检索结果 - Lewis, Annabelle

Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines 由 Davis, Hayley, Lewis, Annabelle, Behrens, Axel, Tomlinson, Ian

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Tandem Repeat Hypothesis in Imprinting: Deletion of a Conserved Direct Repeat Element Upstream of H19 Has No Effect on Imprinting in the Igf2-H19 Region 由 Lewis, Annabelle, Mitsuya, Kohzoh, Constancia, Miguel, Reik, Wolf

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FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development 由 Davis, Hayley, Lewis, Annabelle, Spencer-Dene, Bradley, Tateossian, Hilda, Stamp, Gordon, Behrens, Axel, Tomlinson, Ian

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NRF2 Mediates Therapeutic Resistance to Chemoradiation in Colorectal Cancer through a Metabolic Switch 由 O’Cathail, Séan M., Wu, Chieh-Hsi, Thomas, Rachael, Hawkins, Maria A., Maughan, Tim S., Lewis, Annabelle

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CRISPR-Cas9 Causes Chromosomal Instability and Rearrangements in Cancer Cell Lines, Detectable by Cytogenetic Methods 由 Rayner, Emily, Durin, Mary-Anne, Thomas, Rachael, Moralli, Daniela, O'Cathail, Sean M., Tomlinson, Ian, Green, Catherine M., Lewis, Annabelle

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The long noncoding RNA Kcnq1ot1 organises a lineage-specific nuclear domain for epigenetic gene silencing 由 Redrup, Lisa, Branco, Miguel R., Perdeaux, Elizabeth R., Krueger, Christel, Lewis, Annabelle, Santos, Fátima, Nagano, Takashi, Cobb, Bradley S., Fraser, Peter, Reik, Wolf

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Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5 由 Lewis, Annabelle, Segditsas, Stefania, Deheragoda, Maesha, Pollard, Patrick, Jeffery, Rosemary, Nye, Emma, Lockstone, Helen, Davis, Hayley, Clark, Susan, Stamp, Gordon, Poulsom, Richard, Wright, Nicholas, Tomlinson, Ian

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Hereditary mixed polyposis syndrome is caused by a 40kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1 由 Jaeger, Emma, Leedham, Simon, Lewis, Annabelle, Segditsas, Stefania, Becker, Martin, Cuadrado, Pedro Rodenas, Davis, Hayley, Kaur, Kulvinder, Heinimann, Karl, Howarth, Kimberley, East, James, Taylor, Jenny, Thomas, Huw, Tomlinson, Ian

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The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression 由 Thomas, Rachael, Trapani, Davide, Goodyer-Sait, Lily, Tomkova, Marketa, Fernandez-Rozadilla, Ceres, Sahnane, Nora, Woolley, Connor, Davis, Hayley, Chegwidden, Laura, Kriaucionis, Skirmantas, Maughan, Timothy, Leedham, Simon, Palles, Claire, Furlan, Daniela, Tomlinson, Ian, Lewis, Annabelle

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FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation 由 Babaei-Jadidi, Roya, Li, Ningning, Saadeddin, Anas, Spencer-Dene, Bradley, Jandke, Anett, Muhammad, Belal, Ibrahim, ElSayed E., Muraleedharan, Ranjithmenon, Abuzinadah, Mohammed, Davis, Hayley, Lewis, Annabelle, Watson, Susan, Behrens, Axel, Tomlinson, Ian, Nateri, Abdolrahman Shams

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The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability 由 Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle

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Correction to: The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability 由 Russell, Holly, Kedzierska, Katarzyna, Buchanan, Daniel D., Thomas, Rachael, Tham, Emma, Mints, Miriam, Keränen, Anne, Giles, Graham G., Southey, Melissa C., Milne, Roger L., Tomlinson, Ian, Church, David, Spurdle, Amanda B., O’Mara, Tracy A., Lewis, Annabelle

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A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts 由 Leedham, Simon J, Rodenas-Cuadrado, Pedro, Howarth, Kimberley, Lewis, Annabelle, Mallappa, Sreelakshmi, Segditsas, Stefania, Davis, Hayley, Jeffery, Rosemary, Rodriguez-Justo, Manuel, Keshav, Satish, Travis, Simon P L, Graham, Trevor A, East, James, Clark, Susan, Tomlinson, Ian P M

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Bone morphogenetic protein and Notch signalling crosstalk in poor‐prognosis, mesenchymal‐subtype colorectal cancer 由 Irshad, Shazia, Bansal, Mukesh, Guarnieri, Paolo, Davis, Hayley, Al Haj Zen, Ayman, Baran, Brygida, Pinna, Claudia Maria Assunta, Rahman, Haseeb, Biswas, Sujata, Bardella, Chiara, Jeffery, Rosemary, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Lewis, Annabelle, Leedham, Simon John

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A Polymorphic Enhancer near GREM1 Influences Bowel Cancer Risk through Differential CDX2 and TCF7L2 Binding 由 Lewis, Annabelle, Freeman-Mills, Luke, de la Calle-Mustienes, Elisa, Giráldez-Pérez, Rosa María, Davis, Hayley, Jaeger, Emma, Becker, Martin, Hubner, Nina C., Nguyen, Luan N., Zeron-Medina, Jorge, Bond, Gareth, Stunnenberg, Hendrik G., Carvajal, Jaime J., Gomez-Skarmeta, Jose Luis, Leedham, Simon, Tomlinson, Ian

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Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution 由 Baker, Ann-Marie, Huang, Weini, Wang, Xiao-Ming Mindy, Jansen, Marnix, Ma, Xiao-Jun, Kim, Jeffrey, Anderson, Courtney M., Wu, Xingyong, Pan, Liuliu, Su, Nan, Luo, Yuling, Domingo, Enric, Heide, Timon, Sottoriva, Andrea, Lewis, Annabelle, Beggs, Andrew D., Wright, Nicholas A., Rodriguez-Justo, Manuel, Park, Emily, Tomlinson, Ian, Graham, Trevor A.

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Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside of the crypt base stem cell niche 由 Davis, Hayley, Irshad, Shazia, Bansal, Mukesh, Rafferty, Hannah, Boitsova, Tatjana, Bardella, Chiara, Jaeger, Emma, Lewis, Annabelle, Freeman-Mills, Luke, Giner, Francesc Castro, Rodenas-Cuadrado, Pedro, Mallappa, Sreelakshmi, Clark, Susan, Thomas, Huw, Jeffery, Rosemary, Poulsom, Richard, Rodriguez-Justo, Manuel, Novelli, Marco, Chetty, Runjan, Silver, Andrew, Sansom, Owen James, Greten, Florian R, Wang, Lai Mun, East, James Edward, Tomlinson, Ian, Leedham, Simon John

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Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer 由 Tomlinson, Ian P. M., Carvajal-Carmona, Luis G., Dobbins, Sara E., Tenesa, Albert, Jones, Angela M., Howarth, Kimberley, Palles, Claire, Broderick, Peter, Jaeger, Emma E. M., Farrington, Susan, Lewis, Annabelle, Prendergast, James G. D., Pittman, Alan M., Theodoratou, Evropi, Olver, Bianca, Walker, Marion, Penegar, Steven, Barclay, Ella, Whiffin, Nicola, Martin, Lynn, Ballereau, Stephane, Lloyd, Amy, Gorman, Maggie, Lubbe, Steven, Howie, Bryan, Marchini, Jonathan, Ruiz-Ponte, Clara, Fernandez-Rozadilla, Ceres, Castells, Antoni, Carracedo, Angel, Castellvi-Bel, Sergi, Duggan, David, Conti, David, Cazier, Jean-Baptiste, Campbell, Harry, Sieber, Oliver, Lipton, Lara, Gibbs, Peter, Martin, Nicholas G., Montgomery, Grant W., Young, Joanne, Baird, Paul N., Gallinger, Steven, Newcomb, Polly, Hopper, John, Jenkins, Mark A., Aaltonen, Lauri A., Kerr, David J., Cheadle, Jeremy, Pharoah, Paul, Casey, Graham, Houlston, Richard S., Dunlop, Malcolm G.

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Five endometrial cancer risk loci identified through genome-wide association analysis 由 Cheng, Timothy HT, Thompson, Deborah J, O’Mara, Tracy A, Painter, Jodie N, Glubb, Dylan M, Flach, Susanne, Lewis, Annabelle, French, Juliet D, Freeman-Mills, Luke, Church, David, Gorman, Maggie, Martin, Lynn, Hodgson, Shirley, Webb, Penelope M, Attia, John, Holliday, Elizabeth G, McEvoy, Mark, Scott, Rodney J, Henders, Anjali K, Martin, Nicholas G, Montgomery, Grant W, Nyholt, Dale R, Ahmed, Shahana, Healey, Catherine S, Shah, Mitul, Dennis, Joe, Fasching, Peter A, Beckmann, Matthias W, Hein, Alexander, Ekici, Arif B, Hall, Per, Czene, Kamila, Darabi, Hatef, Li, Jingmei, Dörk, Thilo, Dürst, Matthias, Hillemanns, Peter, Runnebaum, Ingo, Amant, Frederic, Schrauwen, Stefanie, Zhao, Hui, Lambrechts, Diether, Depreeuw, Jeroen, Dowdy, Sean C, Goode, Ellen L, Fridley, Brooke L, Winham, Stacey J, Njølstad, Tormund S, Salvesen, Helga B, Trovik, Jone, Werner, Henrica MJ, Ashton, Katie, Otton, Geoffrey, Proietto, Tony, Liu, Tao, Mints, Miriam, Tham, Emma, Consortium, CHIBCHA, Jun Li, Mulin, Yip, Shun H, Wang, Junwen, Bolla, Manjeet K, Michailidou, Kyriaki, Wang, Qin, Tyrer, Jonathan P, Dunlop, Malcolm, Houlston, Richard, Palles, Claire, Hopper, John L, Peto, Julian, Swerdlow, Anthony J, Burwinkel, Barbara, Brenner, Hermann, Meindl, Alfons, Brauch, Hiltrud, Lindblom, Annika, Chang-Claude, Jenny, Couch, Fergus J, Giles, Graham G, Kristensen, Vessela N, Cox, Angela, Cunningham, Julie M, Pharoah, Paul D P, Dunning, Alison M, Edwards, Stacey L, Easton, Douglas F, Tomlinson, Ian, Spurdle, Amanda B

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