检索结果 - Lessene, Guillaume

Inhibitors of SARS-CoV-2 PLpro 由 Calleja, Dale J., Lessene, Guillaume, Komander, David

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Crystallization and preliminary X-ray characterization of Epstein–Barr virus BHRF1 in complex with a benzoylurea peptidomimetic 由 Caria, Sofia, Chugh, Srishti, Nhu, Duong, Lessene, Guillaume, Kvansakul, Marc

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Dual drug targeting to kill colon cancers 由 Corona, Silvia Paola, Walker, Francesca, Weinstock, Janet, Lessene, Guillaume, Faux, Maree, Burgess, Antony W.

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Removal of BFL-1 sensitises some melanoma cells to killing by BH3 mimetic drugs 由 Gangoda, Lahiru, Schenk, Robyn L., Tai, Lin, Szeto, Pacman, Cheung, Jen G., Strasser, Andreas, Lessene, Guillaume, Shackleton, Mark, Herold, Marco J.

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Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands 由 Lee, Erinna F., Czabotar, Peter E., Yang, Hong, Sleebs, Brad E., Lessene, Guillaume, Colman, Peter M., Smith, Brian J., Fairlie, W. Douglas

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BAX-BAK1-independent LC3B lipidation by BH3 mimetics is unrelated to BH3 mimetic activity and has only minimal effects on autophagic flux 由 Reljic, Boris, Conos, Stephanie, Lee, Erinna F., Garnier, Jean-Marc, Dong, Li, Lessene, Guillaume, Fairlie, W. Douglas, Vaux, David L., Lindqvist, Lisa M.

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The BH3-only proteins BIM and PUMA are not critical for the reticulocyte apoptosis caused by loss of the pro-survival protein BCL-XL 由 Delbridge, Alex RD, Aubrey, Brandon J, Hyland, Craig, Bernardini, Jonathan P, Di Rago, Ladina, Garnier, Jean-Marc, Lessene, Guillaume, Strasser, Andreas, Alexander, Warren S, Grabow, Stephanie

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Hepatocyte growth factor renders BRAF mutant human melanoma cell lines resistant to PLX4032 by downregulating the pro-apoptotic BH3-only proteins PUMA and BIM 由 Rohrbeck, Leona, Gong, Jia-Nan, Lee, Erinna F, Kueh, Andrew J, Behren, Andreas, Tai, Lin, Lessene, Guillaume, Huang, David C S, Fairlie, Walter D, Strasser, Andreas, Herold, Marco J

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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production 由 White, Michael J., McArthur, Kate, Metcalf, Donald, Lane, Rachael M., Cambier, John C., Herold, Marco J., van Delft, Mark F., Bedoui, Sammy, Lessene, Guillaume, Ritchie, Matthew E., Huang, David C.S., Kile, Benjamin T.

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BCL-XL inhibition by BH3-mimetic drugs induces apoptosis in models of Epstein-Barr virus–associated T/NK-cell lymphoma 由 Sejic, Nenad, George, Lindsay C., Tierney, Rosemary J., Chang, Catherine, Kondrashova, Olga, MacKinnon, Ruth N., Lan, Ping, Bell, Andrew I., Lessene, Guillaume, Long, Heather M., Strasser, Andreas, Shannon-Lowe, Claire, Kelly, Gemma L.

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Inhibition of Hematopoietic Cell Kinase Activity Suppresses Myeloid Cell-Mediated Colon Cancer Progression 由 Poh, Ashleigh R., Love, Christopher G., Masson, Frederick, Preaudet, Adele, Tsui, Cary, Whitehead, Lachlan, Monard, Simon, Khakham, Yelena, Burstroem, Lotta, Lessene, Guillaume, Sieber, Oliver, Lowell, Clifford, Putoczki, Tracy L., O’Donoghue, Robert J.J., Ernst, Matthias

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Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations 由 Birkinshaw, Richard W., Gong, Jia-nan, Luo, Cindy S., Lio, Daisy, White, Christine A., Anderson, Mary Ann, Blombery, Piers, Lessene, Guillaume, Majewski, Ian J., Thijssen, Rachel, Roberts, Andrew W., Huang, David C. S., Colman, Peter M., Czabotar, Peter E.

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BCL‐XL exerts a protective role against anemia caused by radiation‐induced kidney damage 由 Brinkmann, Kerstin, Waring, Paul, Glaser, Stefan P, Wimmer, Verena, Cottle, Denny L, Tham, Ming Shen, Nhu, Duong, Whitehead, Lachlan, Delbridge, Alex RD, Lessene, Guillaume, Smyth, Ian M, Herold, Marco J, Kelly, Gemma L, Grabow, Stephanie, Strasser, Andreas

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BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells 由 Moujalled, Diane, Southon, Adam G., Saleh, Eiman, Brinkmann, Kerstin, Ke, Francine, Iliopoulos, Melinda, Cross, Ryan S., Jenkins, Misty R., Nhu, Duong, Wang, Zilu, Shi, Melissa X., Kluck, Ruth M., Lessene, Guillaume, Grabow, Stephanie, Bush, Ashley I., Strasser, Andreas

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Defining the susceptibility of colorectal cancers to BH3-mimetic compounds 由 Luo, Ming-Jie, Palmieri, Michelle, Riffkin, Chris D., Sakthianandeswaren, Anuratha, Djajawi, Tirta Mario, Hirokawa, Yumiko, Shuttleworth, Victoria, Segal, David H., White, Christine A., Nhu, Duong, Lessene, Guillaume, Lee, Margaret, Gibbs, Peter, Huang, David C. S., Sieber, Oliver M., Gong, Jia-nan

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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis 由 Meng, Yanxiang, Davies, Katherine A., Fitzgibbon, Cheree, Young, Samuel N., Garnish, Sarah E., Horne, Christopher R., Luo, Cindy, Garnier, Jean-Marc, Liang, Lung-Yu, Cowan, Angus D., Samson, Andre L., Lessene, Guillaume, Sandow, Jarrod J., Czabotar, Peter E., Murphy, James M.

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ATF3 repression of BCL-X(L) determines apoptotic sensitivity to HDAC inhibitors across tumour types 由 Chueh, Anderly C., Tse, Janson WT, Dickinson, Michael, Ioannidis, Paul, Jenkins, Laura, Togel, Lars, Tan, BeeShin, Luk, Ian, Davalos-Salas, Mercedes, Nightingale, Rebecca, Thompson, Matthew R., Williams, Bryan R.G., Lessene, Guillaume, Lee, Erinna, Fairlie, Walter D., Dhillon, Amardeep S., Mariadason, John M.

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The Lck inhibitor, AMG-47a, blocks necroptosis and implicates RIPK1 in signalling downstream of MLKL 由 Jacobsen, Annette V., Pierotti, Catia L., Lowes, Kym N., Au, Amanda E., Zhang, Ying, Etemadi, Nima, Fitzgibbon, Cheree, Kersten, Wilhelmus J. A., Samson, André L., van Delft, Mark F., Huang, David C. S., Sabroux, Hélène Jousset, Lessene, Guillaume, Silke, John, Murphy, James M.

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Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer 由 Berger, Stephanie, Procko, Erik, Margineantu, Daciana, Lee, Erinna F, Shen, Betty W, Zelter, Alex, Silva, Daniel-Adriano, Chawla, Kusum, Herold, Marco J, Garnier, Jean-Marc, Johnson, Richard, MacCoss, Michael J, Lessene, Guillaume, Davis, Trisha N, Stayton, Patrick S, Stoddard, Barry L, Fairlie, W Douglas, Hockenbery, David M, Baker, David

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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms 由 Grohmann, Christoph, Magtoto, Charlene M., Walker, Joel R., Chua, Ngee Kiat, Gabrielyan, Anna, Hall, Mary, Cobbold, Simon A., Mieruszynski, Stephen, Brzozowski, Martin, Simpson, Daniel S., Dong, Hao, Dorizzi, Bridget, Jacobsen, Annette V., Morrish, Emma, Silke, Natasha, Murphy, James M., Heath, Joan K., Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Lessene, Guillaume, Silke, John, Feltham, Rebecca

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