Hakutulokset - Makoto Hirata

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  1. 1
    Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development

    Transcriptional Induction of ADAMTS5 Protein by Nuclear Factor-κB (NF-κB) Family Member RelA/p65 in Chondrocytes during Osteoarthritis Development Tekijä Hiroshi Kobayashi, Makoto Hirata, Taku Saito, Shozo Itoh, Ung‐il Chung, Hiroshi Kawaguchi

    Julkaistu 2013
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  2. 2
    Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53

    Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53 Tekijä Takafumi Miyamoto, Paulisally Hau Yi Lo, Naomi Saichi, Koji Ueda, Makoto Hirata, Chizu Tanikawa, Koichi Matsuda

    Julkaistu 2017
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  3. 3
    Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome

    Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome Tekijä Atsunori Higashino, Ryuichi Sakate, Yosuke Kameoka, Ichiro Takahashi, Makoto Hirata, Reiko Tanuma, Tohru Masui, Yasuhiro Yasutomi, Naoki Osada

    Julkaistu 2012
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  4. 4
    GSK-3β Controls Osteogenesis through Regulating Runx2 Activity

    GSK-3β Controls Osteogenesis through Regulating Runx2 Activity Tekijä Fumitaka Kugimiya, Hiroshi Kawaguchi, Shinsuke Ohba, Naohiro Kawamura, Makoto Hirata, Hirotaka Chikuda, Yoshiaki Azuma, James R. Woodgett, Kozo Nakamura, Ung‐il Chung

    Julkaistu 2007
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  5. 5
    Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development

    Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development Tekijä Yoko Hosaka, Taku Saito, Shurei Sugita, Tomohiro Hikata, Hiroshi Kobayashi, Atsushi Fukai, Yuki Taniguchi, Makoto Hirata, Haruhiko Akiyama, Ung‐il Chung, Hiroshi Kawaguchi

    Julkaistu 2013
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  6. 6
    GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

    GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation Tekijä Shozo Itoh, Taku Saito, Makoto Hirata, M. Ushita, Toshiyuki Ikeda, James R. Woodgett, Hana Algül, Roland M. Schmid, Ung‐il Chung, Hiroshi Kawaguchi

    Julkaistu 2012
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  7. 7
    GWAS of five gynecologic diseases and cross-trait analysis in Japanese

    GWAS of five gynecologic diseases and cross-trait analysis in Japanese Tekijä Tatsuo Masuda, Siew‐Kee Low, Masato Akiyama, Makoto Hirata, Yutaka Ueda, Koichi Matsuda, Tadashi Kimura, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani, Yukinori Okada

    Julkaistu 2019
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  8. 8
    A novel disease-modifying osteoarthritis drug candidate targeting Runx1

    A novel disease-modifying osteoarthritis drug candidate targeting Runx1 Tekijä Fumiko Yano, Hironori Hojo, Shinsuke Ohba, Atsushi Fukai, Yoko Hosaka, Toshiyuki Ikeda, Taku Saito, Makoto Hirata, Hirotaka Chikuda, Tsuyoshi Takato, Hiroshi Kawaguchi, Ung‐il Chung

    Julkaistu 2012
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  9. 9
    Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases

    Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases Tekijä Masahiro Kanai, Masato Akiyama, Atsushi Takahashi, Nana Matoba, Yukihide Momozawa, Masashi Ikeda, Nakao Iwata, Shiro Ikegawa, Makoto Hirata, Koichi Matsuda, Michiaki Kubo, Yukinori Okada, Yoichiro Kamatani

    Julkaistu 2018
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  10. 10
    C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2

    C/EBPβ Promotes Transition from Proliferation to Hypertrophic Differentiation of Chondrocytes through Transactivation of p57Kip2 Tekijä Makoto Hirata, Fumitaka Kugimiya, Atsushi Fukai, Shinsuke Ohba, Naohiro Kawamura, Toru Ogasawara, Yosuke Kawasaki, Taku Saito, Fumiko Yano, Toshiyuki Ikeda, Kozo Nakamura, Ung‐il Chung, Hiroshi Kawaguchi

    Julkaistu 2009
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  11. 11
    Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 Controls

    Germline Pathogenic Variants in 7636 Japanese Patients With Prostate Cancer and 12 366 Controls Tekijä Yukihide Momozawa, Yusuke Iwasaki, Makoto Hirata, Xiaoxi Liu, Yoichiro Kamatani, Atsushi Takahashi, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami, Koichi Matsuda, Hidewaki Nakagawa, Amanda B. Spurdle, Michiaki Kubo

    Julkaistu 2019
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  12. 12
    Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes

    Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes Tekijä Keijiro Mizukami, Yusuke Iwasaki, Eiryo Kawakami, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Mikiko Endo, Kokichi Sugano, Teruhiko Yoshida, Yoshinori Murakami, Hidewaki Nakagawa, Amanda B. Spurdle, Yukihide Momozawa

    Julkaistu 2020
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  13. 13
    Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype

    Mesenchymal Tumors Can Derive from Ng2/Cspg4-Expressing Pericytes with β-Catenin Modulating the Neoplastic Phenotype Tekijä Shingo Sato, Yuning J. Tang, Qingxia Wei, Makoto Hirata, Angela Weng, Ilkyu Han, Atsushi Okawa, Shu Takeda, Heather Whetstone, Puvindran Nadesan, David G. Kirsch, Jay S. Wunder, Benjamin A. Alman

    Julkaistu 2016
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  14. 14
    Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan

    Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan Tekijä Saori Sakaue, Masahiro Kanai, Juha Karjalainen, Masato Akiyama, Mitja Kurki, Nana Matoba, Atsushi Takahashi, Makoto Hirata, Michiaki Kubo, Koichi Matsuda, Yoshinori Murakami, Mark J. Daly, Yoichiro Kamatani, Yukinori Okada

    Julkaistu 2020
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  15. 15
    Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls

    Germline pathogenic variants of 11 breast cancer genes in 7,051 Japanese patients and 11,241 controls Tekijä Yukihide Momozawa, Yusuke Iwasaki, Michael T. Parsons, Yoichiro Kamatani, Atsushi Takahashi, Chieko Tamura, Toyomasa Katagiri, Teruhiko Yoshida, Seigo Nakamura, Kokichi Sugano, Yoshio Miki, Makoto Hirata, Koichi Matsuda, Amanda B. Spurdle, Michiaki Kubo

    Julkaistu 2018
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  16. 16
    Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes

    Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes Tekijä Hiroshi Kobayashi, Song Ho Chang, Daisuke Mori, Shozo Itoh, Makoto Hirata, Yoko Hosaka, Yuki Taniguchi, Keita Okada, Yoshifumi Mori, Fumiko Yano, Ung‐il Chung, Haruhiko Akiyama, Hiroshi Kawaguchi, Sakae Tanaka, Taku Saito

    Julkaistu 2016
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  17. 17
    GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation

    GWAS of mosaic loss of chromosome Y highlights genetic effects on blood cell differentiation Tekijä Chikashi Terao, Yukihide Momozawa, Kazuyoshi Ishigaki, Eiryo Kawakami, Masato Akiyama, Po‐Ru Loh, Giulio Genovese, Hiroki Sugishita, Tazro Ohta, Makoto Hirata, John R. B. Perry, Koichi Matsuda, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani

    Julkaistu 2019
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  18. 18
    C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

    C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes Tekijä Makoto Hirata, Fumitaka Kugimiya, Atsushi Fukai, Taku Saito, Fumiko Yano, Toshiyuki Ikeda, Akihiko Mabuchi, Bishwa R. Sapkota, Toru Akune, Nao Nishida, Noriko Yoshimura, Takumi Nakagawa, Katsushi Tokunaga, Kozo Nakamura, Ung‐il Chung, Hiroshi Kawaguchi

    Julkaistu 2011
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  19. 19
    Elucidating the genetic architecture of reproductive ageing in the Japanese population

    Elucidating the genetic architecture of reproductive ageing in the Japanese population Tekijä Momoko Horikoshi, Felix R. Day, Masato Akiyama, Makoto Hirata, Yoichiro Kamatani, Koichi Matsuda, Kazuyoshi Ishigaki, Masahiro Kanai, Hollis Wright, Carlos A. Toro, Sergio R. Ojeda, Alejandro Lomniczi, Michiaki Kubo, Ken K. Ong, John R. B. Perry

    Julkaistu 2018
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  20. 20
    Introducing AI to the molecular tumor board: one direction toward the establishment of precision medicine using large-scale cancer clinical and biological information

    Introducing AI to the molecular tumor board: one direction toward the establishment of precision medicine using large-scale cancer clinical and biological information Tekijä Ryuji Hamamoto, Takafumi Koyama, Nobuji Kouno, Tomohiro Yasuda, Shuntaro Yui, Kazuki Sudo, Makoto Hirata, Kuniko Sunami, Takashi Kubo, Ken Takasawa, Satoshi Takahashi, Hidenori Machino, Kazuma Kobayashi, Ken Asada, Masaaki Komatsu, Syuzo Kaneko, Yasushi Yatabe, Noboru Yamamoto

    Julkaistu 2022
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