检索结果 - Macartney, Thomas

Identification and characterization of MUS81 point mutations that abolish interaction with the SLX4 scaffold protein 由 Nair, Nidhi, Castor, Dennis, Macartney, Thomas, Rouse, John

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Interleukin-1 and TRAF6-dependent activation of TAK1 in the absence of TAB2 and TAB3 由 Zhang, Jiazhen, Macartney, Thomas, Peggie, Mark, Cohen, Philip

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IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling 由 Dunbar, Karen, Macartney, Thomas J, Sapkota, Gopal P

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An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins 由 Macartney, Thomas J, Sapkota, Gopal P, Fulcher, Luke J

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USP11 augments TGFβ signalling by deubiquitylating ALK5 由 Al-Salihi, Mazin A., Herhaus, Lina, Macartney, Thomas, Sapkota, Gopal P.

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OTUB1 enhances TGFβ signalling by inhibiting the ubiquitylation and degradation of active SMAD2/3 由 Herhaus, Lina, Al-Salihi, Mazin, Macartney, Thomas, Weidlich, Simone, Sapkota, Gopal P.

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Critical role of the SPAK protein kinase CCT domain in controlling blood pressure 由 Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M., Alessi, Dario R.

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Rapid generation of endogenously driven transcriptional reporters in cells through CRISPR/Cas9 由 Rojas-Fernandez, Alejandro, Herhaus, Lina, Macartney, Thomas, Lachaud, Christophe, Hay, Ronald T., Sapkota, Gopal P.

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Targeting endogenous proteins for degradation through the affinity-directed protein missile system 由 Fulcher, Luke J., Hutchinson, Luke D., Macartney, Thomas J., Turnbull, Craig, Sapkota, Gopal P.

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Reconstitution of human CMG helicase ubiquitylation by CUL2(LRR1) and multiple E2 enzymes 由 Le, Thanh Thi, Ainsworth, Johanna, Polo Rivera, Cristian, Macartney, Thomas, Labib, Karim P.M.

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Structural insights into the activation of MST3 by MO25 由 Mehellou, Youcef, Alessi, Dario R., Macartney, Thomas J., Szklarz, Marta, Knapp, Stefan, Elkins, Jonathan M.

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An affinity-directed protein missile system for targeted proteolysis 由 Fulcher, Luke J., Macartney, Thomas, Bozatzi, Polyxeni, Hornberger, Annika, Rojas-Fernandez, Alejandro, Sapkota, Gopal P.

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FAM83F regulates canonical Wnt signalling through an interaction with CK1α 由 Dunbar, Karen, Jones, Rebecca A, Dingwell, Kevin, Macartney, Thomas J, Smith, James C, Sapkota, Gopal P

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Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks 由 Malik, Nazma, Macartney, Thomas, Hornberger, Annika, Anderson, Karen E., Tovell, Hannah, Prescott, Alan R., Alessi, Dario R.

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Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling 由 Vogt, Janis, Dingwell, Kevin S., Herhaus, Lina, Gourlay, Robert, Macartney, Thomas, Campbell, David, Smith, James C., Sapkota, Gopal P.

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Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader 由 Tovell, Hannah, Testa, Andrea, Maniaci, Chiara, Zhou, Houjiang, Prescott, Alan R, Macartney, Thomas, Ciulli, Alessio, Alessi, Dario R

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Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System 由 Röth, Sascha, Macartney, Thomas J., Konopacka, Agnieszka, Chan, Kwok-Ho, Zhou, Houjiang, Queisser, Markus A., Sapkota, Gopal P.

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USP45 deubiquitylase controls ERCC1–XPF endonuclease-mediated DNA damage responses 由 Perez-Oliva, Ana B, Lachaud, Christophe, Szyniarowski, Piotr, Muñoz, Ivan, Macartney, Thomas, Hickson, Ian, Rouse, John, Alessi, Dario R

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The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters 由 delos Heros, Paola, Alessi, Dario R., Gourlay, Robert, Campbell, David G., Deak, Maria, Macartney, Thomas J., Kahle, Kristopher T., Zhang, Jinwei

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The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt intera... 由 Ohta, Akihito, Schumacher, Frances-Rose, Mehellou, Youcef, Johnson, Clare, Knebel, Axel, Macartney, Thomas J., Wood, Nicola T., Alessi, Dario R., Kurz, Thimo

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