Kết quả tìm kiếm - Lepsik, Martin

Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro Bằng Pytelková, Jana, Lepšík, Martin, Šanda, Miloslav, Talacko, Pavel, Marešová, Lucie, Mareš, Michael

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Aurora kinase inhibitors: Progress towards the clinic Bằng Kollareddy, Madhu, Zheleva, Daniella, Dzubak, Petr, Brahmkshatriya, Pathik Subhashchandra, Lepsik, Martin, Hajduch, Marian

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Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis Bằng Dostál, Jiří, Brynda, Jiří, Vaňková, Lucie, Zia, Syeda Rehana, Pichová, Iva, Heidingsfeld, Olga, Lepšík, Martin

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Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures Bằng Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido

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Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein–Ligand Complexes in Cognate Docking Bằng Ajani, Haresh, Pecina, Adam, Eyrilmez, Saltuk M., Fanfrlík, Jindřich, Haldar, Susanta, Řezáč, Jan, Hobza, Pavel, Lepšík, Martin

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The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis Bằng Machová, Iva, Hubálek, Martin, Lepšík, Martin, Bednárová, Lucie, Pazderková, Markéta, Kopecký, Vladimír, Snášel, Jan, Dostál, Jiří, Pichová, Iva

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Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners Bằng Gemperle, Jakub, Hexnerová, Rozálie, Lepšík, Martin, Tesina, Petr, Dibus, Michal, Novotný, Marian, Brábek, Jan, Veverka, Václav, Rosel, Daniel

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Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality Bằng Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

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Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex Bằng Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

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In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions Bằng Giacobelli, Valerio G, Fujishima, Kosuke, Lepšík, Martin, Tretyachenko, Vyacheslav, Kadavá, Tereza, Makarov, Mikhail, Bednárová, Lucie, Novák, Petr, Hlouchová, Klára

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Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir Bằng Šašková, Klára Grantz, Kožíšek, Milan, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Václavíková, Jana, Kagan, Ron M., Machala, Ladislav, Konvalinka, Jan

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Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations Bằng Mader, Pavel, Pecina, Adam, Cígler, Petr, Lepšík, Martin, Šícha, Václav, Hobza, Pavel, Grüner, Bohumír, Fanfrlík, Jindřich, Brynda, Jiří, Řezáčová, Pavlína

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Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity Bằng van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles AB, Nijhuis, Monique

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Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles Bằng Strohalmová-Bohmová, Karolína, Spiwok, Vojtěch, Lepšík, Martin, Hadravová, Romana, Křížová, Ivana, Ulbrich, Pavel, Pichová, Iva, Bednárová, Lucie, Ruml, Tomáš, Rumlová, Michaela

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Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes Bằng Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael

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Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni Bằng Jílková, Adéla, Řezáčová, Pavlína, Lepšík, Martin, Horn, Martin, Váchová, Jana, Fanfrlík, Jindřich, Brynda, Jiří, McKerrow, James H., Caffrey, Conor R., Mareš, Michael

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Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity Bằng Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael

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Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors Bằng Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael

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General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases Bằng Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido

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Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses Bằng Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří

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