Søgeresultater - Lothar Gremer

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  1. 1
    A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family

    A BAR domain-mediated autoinhibitory mechanism for RhoGAPs of the GRAF family af Alexander Eberth, Richard Lundmark, Lothar Gremer, Radovan Dvorský, Katja T. Koessmeier, Harvey T. McMahon, Mohammad Reza Ahmadian

    Udgivet 2008
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  2. 2
    β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor

    β-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor af Ewa A. Mirecka, Sophie Feuerstein, Lothar Gremer, Gunnar F. Schröder, Matthias Stoldt, Dieter Willbold, Wolfgang Hoyer

    Udgivet 2016
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  3. 3
    Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (GEFs) p115, PDZ-RhoGEF (PRG), and Leukemia-associated RhoGEF (LARG)

    Mechanistic Insights into Specificity, Activity, and Regulatory Elements of the Regulator of G-protein Signaling (RGS)-containing Rho-specific Guanine Nucleotide Exchange Factors (... af Mamta Jaiswal, Lothar Gremer, Radovan Dvorský, Lars Christian Haeusler, Ion Cristian Cirstea, Katharina Uhlenbrock, Mohammad Reza Ahmadian

    Udgivet 2011
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  4. 4
    Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth

    Opposed Effects of Dityrosine Formation in Soluble and Aggregated α-Synuclein on Fibril Growth af Michael M. Wördehoff, Hamed Shaykhalishahi, Luca Groß, Lothar Gremer, Matthias Stoldt, Alexander K. Buell, Dieter Willbold, Wolfgang Hoyer

    Udgivet 2017
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  5. 5
    The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction

    The C2 domain of SynGAP is essential for stimulation of the Rap GTPase reaction af Vladimir Peña, Michael Hothorn, Alexander Eberth, Nikolai Kaschau, Annabel Parret, Lothar Gremer, Fabien Bonneau, Mohammad Reza Ahmadian, Klaus Scheffzek

    Udgivet 2008
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  6. 6
    Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders

    Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders af Lothar Gremer, Torsten Merbitz-Zahradnik, Radovan Dvorský, Ion Cristian Cirstea, Christian P. Kratz, Martin Zenker, Alfred Wittinghofer, Mohammad Reza Ahmadian

    Udgivet 2010
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  7. 7
    Synthesis of the Rheb and K‐Ras4B GTPases

    Synthesis of the Rheb and K‐Ras4B GTPases af Yong‐Xiang Chen, Sebastian Koch, Katharina Uhlenbrock, Katrin Weise, Debapratim Das, Lothar Gremer, Luc Brunsveld, Alfred Wittinghofer, Roland Winter, Gemma Triola, Herbert Waldmann

    Udgivet 2010
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  8. 8
    Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

    Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy af Christine Röder, Nicola Vettore, Lena N. Mangels, Lothar Gremer, Raimond B. G. Ravelli, Dieter Willbold, Wolfgang Hoyer, Alexander K. Buell, Gunnar F. Schröder

    Udgivet 2019
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  9. 9
    Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils

    Cryo-EM structure of islet amyloid polypeptide fibrils reveals similarities with amyloid-β fibrils af Christine Röder, Tatsiana Kupreichyk, Lothar Gremer, Luisa U. Schäfer, Karunakar R. Pothula, Raimond B. G. Ravelli, Dieter Willbold, Wolfgang Hoyer, Gunnar F. Schröder

    Udgivet 2020
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  10. 10
    Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

    Fibril structure of amyloid-β(1–42) by cryo–electron microscopy af Lothar Gremer, Daniel Schölzel, C. Schenk, Elke Reinartz, Jörg Labahn, Raimond B. G. Ravelli, Markus Tusche, Carmen López‐Iglesias, Wolfgang Hoyer, Henrike Heise, Dieter Willbold, Gunnar F. Schröder

    Udgivet 2017
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  11. 11
    Rho-kinase: regulation, (dys)function, and inhibition

    Rho-kinase: regulation, (dys)function, and inhibition af Ehsan Amin, Badri N. Dubey, Si-Cai Zhang, Lothar Gremer, Radovan Dvorský, Jens M. Moll, Mohamed S. Taha, Luitgard Nagel‐Steger, Roland P. Piekorz, Avril V. Somlyo, Mohammad Reza Ahmadian

    Udgivet 2013
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  12. 12
    The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology

    The Aβ oligomer eliminating D-enantiomeric peptide RD2 improves cognition without changing plaque pathology af Thomas van Groen, Sarah Schemmert, Oleksandr Brener, Lothar Gremer, Tamar Ziehm, Markus Tusche, Luitgard Nagel‐Steger, Inga Kadish, Elena Schartmann, Anne Elfgen, Dagmar Jürgens, Antje Willuweit, Janine Kutzsche, Dieter Willbold

    Udgivet 2017
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  13. 13
    Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease

    Preclinical Pharmacokinetic Studies of the Tritium Labelled D-Enantiomeric Peptide D3 Developed for the Treatment of Alzheimer´s Disease af Nan Jiang, Leonie H. E. Leithold, Julia Post, Tamar Ziehm, Jörg Mauler, Lothar Gremer, Markus Cremer, Elena Schartmann, N. Jon Shah, Janine Kutzsche, Karl‐Josef Langen, Jörg Breitkreutz, Dieter Willbold, Antje Willuweit

    Udgivet 2015
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  14. 14
    Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease

    Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer’s disease af Mara Zielinski, Fernanda S. Peralta Reyes, Lothar Gremer, Sarah Schemmert, Benedikt Frieg, Luisa U. Schäfer, Antje Willuweit, L Donner, Margitta Elvers, Lars Nilsson, Stina Syvänen, Dag Sehlin, Martin Ingelsson, Dieter Willbold, Gunnar F. Schröder

    Udgivet 2023
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  15. 15
    Origin of metastable oligomers and their effects on amyloid fibril self-assembly

    Origin of metastable oligomers and their effects on amyloid fibril self-assembly af Filip Hasecke, Tatiana Miti, Carlos J. Pérez-Rivera, Jeremy Barton, Daniel Schölzel, Lothar Gremer, Clara S. R. Grüning, Garrett Matthews, Georg Meisl, Tuomas P. J. Knowles, Dieter Willbold, Philipp Neudecker, Henrike Heise, Ghanim Ullah, Wolfgang Hoyer, Martin Muschol

    Udgivet 2018
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  16. 16
    QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers

    QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers af Oleksandr Brener, Tina Dunkelmann, Lothar Gremer, Thomas van Groen, Ewa A. Mirecka, Inga Kadish, Antje Willuweit, Janine Kutzsche, Dagmar Jürgens, Stephan Rudolph, Markus Tusche, Patrick Bongen, Jörg Pietruszka, Filipp Oesterhelt, Karl‐Josef Langen, Hans‐Ulrich Demuth, Arnold Janssen, Wolfgang Hoyer, Susanne Aileen Funke, Luitgard Nagel‐Steger, Dieter Willbold

    Udgivet 2015
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  17. 17
    A restricted spectrum of NRAS mutations causes Noonan syndrome

    A restricted spectrum of NRAS mutations causes Noonan syndrome af Ion Cristian Cirstea, Kerstin Kutsche, Radovan Dvorský, Lothar Gremer, Claudio Carta, Denise Horn, Amy E. Roberts, Francesca Romana Lepri, Torsten Merbitz-Zahradnik, Rainer König, Christian P. Kratz, Francesca Pantaleoni, Maria Lisa Dentici, Victoria A. Joshi, Raju Kucherlapati, Laura Mazzanti, Stefan Mundlos, Michael A. Patton, Margherita Silengo, Cesare Rossi, Giuseppe Zampino, Cristina Digilio, Liborio Stuppia, E Seemanová, L Pennacchio, Bruce D. Gelb, Bruno Dallapiccola, Alfred Wittinghofer, Mohammad Reza Ahmadian, Marco Tartaglia, Martin Zenker

    Udgivet 2009
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