Resultats de la cerca - M. Sexton

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  1. 1
    Allosteric Modulation of Muscarinic Acetylcholine Receptors

    Allosteric Modulation of Muscarinic Acetylcholine Receptors per Karen J. Gregory, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2007
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  2. 2
    Bridging the gap: bitopic ligands of G-protein-coupled receptors

    Bridging the gap: bitopic ligands of G-protein-coupled receptors per J. Robert Lane, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2012
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  3. 3
    Novel Allosteric Modulators of G Protein-coupled Receptors

    Novel Allosteric Modulators of G Protein-coupled Receptors per Patrick R. Gentry, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2015
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  4. 4
    Engendering biased signalling from the calcium‐sensing receptor for the pharmacotherapy of diverse disorders

    Engendering biased signalling from the calcium‐sensing receptor for the pharmacotherapy of diverse disorders per Katie Leach, Patrick M. Sexton, Arthur Christopoulos, Arthur D. Conigrave

    Publicat 2013
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  5. 5
    Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM

    Membranes under the Magnetic Lens: A Dive into the Diverse World of Membrane Protein Structures Using Cryo-EM per Sarah Piper, Rachel M. Johnson, Denise Wootten, Patrick M. Sexton

    Publicat 2022
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  6. 6
    Chicken osteoclasts do not possess calcitonin receptors

    Chicken osteoclasts do not possess calcitonin receptors per Geoffrey C. Nicholson, Jane M. Moseley, Patrick M. Sexton, T John Martin

    Publicat 1987
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  7. 7
    Endogenous Allosteric Modulators of G Protein–Coupled Receptors

    Endogenous Allosteric Modulators of G Protein–Coupled Receptors per Emma T. van der Westhuizen, Céline Valant, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2015
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  8. 8
    Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

    Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations per Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton

    Publicat 2013
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  9. 9
    Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor

    Structural Determinants of Allosteric Agonism and Modulation at the M4 Muscarinic Acetylcholine Receptor per Vindhya Nawaratne, Katie Leach, Christian C. Felder, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2010
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  10. 10
    Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors

    Toward an understanding of the structural basis of allostery in muscarinic acetylcholine receptors per Wessel A. C. Burger, Patrick M. Sexton, Arthur Christopoulos, David M. Thal

    Publicat 2018
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  11. 11
    Cryo-EM as a tool for illuminating activation mechanisms of human class A orphan GPCRs

    Cryo-EM as a tool for illuminating activation mechanisms of human class A orphan GPCRs per Isabella C. Russell, Dongju Lee, Denise Wootten, Patrick M. Sexton, Fabian Bumbak

    Publicat 2025
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  12. 12
    Biased Agonism and Biased Allosteric Modulation at the CB<sub>1</sub>Cannabinoid Receptor

    Biased Agonism and Biased Allosteric Modulation at the CB<sub>1</sub>Cannabinoid Receptor per Elham Khajehali, Daniel T. Malone, Michelle Glass, Patrick M. Sexton, Arthur Christopoulos, Katie Leach

    Publicat 2015
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  13. 13
    Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1

    Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1 per Marlies V. Hager, Lachlan Clydesdale, Samuel H. Gellman, Patrick M. Sexton, Denise Wootten

    Publicat 2017
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  14. 14
    A kinetic view of GPCR allostery and biased agonism

    A kinetic view of GPCR allostery and biased agonism per J. Robert Lane, Lauren T. May, Robert G. Parton, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2017
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  15. 15
    G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus

    G Protein–Coupled Receptors Targeting Insulin Resistance, Obesity, and Type 2 Diabetes Mellitus per Darren Riddy, Philippe Delerive, Roger J. Summers, Patrick M. Sexton, Christopher J. Langmead

    Publicat 2017
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  16. 16
    Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Mechanisms of signalling and biased agonism in G protein-coupled receptors per Denise Wootten, Arthur Christopoulos, Maria Martí-Solano, M. Madan Babu, Patrick M. Sexton

    Publicat 2018
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  17. 17
    Impact of species variability and ‘probe‐dependence’ on the detection and<i>in vivo</i>validation of allosteric modulation at the M<sub>4</sub>muscarinic acetylcholine receptor

    Impact of species variability and ‘probe‐dependence’ on the detection and<i>in vivo</i>validation of allosteric modulation at the M<sub>4</sub>muscarinic acetylcholine receptor... per Suraya Suratman, Katie Leach, Patrick M. Sexton, Christian C. Felder, RE Loiacono, Arthur Christopoulos

    Publicat 2010
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  18. 18
    Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor

    Positive and Negative Allosteric Modulators Promote Biased Signaling at the Calcium-Sensing Receptor per Anna Davey, Katie Leach, Céline Valant, Arthur D. Conigrave, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2011
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  19. 19
    Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation

    Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation per Cassandra Koole, Denise Wootten, John Simms, Laurence J. Miller, Arthur Christopoulos, Patrick M. Sexton

    Publicat 2011
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  20. 20
    Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias

    Identification of Orthosteric and Allosteric Site Mutations in M2 Muscarinic Acetylcholine Receptors That Contribute to Ligand-selective Signaling Bias per Karen J. Gregory, Nathan E. Hall, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos

    Publicat 2010
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