Search Results - Markus A. Seeliger

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  1. 1
    Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases**

    Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases** by Mrinal Shekhar, Zachary Smith, Markus A. Seeliger, Pratyush Tiwary

    Published 2022
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  2. 2
    Structural Basis for the Recognition of c-Src by Its Inactivator Csk

    Structural Basis for the Recognition of c-Src by Its Inactivator Csk by Nicholas M. Levinson, Markus A. Seeliger, Philip A. Cole, John Kuriyan

    Published 2008
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  3. 3
    Activation of tyrosine kinases by mutation of the gatekeeper threonine

    Activation of tyrosine kinases by mutation of the gatekeeper threonine by Mohammad Azam, Markus A. Seeliger, Nathanael S. Gray, John Kuriyan, George Q. Daley

    Published 2008
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  4. 4
    A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

    A dynamically coupled allosteric network underlies binding cooperativity in Src kinase by Zachariah H. Foda, Yibing Shan, Eric T. Kim, David E. Shaw, Markus A. Seeliger

    Published 2015
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  5. 5
    c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty

    c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty by Markus A. Seeliger, Bhushan Nagar, Filipp Frank, Xiaoxian Cao, Max Henderson, John Kuriyan

    Published 2007
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  6. 6
    Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms

    Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms by Natalia Jura, Xuewu Zhang, Nicholas Endres, Markus A. Seeliger, Thomas H. Schindler, John Kuriyan

    Published 2011
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  7. 7
    Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites

    Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites by Michael Tong, Jeff Pelton, Michelle L. Gill, Weibing Zhang, Francis Picart, Markus A. Seeliger

    Published 2017
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  8. 8
    Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing

    Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing by Katarzyna M. Sawicka, Markus A. Seeliger, Tagai Musaev, Lauren K. Macri, Richard A.F. Clark

    Published 2015
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  9. 9
    How Does a Drug Molecule Find Its Target Binding Site?

    How Does a Drug Molecule Find Its Target Binding Site? by Yibing Shan, Eric T. Kim, Michael P. Eastwood, Ron O. Dror, Markus A. Seeliger, David E. Shaw

    Published 2011
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  10. 10
    A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

    A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export by Ben Montpetit, N.D. Thomsen, Kara J. Helmke, Markus A. Seeliger, James M. Berger, Karsten Weis

    Published 2011
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  11. 11
    Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

    Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles by George P. Georghiou, Ralph E. Kleiner, Michael J. Pulkoski‐Gross, David R. Liu, Markus A. Seeliger

    Published 2012
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  12. 12
    High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases

    High yield bacterial expression of active c‐Abl and c‐Src tyrosine kinases by Markus A. Seeliger, Matthew A. Young, Max Henderson, Patricia Pellicena, David S. King, Arnold M. Falick, John Kuriyan

    Published 2005
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  13. 13
    A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems

    A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems by Ivan Lebedev, Alice Nemajerová, Zachariah H. Foda, Maja Kornaj, Michael Tong, Ute M. Moll, Markus A. Seeliger

    Published 2016
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  14. 14
    Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase

    Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase by Bhushan Nagar, Oliver Hantschel, Markus A. Seeliger, Jason M. Davies, William I. Weis, Giulio Superti‐Furga, John Kuriyan

    Published 2006
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  15. 15
    Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation

    Three Different Binding Sites of Cks1 Are Required for p27-Ubiquitin Ligation by Danielle Sitry, Markus A. Seeliger, Tun Kiat Ko, Dvora Ganoth, Sadie E Breward, Laura S. Itzhaki, Michele Pagano, Avram Hershko

    Published 2002
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  16. 16
    What Makes a Kinase Promiscuous for Inhibitors?

    What Makes a Kinase Promiscuous for Inhibitors? by Sonya M. Hanson, George P. Georghiou, Manish Thakur, W. Todd Miller, Joshua S. Rest, John D. Chodera, Markus A. Seeliger

    Published 2019
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  17. 17
    Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations

    Equally Potent Inhibition of c-Src and Abl by Compounds that Recognize Inactive Kinase Conformations by Markus A. Seeliger, Pratistha Ranjitkar, Corynn Kasap, Yibing Shan, David E. Shaw, Neil P. Shah, John Kuriyan, Dustin J. Maly

    Published 2009
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  18. 18
    Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

    Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme by Juan Pablo Maianti, G.A. Tan, Amedeo Vetere, A.J. Welsh, Bridget K. Wagner, Markus A. Seeliger, David R. Liu

    Published 2019
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  19. 19
    A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis

    A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis by S. Leah Etheridge, Megan E. Cosgrove, Veena Sangkhae, Lana Corbo, Michelle E. Roh, Markus A. Seeliger, Edward K. L. Chan, Ian S. Hitchcock

    Published 2013
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  20. 20
    A conserved protonation-dependent switch controls drug binding in the Abl kinase

    A conserved protonation-dependent switch controls drug binding in the Abl kinase by Yibing Shan, Markus A. Seeliger, Michael P. Eastwood, Filipp Frank, Huafeng Xu, Morten Ø. Jensen, Ron O. Dror, John Kuriyan, David E. Shaw

    Published 2008
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