检索结果 - M. Sexton

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  1. 1
    Allosteric Modulation of Muscarinic Acetylcholine Receptors

    Allosteric Modulation of Muscarinic Acetylcholine Receptors 由 Karen J. Gregory, Patrick M. Sexton, Arthur Christopoulos

    出版 2007
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  2. 2
    Bridging the gap: bitopic ligands of G-protein-coupled receptors

    Bridging the gap: bitopic ligands of G-protein-coupled receptors 由 J. Robert Lane, Patrick M. Sexton, Arthur Christopoulos

    出版 2012
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  3. 3
    Novel Allosteric Modulators of G Protein-coupled Receptors

    Novel Allosteric Modulators of G Protein-coupled Receptors 由 Patrick R. Gentry, Patrick M. Sexton, Arthur Christopoulos

    出版 2015
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  4. 4
    Engendering biased signalling from the calcium‐sensing receptor for the pharmacotherapy of diverse disorders

    Engendering biased signalling from the calcium‐sensing receptor for the pharmacotherapy of diverse disorders 由 Katie Leach, Patrick M. Sexton, Arthur Christopoulos, Arthur D. Conigrave

    出版 2013
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  5. 5
    Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM

    Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM 由 Sarah Piper, Rachel M. Johnson, Denise Wootten, Patrick M. Sexton

    出版 2022
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  6. 6
    Chicken osteoclasts do not possess calcitonin receptors

    Chicken osteoclasts do not possess calcitonin receptors 由 Geoffrey C. Nicholson, Jane M. Moseley, Patrick M. Sexton, T John Martin

    出版 1987
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  7. 7
    Endogenous Allosteric Modulators of G Protein–Coupled Receptors

    Endogenous Allosteric Modulators of G Protein–Coupled Receptors 由 Emma T. van der Westhuizen, Céline Valant, Patrick M. Sexton, Arthur Christopoulos

    出版 2015
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  8. 8
    Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

    Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations 由 Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton

    出版 2013
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  9. 9
    Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor

    Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor 由 Vindhya Nawaratne, Katie Leach, Christian C. Felder, Patrick M. Sexton, Arthur Christopoulos

    出版 2010
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  10. 10
    Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

    Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors 由 Wessel A. C. Burger, Patrick M. Sexton, Arthur Christopoulos, David M. Thal

    出版 2018
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  11. 11
    Cryo-EM as a tool for illuminating activation mechanisms of human class A orphan GPCRs

    Cryo-EM as a tool for illuminating activation mechanisms of human class A orphan GPCRs 由 Isabella C. Russell, Dongju Lee, Denise Wootten, Patrick M. Sexton, Fabian Bumbak

    出版 2025
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  12. 12
    Biased Agonism and Biased Allosteric Modulation at the CB<sub>1</sub>Cannabinoid Receptor

    Biased Agonism and Biased Allosteric Modulation at the CB<sub>1</sub>Cannabinoid Receptor 由 Elham Khajehali, Daniel T. Malone, Michelle Glass, Patrick M. Sexton, Arthur Christopoulos, Katie Leach

    出版 2015
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  13. 13
    Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

    Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1 由 Marlies V. Hager, Lachlan Clydesdale, Samuel H. Gellman, Patrick M. Sexton, Denise Wootten

    出版 2017
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  14. 14
    A kinetic view of GPCR allostery and biased agonism

    A kinetic view of GPCR allostery and biased agonism 由 J. Robert Lane, Lauren T. May, Robert G. Parton, Patrick M. Sexton, Arthur Christopoulos

    出版 2017
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  15. 15
    G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

    G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus 由 Darren Riddy, Philippe Delerive, Roger J. Summers, Patrick M. Sexton, Christopher J. Langmead

    出版 2017
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  16. 16
    Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Mechanisms of signalling and biased agonism in G protein-coupled receptors 由 Denise Wootten, Arthur Christopoulos, Maria Martí-Solano, M. Madan Babu, Patrick M. Sexton

    出版 2018
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  17. 17
    Impact of species variability and ‘probe‐dependence’ on the detection and<i>in vivo</i>validation of allosteric modulation at the M<sub>4</sub>muscarinic acetylcholine receptor

    Impact of species variability and ‘probe‐dependence’ on the detection and<i>in vivo</i>validation of allosteric modulation at the M<sub>4</sub>muscarinic acetylcholine receptor... 由 Suraya Suratman, Katie Leach, Patrick M. Sexton, Christian C. Felder, RE Loiacono, Arthur Christopoulos

    出版 2010
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  18. 18
    Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

    Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor 由 Anna Davey, Katie Leach, Céline Valant, Arthur D. Conigrave, Patrick M. Sexton, Arthur Christopoulos

    出版 2011
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  19. 19
    Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation

    Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation 由 Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton

    出版 2011
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  20. 20
    Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

    Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias 由 Karen J. Gregory, Nathan E. Hall, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos

    出版 2010
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