Výsledky vyhledávání - Les A. Dakin

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  1. 1
    AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia

    AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia Autor Erika Krasnickas Keeton, Kristen McEachern, Keith S. Dillman, Sangeetha Palakurthi, Yichen Cao, Michael Grondine, Surinder Kaur, Suping Wang, Yuching Chen, Allan Wu, Minhui Shen, Francis D. Gibbons, Michelle L. Lamb, Xiaolan Zheng, Richard M. Stone, Daniel J. DeAngelo, Leonidas C. Platanias, Les A. Dakin, Huawei Chen, Paul D. Lyne, Dennis Huszar

    Vydáno 2013
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  2. 2
    Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas

    Identification of (<i>R</i>)-<i>N</i>-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1<i>H</i>-indole-3-car... Autor Rishi G. Vaswani, Victor Gehling, Les A. Dakin, Andrew S. Cook, Christopher G. Nasveschuk, Martin Duplessis, Priyadarshini Iyer, Srividya Balasubramanian, Feng Zhao, Andrew C. Good, Robert M. Campbell, Christina Lee, Nico Cantone, Richard Cummings, Emmanuel Normant, Steven F. Bellon, Brian K. Albrecht, Jean-Christophe Harmange, Patrick Trojer, James E. Audia, Ying Zhang, N. Justin, Shuyang Chen, J. Wilson, S.J. Gamblin

    Vydáno 2016
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  3. 3
    Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains

    Diving into the Water: Inducible Binding Conformations for BRD4, TAF1(2), BRD9, and CECR2 Bromodomains Autor Terry D. Crawford, Vickie Tsui, E. Megan Flynn, Shumei Wang, Alexander M. Taylor, Alexandre Côté, James E. Audia, Maureen H. Beresini, Daniel J. Burdick, Richard Cummings, Les A. Dakin, Martin Duplessis, Andrew C. Good, Michael C. Hewitt, Hon-Ren Huang, Hariharan Jayaram, James R. Kiefer, Ying Jiang, Jeremy Murray, Christopher G. Nasveschuk, Eneida Pardo, Florence Poy, F. Anthony Romero, Yong Tang, Jian Wang, Zhaowu Xu, Laura E. Zawadzke, Xiaoyu Zhu, Brian K. Albrecht, Steven Magnuson, S.F. Bellon, Andrea G. Cochran

    Vydáno 2016
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