Výsledky vyhledávání - Marcel den Hoed

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  1. 1
    Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO

    Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO Autor Marcel den Hoed, Margriet S. Westerterp‐Plantenga, Freek G. Bouwman, Edwin C.M. Mariman, Klaas R. Westerterp

    Vydáno 2009
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  2. 2
    Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis

    Assessing Causality in the Association between Child Adiposity and Physical Activity Levels: A Mendelian Randomization Analysis Autor Rebecca C. Richmond, George Davey Smith, Andy Ness, Marcel den Hoed, George McMahon, Nicholas J. Timpson

    Vydáno 2014
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  3. 3
    Variability in the Heritability of Body Mass Index: A Systematic Review and Meta-Regression

    Variability in the Heritability of Body Mass Index: A Systematic Review and Meta-Regression Autor Cathy E. Elks, Marcel den Hoed, Jing Hua Zhao, Stephen J. Sharp, Nicholas J. Wareham, Ruth J. F. Loos, Ken K. Ong

    Vydáno 2012
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  4. 4
    CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations

    CRISPR-Cas9 induces large structural variants at on-target and off-target sites in vivo that segregate across generations Autor Ida Höijer, Anastasia Emmanouilidou, Rebecka Östlund, Robin van Schendel, Selma Bozorgpana, Marcel Tijsterman, Lars Feuk, Ulf Gyllensten, Marcel den Hoed, Adam Ameur

    Vydáno 2022
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  5. 5
    Heritability of objectively assessed daily physical activity and sedentary behavior

    Heritability of objectively assessed daily physical activity and sedentary behavior Autor Marcel den Hoed, Søren Brage, Wei Zhao, Kate Westgate, Ayrun Nessa, Ulf Ekelund, Tim D. Spector, Nicholas J. Wareham, Ruth J. F. Loos

    Vydáno 2013
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  6. 6
    Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence

    Genetic Susceptibility to Obesity and Related Traits in Childhood and Adolescence Autor Marcel den Hoed, Ulf Ekelund, Søren Brage, Anders Grøntved, Jing Hua Zhao, Stephen J. Sharp, Ken K. Ong, Nicholas J. Wareham, Ruth J. F. Loos

    Vydáno 2010
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  7. 7
    Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity

    Amplification-free long-read sequencing reveals unforeseen CRISPR-Cas9 off-target activity Autor Ida Höijer, Josefin Johansson, Sanna Gudmundsson, Chen-Shan Chin, Ignas Bunikis, Susana Häggqvist, Anastasia Emmanouilidou, Maria Wilbe, Marcel den Hoed, Marie-Louise Bondeson, Lars Feuk, Ulf Gyllensten, Adam Ameur

    Vydáno 2020
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  8. 8
    Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning

    Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning Autor Eugenia Mazzaferro, Endrina Mújica, Hanqing Zhang, Anastasia Emmanouilidou, Anne Jenseit, Bade Evcimen, Christoph Metzendorf, Olga Dethlefsen, Ruth J. F. Loos, Sara G. Vienberg, Anders Larsson, Amin Allalou, Marcel den Hoed

    Vydáno 2025
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  9. 9
    Biological/Genetic Regulation of Physical Activity Level

    Biological/Genetic Regulation of Physical Activity Level Autor J. Timothy Lightfoot, Eco J. C. de Geus, Frank W. Booth, Molly S. Bray, Marcel den Hoed, Jaakko Kaprio, Scott A. Kelly, Daniel Pomp, Michael C. Saul, Martine Thomis, Theodore Garland, Claude Bouchard

    Vydáno 2017
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  10. 10
    Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals

    Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals Autor Tuomas O. Kilpeläinen, Marcel den Hoed, Ken K. Ong, Anders Grøntved, Søren Brage, Early Growth Genetics Consortium, Karen Jameson, Cyrus Cooper, Kay‐Tee Khaw, Ulf Ekelund, Nicholas J Wareham, Ruth J. F. Loos

    Vydáno 2011
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  11. 11
    Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach

    Translating GWAS-identified loci for cardiac rhythm and rate using an in vivo image- and CRISPR/Cas9-based approach Autor Benedikt von der Heyde, Anastasia Emmanouilidou, Eugenia Mazzaferro, Silvia Vicenzi, Ida Höijer, Tiffany Klingström, Sitaf Jumaa, Olga Dethlefsen, Harold Snieder, Eco J. C. de Geus, Adam Ameur, Erik Ingelsson, Amin Allalou, Hannah L. Brooke, Marcel den Hoed

    Vydáno 2020
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  12. 12
    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression

    Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression Autor Katia K. Mattis, Nicole A. J. Krentz, Christoph Metzendorf, Fernando Abaitua, Aliya F Spigelman, Han Sun, Jennifer M. Iklé, Swaraj Thaman, Antje K. Rottner, Austin Bautista, Eugenia Mazzaferro, Marta Perez‐Alcantara, Jocelyn E. Manning Fox, Jason Torres, Agata Wesolowska‐Andersen, Grace Z. Yu, Anubha Mahajan, Anders Larsson, Patrick E. MacDonald, Benjamin Davies, Marcel den Hoed, Anna L. Gloyn

    Vydáno 2023
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  13. 13
    Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance

    Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance Autor Vanessa Pellegrinelli, Sergio Rodríguez‐Cuenca, Christine Rouault, Elizabeth Figueroa‐Juárez, Hanna Marie Schilbert, Sam Virtue, José María Moreno‐Navarrete, Guillaume Bidault, Mari C. Vázquez‐Borrego, Ana Dias, Boas Pucker, M.M. Dale, Mark Campbell, Stefania Carobbio, Yang‐Hua Lin, Michèle Vacca, Judith Aron‐Wisnewsky, Sílvia Mora, Mauro Miguel Masiero, Anastasia Emmanouilidou, Subhankar Mukhopadhyay, Gordon Dougan, Marcel den Hoed, Ruth J. F. Loos, José Manuel Fernández‐Real, Davide Chiarugi, Karine Clément, Antonio Vidal‐Puig

    Vydáno 2022
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  14. 14
    GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification

    GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification Autor Vasiliki Lagou, Longda Jiang, Anna Ulrich, Liudmila Zudina, Karla Sofia Gutiérrez González, Zhanna Balkhiyarova, Alessia Faggian, Jared G. Maina, Shiqian Chen, Petar V. Todorov, Sodbo Sharapov, Alessia David, Letizia Marullo, Reedik Mägi, Roxana‐Maria Rujan, Emma Ahlqvist, Guðmar Þorleifsson, Ηe Gao, Εvangelos Εvangelou, Beben Benyamin, Robert A. Scott, Aaron Isaacs, Wei Zhao, Sara M. Willems, Toby Johnson, Christian Gieger, Harald Grallert, Christa Meisinger, Martina Müller‐Nurasyid, Rona J. Strawbridge, Anuj Goel, Denis Rybin, Eva Albrecht, Anne Jackson, Heather M. Stringham, Ivan R. Corrêa, Eric Farber‐Eger, Valgerður Steinthórsdóttir, André G. Uitterlinden, Patricia B. Munroe, Morris J. Brown, Julian Schmidberger, Oddgeir L. Holmen, Barbara Thorand, Kristian Hveem, Tom Wilsgaard, Karen L. Mohlke, Zhe Wang, Marcel den Hoed, Aleksey Shmeliov, Marcel den Hoed, Ruth J. F. Loos, Wolfgang Kratzer, Mark Martin Haenle, Wolfgang Köenig, Bernhard O. Boehm, Tricia Tan, Alejandra Tomás, Victoria Salem, Inês Barroso, Jaakko Tuomilehto, Michael Boehnke, Jose C. Florez, Anders Hamsten, Hugh Watkins, Inger Njølstad, H.‐Erich Wichmann, Mark J. Caulfield, Kay‐Tee Khaw, Cornelia M. van Duijn, Albert Hofman, Nicholas J. Wareham, Claudia Langenberg, John B. Whitfield, Nicholas G. Martin, Grant W. Montgomery, Chiara Scapoli, Ioanna Tzoulaki, Paul Elliott, Unnur Þorsteinsdóttir, Kāri Stefánsson, Evan L. Brittain, Mark I. McCarthy, Philippe Froguel, Patrick M. Sexton, Denise Wootten, Leif Groop, Josée Dupuis, James B. Meigs, Giuseppe Deganutti, Ayşe Demirkan, Tune H. Pers, Christopher A. Reynolds, Yurii S. Aulchenko, Marika Kaakinen, Ben Jones, Inga Prokopenko, Cornelia M. van Duijn

    Vydáno 2023
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  15. 15
    Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 individuals

    Contribution of common non-synonymous variants in PCSK1 to body mass index variation and risk of obesity: a systematic review and meta-analysis with evidence from up to 331 175 ind... Autor Kevin T. Nead, Ang Li, Mackenzie R. Wehner, Binod Neupane, Stefan Gustafsson, Adam S. Butterworth, James C. Engert, April Davis, Robert A. Hegele, Ruby Miller, Marcel den Hoed, K.-T. Khaw, Tuomas O. Kilpeläinen, Nicholas J. Wareham, Todd L. Edwards, G. Hallmans, Tibor V. Varga, Sharon L. R. Kardia, Jennifer A. Smith, Wei Zhao, Jessica D. Faul, David R. Weir, Jia Mi, Bo Xi, Andrés Sebastián Quinteros, Cyrus Cooper, Avan Aihie Sayer, Anthony James, Anders Grøntved, M. Fornage, Stephen Sidney, Craig L. Hanis, Heather M. Highland, Hans‐Ulrich Häring, Martin Heni, Jessica Lasky‐Su, Scott T. Weiss, Glenn S. Gerhard, C D Still, M Mĕlka, Zdenka Pausová, T. Paus, Struan F.A. Grant, Hákon Hákonarson, R. Arlen Price, Kai Wang, André Scherag, Johannes Hebebrand, Anke Hinney, Paul W. Franks, Timothy M. Frayling, Mark I. McCarthy, Joel N. Hirschhorn, Ruth J. F. Loos, E. Ingelsson, Hertzel C. Gerstein, Salim Yusuf, Joseph Beyene, Sonia S. Anand, Stephen Eyre

    Vydáno 2015
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  16. 16
    Physical activity and sedentary behavior; mechanistic insights and role in disease prevention

    Physical activity and sedentary behavior; mechanistic insights and role in disease prevention Autor Marcel den Hoed, Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Timothy M. Moore, Daiane Hemerich, Marilyn C. Cornelis, Eugenia Mazzaferro, Siacia Broos, Adam Ameur, Stefania Bandinelli, Joshua C. Bis, Michael Boehnke, Claude Bouchard, Daniel I. Chasman, Eco J. C. de Geus, Louise Deldicque, Marcus Dörr, Michele K. Evans, Luigi Ferrucci, Myriam Fornage, Caroline S. Fox, Theodore Garland, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo Lessa Horta, Elina Hyppönen, W. Craig Johnson, Sharon L. R. Kardia, Lambertus A. Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimäki, Loı̈c Le Marchand, Patrik K. E. Magnusson, Nicholas G. Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E. North, Claes Ohlsson, Albertine J. Oldehinkel, Marju Orho‐Melander, Guillaume Paré, Taesung Park, Oluf Pedersen, Brenda W.J.H. Penninx, Tune H. Pers, Ozren Polašek, Inga Prokopenko, Charles N. Rotimi, Nilesh J. Samani, Xueling Sim, George Davey Smith, Harold Snieder, Thorkild I. A. Sørensen, Tim D. Spector, Nicholas J. Timpson, Rob M. van Dam, Nathalie van der Velde, Péter Vollenweider, Henry Völzke, Trudy Voortman, Gérard Waeber, Nicholas J. Wareham, David R. Weir, Erich Wichmann, James F. Wilson, Andrea L. Hevener, Anna Krook, Juleen R. Zierath, Martine Thomis, Ruth J. F. Loos

    Vydáno 2021
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  17. 17
    A genomic approach to therapeutic target validation identifies a glucose-lowering <i>GLP1R</i> variant protective for coronary heart disease

    A genomic approach to therapeutic target validation identifies a glucose-lowering <i>GLP1R</i> variant protective for coronary heart disease Autor Robert A. Scott, Daniel F. Freitag, Li Li, Audrey Y. Chu, Praveen Surendran, Robin Young, Niels Grarup, Alena Stančáková, Yuning Chen, Tibor V. Varga, Hanieh Yaghootkar, Jian’an Luan, Wei Zhao, Sara M. Willems, Jennifer Wessel, Shuai Wang, Nisa M. Maruthur, Kyriaki Michailidou, Ailith Pirie, Sven J. van der Lee, Christopher Gillson, Ali Amin Al Olama, Philippe Amouyel, Larraitz Arriola, Dominique Arveiler, Icíar Avilés-Olmos, Beverley Balkau, Aurelio Barricarte, Inês Barroso, Sara Benlloch Garcia, Joshua C. Bis, Stefan Blankenberg, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Ingrid B. Borecki, Jette Bork‐Jensen, S. Bowden, Carlos Caldas, Muriel Caslake, L. Adrienne Cupples, Carlos Cruchaga, Jacek Czajkowski, Marcel den Hoed, Janet Dunn, Helena Earl, Georg Ehret, Ele Ferrannini, Jean Ferrières, Thomas Foltynie, Ian Ford, Nita G. Forouhi, Francesco Gianfagna, Carlos A. González, Sara Grioni, Louise Hiller, Jan‐Håkan Jansson, Marit E. Jørgensen, J. Wouter Jukema, Rudolf Kaaks, Frank Kee, Nicola D. Kerrison, Timothy J. Key, Jukka Kontto, Zsofia Kote‐Jarai, Aldi T. Kraja, Kari Kuulasmaa, Johanna Kuusisto, Allan Linneberg, Chunyu Liu, Gaëlle Marenne, Karen L. Mohlke, Andrew P. Morris, Kenneth Muir, Martina Müller‐Nurasyid, Patricia B. Munroe, Carmen Navarro, Sune F. Nielsen, Peter M. Nilsson, Børge G. Nordestgaard, Chris J. Packard, Domenico Palli, Salvatore Panico, Gina M. Peloso, Markus Perola, Annette Peters, Christopher Poole, J. Ramón Quirós, Olov Rolandsson, Carlotta Sacerdote, Veikko Salomaa, María‐José Sánchez, Naveed Sattar, Stephen J. Sharp, Rebecca Sims, Nadia Slimani, Jennifer A. Smith, Deborah J. Thompson, Stella Trompet, ­Rosario ­Tumino

    Vydáno 2016
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  18. 18
    Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

    Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults Autor Mariaelisa Graff, Robert A. Scott, Anne E. Justice, Kristin L. Young, Mary F. Feitosa, Llilda Barata, Thomas W. Winkler, Audrey Y. Chu, Anubha Mahajan, David Hadley, Luting Xue, Tsegaselassie Workalemahu, Nancy L. Heard‐Costa, Marcel den Hoed, Tarunveer S. Ahluwalia, Qibin Qi, Julius S. Ngwa, Frida Renström, Lydia Quaye, John D. Eicher, James E. Hayes, Marilyn C. Cornelis, Zoltán Kutalik, Elise Lim, Jian’an Luan, Jennifer E. Huffman, Weihua Zhang, Wei Zhao, Paula J. Griffin, Toomas Haller, Shafqat Ahmad, Pedro Marques‐Vidal, Stephanie A. Bien, Loïc Yengo, Alexander Teumer, Albert V. Smith, Meena Kumari, Marie Neergaard Harder, Johanne Marie Justesen, Marcus E. Kleber, Mette Hollensted, Kurt Lohman, Natalia V. Rivera, John B. Whitfield, Wei Zhao, Heather M. Stringham, Leo‐Pekka Lyytikäinen, Charlotte Huppertz, Gonneke Willemsen, Wouter J. Peyrot, Ying Wu, Kati Kristiansson, Ayşe Demirkan, Myriam Fornage, Maija Hassinen, Lawrence F. Bielak, Gemma Cadby, Toshiko Tanaka, Reedik Mägi, Peter J. van der Most, Anne Jackson, Jennifer L. Bragg‐Gresham, Véronique Vitart, Jonathan Marten, Pau Navarro, Claire Bellis, Dorota Pasko, Åsa Johansson, Søren Snitker, Yu‐Ching Cheng, Joel Eriksson, Unhee Lim, Mette Aadahl, Linda S. Adair, Najaf Amin, Beverley Balkau, Juha Auvinen, John Beilby, Richard N. Bergman, Sven Bergmann, Alain G. Bertoni, John Blangero, Amélie Bonnefond, Lori L. Bonnycastle, Judith B. Borja, Søren Brage, Fabio Busonero, Steven Buyske, Harry Campbell, Peter S. Chines, Francis S. Collins, Tanguy Corre, George Davey Smith, Graciela E. Delgado, Nicole Dueker, Marcus Dörr, Tapani Ebeling, Guðný Eiríksdóttir, Tõnu Esko, Jessica D. Faul

    Vydáno 2017
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  19. 19
    The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits

    The Type 2 Diabetes Knowledge Portal: An open access genetic resource dedicated to type 2 diabetes and related traits Autor Maria C. Costanzo, Marcin von Grotthuss, Jeffrey Massung, Dongkeun Jang, Lizz Caulkins, Ryan Koesterer, Clint Gilbert, Ryan Welch, Parul Kudtarkar, Quy Hoang, Andrew P. Boughton, Preeti Singh, Ying Sun, Marc Duby, Annie Moriondo, Trang Thi Huyen Nguyen, Patrick Smadbeck, Benjamin Alexander, MacKenzie Brandes, Mary Carmichael, Peter Dornbos, Todd J. Green, Kenneth C. Huellas-Bruskiewicz, Yue Ji, Alexandria Kluge, Aoife McMahon, Josep M. Mercader, Oliver Ruebenacker, Sebanti Sengupta, Dylan Spalding, Daniel Taliun, Phil Smith, Melissa K. Thomas, Beena Akolkar, M. Julia Brosnan, Andriy Cherkas, Audrey Y. Chu, Eric B. Fauman, Caroline S. Fox, Tania N. Kamphaus, Melissa Miller, Lynette Nguyen, Afshin Parsa, Dermot F. Reilly, Hartmut Ruetten, David Wholley, Norann A. Zaghloul, Gonçalo R. Abecasis, David Altshuler, Thomas Keane, Mark I. McCarthy, Kyle J. Gaulton, José C. Florez, Michael Boehnke, Noël P. Burtt, Jason Flannick, Gonçalo R. Abecasis, Beena Akolkar, Benjamin Alexander, Nicholette D. Allred, David Altshuler, Jennifer E. Below, Richard N. Bergman, Joline W. J. Beulens, John Blangero, Michael Boehnke, Krister Bokvist, Erwin Böttinger, Andrew P. Boughton, Donald W. Bowden, M. Julia Brosnan, Christopher D. Brown, Kenneth Bruskiewicz, Noël P. Burtt, Mary Carmichael, Lizz Caulkins, Inês Cebola, John C. Chambers, Yii‐Der Ida Chen, Andriy Cherkas, Audrey Y. Chu, Christopher Clark, Melina Claussnitzer, Maria C. Costanzo, Nancy J. Cox, Marcel den Hoed, Duc Dong, Marc Duby, Ravindranath Duggirala, Josée Dupuis, Petra J. M. Elders, J Engreitz, Eric B. Fauman, Jorge Ferrer, Jason Flannick, Paul Flicek, Matthew Flickinger, José C. Florez, Caroline S. Fox, Timothy M. Frayling

    Vydáno 2023
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  20. 20
    Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders

    Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders Autor Marcel den Hoed, Mark Eijgelsheim, Tõnu Esko, Bianca J.J.M. Brundel, David S. Peal, David M. Evans, Ilja M. Nolte, Ayellet V. Segrè, Hilma Hólm, Robert E. Handsaker, Harm-Jan Westra, Toby Johnson, Aaron Isaacs, Jian Yang, Alicia Lundby, Jing Zhao, Young Jin Kim, Min Jin Go, Peter Almgren, Murielle Bochud, Gabrielle Boucher, Marilyn C. Cornelis, Daníel F. Guðbjartsson, David Hadley, Pim van der Harst, Caroline Hayward, Martin den Heijer, Wilmar Igl, Anne Jackson, Zoltán Kutalik, Jian’an Luan, John P. Kemp, Kati Kristiansson, Claes Ladenvall, Mattias Lorentzon, May E. Montasser, Omer T. Njajou, Paul F. O’Reilly, Sandosh Padmanabhan, Beaté St Pourcain, Tuomo Rankinen, Perttu Salo, Toshiko Tanaka, Nicholas J. Timpson, Véronique Vitart, Lindsay L. Waite, William Wheeler, Weihua Zhang, Harmen H. M. Draisma, Mary F. Feitosa, Kathleen F. Kerr, Penelope A. Lind, Evelin Mihailov, N. Charlotte Onland‐Moret, Ci Song, Michael N. Weedon, Weijia Xie, Loïc Yengo, Devin Absher, Christine M. Albert, Álvaro Alonso, Dan E. Arking, Paul I. W. de Bakker, Beverley Balkau, Cristina Barlassina, Paola Benaglio, Joshua C. Bis, Nabila Bouatia‐Naji, Søren Brage, Stephen J. Chanock, Peter S. Chines, Mina K. Chung, Dawood Darbar, Christian Dina, Marcus Dörr, Paul Elliott, Stephan B. Felix, Krista Fischer, Christian Fuchsberger, Eco J. C. de Geus, Philippe Goyette, Vilmundur Guðnason, Tamara B. Harris, Anna‐Liisa Hartikainen, Aki S. Havulinna, Susan R. Heckbert, Andrew A. Hicks, Albert Hofman, Suzanne Holewijn, Femke Hoogstra‐Berends, Jouke‐Jan Hottenga, Majken K. Jensen, Åsa Johansson, Juhani Junttila, Stefan Kääb, Bart Kanon, Shamika Ketkar, Kay‐Tee Khaw, Joshua W. Knowles, Angrad S Kooner

    Vydáno 2013
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