lars T. van der Veken, Edwin Cuppen, Wigard P. Kloosterman

    Published 2015
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  3. 3
    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells

    Micronuclei-based model system reveals functional consequences of chromothripsis in human cells by Maja Kneissig, Kristina Keuper, Mirjam S. de Pagter, Markus J. van Roosmalen, Jana Martin, Hannah Otto, Verena Passerini, Aline Campos Sparr, Ivo Renkens, Fenna Kropveld, Anand Vasudevan, Jason M. Sheltzer, Wigard P. Kloosterman, Zuzana Štorchová

    Published 2019
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  4. 4
    Direct detection of 8-oxo-dG using nanopore sequencing

    Direct detection of 8-oxo-dG using nanopore sequencing by Marc Pagès-Gallego, Daan M. K. van Soest, Nicolle Besselink, Roy Straver, Janneke P. Keijer, Carlo Vermeulen, Alessio Marcozzi, Markus J. van Roosmalen, Ruben van Boxtel, Boudewijn Burgering, Tobias B. Dansen, Jeroen de Ridder

    Published 2024
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  5. 5
    Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA

    Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA by Daan M. K. van Soest, Paulien E. Polderman, Wytze T. F. den Toom, Janneke P. Keijer, Markus J. van Roosmalen, Tim Leyten, Johannes Lehmann, Susan Zwakenberg, Sasha De Henau, Ruben van Boxtel, Boudewijn Burgering, Tobias B. Dansen

    Published 2024
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  6. 6
    Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients

    Antiviral treatment causes a unique mutational signature in cancers of transplantation recipients by Jurrian K. de Kanter, Flavia Peci, Eline Bertrums, Axel K.M. Rosendahl Huber, Anaïs van Leeuwen, Markus J. van Roosmalen, Freek Manders, Mark Verheul, Rurika Oka, Arianne M. Brandsma, Marc Bierings, Mirjam E. Belderbos, Ruben van Boxtel

    Published 2021
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  7. 7
    Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing

    Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing by Christina Stangl, Sam de Blank, Ivo Renkens, Liset Westera, Tamara Verbeek, Jose Espejo Valle-Inclán, Rocío Chamorro González, Anton G. Henssen, Markus J. van Roosmalen, Ronald W. Stam, Emile E. Voest, Wigard P. Kloosterman, Gijs van Haaften, Glen R. Monroe

    Published 2020
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  8. 8
    Prenatal exposure to chemotherapy increases the mutation burden in human neonatal hematopoietic stem cells

    Prenatal exposure to chemotherapy increases the mutation burden in human neonatal hematopoietic stem cells by Ilana Struys, Carolina Velázquez, Joske Ubels, Charlotte L. LeJeune, Markus J. van Roosmalen, Axel K.M. Rosendahl Huber, Anaïs J.C.N. van Leeuwen, Wouter Bossuyt, Bernard Thienpont, Thierry Voet, Kristel Van Calsteren, Liesbeth Lenaerts, Ruben van Boxtel, Frédéric Amant

    Published 2025
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  9. 9
    Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer

    Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer by Wigard P. Kloosterman, Marlous Hoogstraat, Oscar Paling, Masoumeh Tavakoli‐Yaraki, Ivo Renkens, Joost S.P. Vermaat, Markus J. van Roosmalen, Stef van Lieshout, Isaäc J. Nijman, Wijnand Roessingh, Ruben van ‘t Slot, José van de Belt, Victor Guryev, Marco J. Koudijs, Emile E. Voest, Edwin Cuppen

    Published 2011
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  10. 10
    Mapping and phasing of structural variation in patient genomes using nanopore sequencing

    Mapping and phasing of structural variation in patient genomes using nanopore sequencing by Mircea Cretu Stancu, Markus J. van Roosmalen, Ivo Renkens, Marleen M. Nieboer, Sjors Middelkamp, Joep de Ligt, Giulia Pregno, Daniela Giachino, Giorgia Mandrile, Jose Espejo Valle-Inclán, Jerome Korzelius, Ewart de Bruijn, Edwin Cuppen, Michael E. Talkowski, Tobias Marschall, Jeroen de Ridder, Wigard P. Kloosterman

    Published 2017
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  11. 11
    Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms

    Selective pressures of platinum compounds shape the evolution of therapy-related myeloid neoplasms by Eline J.M. Bertrums, Jurrian K. de Kanter, Lucca L.M. Derks, Mark Verheul, Laurianne Trabut, Markus J. van Roosmalen, Henrik Hasle, Evangelia Antoniou, Dirk Reinhardt, Michael Dworzak, Nora Mühlegger, Marry M. van den Heuvel‐Eibrink, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel

    Published 2024
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  12. 12
    A multi-platform reference for somatic structural variation detection

    A multi-platform reference for somatic structural variation detection by Jose Espejo Valle-Inclán, Nicolle Besselink, Ewart de Bruijn, Daniel Cameron, Jana Ebler, Joachim Kutzera, Stef van Lieshout, Tobias Marschall, Marcel Nelen, Peter Priestley, Ivo Renkens, Margaretha G.M. Roemer, Markus J. van Roosmalen, Aaron M. Wenger, Bauke Ylstra, Remond J.A. Fijneman, Wigard P. Kloosterman, Edwin Cuppen

    Published 2022
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  13. 13
    Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms

    Constitutional Chromothripsis Rearrangements Involve Clustered Double-Stranded DNA Breaks and Nonhomologous Repair Mechanisms by Wigard P. Kloosterman, Masoumeh Tavakoli‐Yaraki, Markus J. van Roosmalen, Ellen van Binsbergen, Ivo Renkens, Karen Duran, Lucia Ballarati, Sarah Vergult, Daniela Giardino, Kerstin Hansson, Claudia Ruivenkamp, Myrthe Jager, Arie van Haeringen, Elly F. Ippel, Thomas Haaf, Eberhard Passarge, Ron Hochstenbach, Björn Menten, Lidia Larizza, Victor Guryev, Martin Poot, Edwin Cuppen

    Published 2012
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  14. 14
    Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms

    Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms by Eline J.M. Bertrums, Axel K.M. Rosendahl Huber, Jurrian K. de Kanter, Arianne M. Brandsma, Anaïs J.C.N. van Leeuwen, Mark Verheul, Marry M. van den Heuvel‐Eibrink, Rurika Oka, Markus J. van Roosmalen, Hester A. de Groot‐Kruseman, C. Michel Zwaan, Bianca F. Goemans, Ruben van Boxtel

    Published 2022
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  15. 15
    Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer

    Genomic and transcriptomic plasticity in treatment-naïve ovarian cancer by Marlous Hoogstraat, Mirjam S. de Pagter, Geert A. Cirkel, Markus J. van Roosmalen, Timothy T. Harkins, Karen Duran, Jennifer Kreeftmeijer, Ivo Renkens, Petronella O. Witteveen, Clarence Lee, Isaäc J. Nijman, Tanisha Guy, Ruben van ‘t Slot, Trudy N. Jonges, Martijn P. Lolkema, Marco J. Koudijs, Ronald P. Zweemer, Emile E. Voest, Edwin Cuppen, Wigard P. Kloosterman

    Published 2013
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  16. 16
    A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer

    A Systematic Analysis of Oncogenic Gene Fusions in Primary Colon Cancer by Wigard P. Kloosterman, Robert R.J. Coebergh van den Braak, Mark Pieterse, Markus J. van Roosmalen, Anieta M. Sieuwerts, Christina Stangl, Ronne Brunekreef, Zarina S. Lalmahomed, Salo Ooft, Anne van Galen, Marcel Smid, Armel Lefebvre, Fried Zwartkruis, John W.M. Martens, John A. Foekens, Katharina Biermann, Marco J. Koudijs, Jan N.M. IJzermans, Emile E. Voest

    Published 2017
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  17. 17
    Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns

    Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns by Yannik Bollen, Ellen Stelloo, Petra van Leenen, Myrna van den Bos, Bas Ponsioen, Bingxin Lu, Markus J. van Roosmalen, Ana C.F. Bolhaqueiro, Christopher Kimberley, Maximilian Mossner, William Cross, Nicolle Besselink, Bastiaan van der Roest, Sander Boymans, Koen C. Oost, Sippe G. de Vries, Holger Rehmann, Edwin Cuppen, Susanne M.A. Lens, Geert J.P.L. Kops, Wigard P. Kloosterman, Leon W.M.M. Terstappen, C. Barnes, Andrea Sottoriva, Trevor A. Graham, Hugo J.G. Snippert

    Published 2021
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  18. 18
    Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease

    Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease by Saskia N. van der Crabben, Marije P. Hennus, Grant A. McGregor, Deborah Ritter, Sandesh C.S. Nagamani, Owen S. Wells, Magdaléna Harakaľová, Iván K. Chinn, Aaron Alt, Lucie Vondrová, Ron Hochstenbach, Joris M. van Montfrans, Suzanne Terheggen‐Lagro, Stef van Lieshout, Markus J. van Roosmalen, Ivo Renkens, Karen Duran, Isaäc J. Nijman, Wigard P. Kloosterman, Eric A. M. Hennekam, Jordan S. Orange, Peter M. van Hasselt, David A. Wheeler, Jan Paleček, Alan R. Lehmann, Antony W. Oliver, Laurence H. Pearl, Sharon E. Plon, Johanne M. Murray, Gijs van Haaften

    Published 2016
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  19. 19
    Characteristics of de novo structural changes in the human genome

    Characteristics of de novo structural changes in the human genome by Wigard P. Kloosterman, Laurent C. Francioli, Fereydoun Hormozdiari, Tobias Marschall, Jayne Y. Hehir‐Kwa, Abdel Abdellaoui, Eric-Wubbo Lameijer, Matthijs H. Moed, Vyacheslav Koval, Ivo Renkens, Markus J. van Roosmalen, Pascal P. Arp, Lennart C. Karssen, Bradley P. Coe, Robert E. Handsaker, H. Eka D. Suchiman, Edwin Cuppen, Djie Tjwan Thung, Mitch McVey, Michael C. Wendl, André G. Uitterlinden, Cornelia M. van Duijn, Morris A. Swertz, Cisca Wijmenga, Gert‐Jan B. van Ommen, P. Eline Slagboom, Dorret I. Boomsma, Alexander Schönhuth, Evan E. Eichler, Paul I. W. de Bakker, Kai Ye, Victor Guryev

    Published 2015
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  20. 20
    Identification of human D lactate dehydrogenase deficiency

    Identification of human D lactate dehydrogenase deficiency by Glen R. Monroe, Albertien M. van Eerde, Federico Tessadori, Karen Duran, Sanne M. C. Savelberg, Johanna C. van Alfen, Paulien A. Terhal, Saskia N. van der Crabben, Klaske D. Lichtenbelt, Sabine A. Fuchs, Johan Gerrits, Markus J. van Roosmalen, Koen L.I. van Gassen, M. van Aalderen, Bart G.P. Koot, M. van Oostendorp, Marinus Durán, Gepke Visser, Tom J. de Koning, Francesco Calı̀, Paolo Bosco, Karin Geleijns, Monique G.M. de Sain‐van der Velden, Nine Knoers, Jeroen Bakkers, Nanda M. Verhoeven‐Duif, Gijs van Haaften, Judith Jans

    Published 2019
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