Search Results - Lepsik, Martin

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  1. 1
    Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro

    Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro by Pytelková, Jana, Lepšík, Martin, Šanda, Miloslav, Talacko, Pavel, Marešová, Lucie, Mareš, Michael

    Published 2012
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  2. 2
    Aurora kinase inhibitors: Progress towards the clinic

    Aurora kinase inhibitors: Progress towards the clinic by Kollareddy, Madhu, Zheleva, Daniella, Dzubak, Petr, Brahmkshatriya, Pathik Subhashchandra, Lepsik, Martin, Hajduch, Marian

    Published 2012
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  3. 3
    Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis

    Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis by Dostál, Jiří, Brynda, Jiří, Vaňková, Lucie, Zia, Syeda Rehana, Pichová, Iva, Heidingsfeld, Olga, Lepšík, Martin

    Published 2021
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  4. 4
    Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures

    Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures by Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido

    Published 2014
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  5. 5
    Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein–Ligand Complexes in Cognate Docking

    Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein–Ligand Complexes in Cognate Docking by Ajani, Haresh, Pecina, Adam, Eyrilmez, Saltuk M., Fanfrlík, Jindřich, Haldar, Susanta, Řezáč, Jan, Hobza, Pavel, Lepšík, Martin

    Published 2017
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  6. 6
    The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis

    The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis by Machová, Iva, Hubálek, Martin, Lepšík, Martin, Bednárová, Lucie, Pazderková, Markéta, Kopecký, Vladimír, Snášel, Jan, Dostál, Jiří, Pichová, Iva

    Published 2017
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  7. 7
    Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners

    Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners by Gemperle, Jakub, Hexnerová, Rozálie, Lepšík, Martin, Tesina, Petr, Dibus, Michal, Novotný, Marian, Brábek, Jan, Veverka, Václav, Rosel, Daniel

    Published 2017
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  8. 8
    Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality

    Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality by Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

    Published 2013
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  9. 9
    Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

    Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex by Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

    Published 2014
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  10. 10
    In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions

    In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions by Giacobelli, Valerio G, Fujishima, Kosuke, Lepšík, Martin, Tretyachenko, Vyacheslav, Kadavá, Tereza, Makarov, Mikhail, Bednárová, Lucie, Novák, Petr, Hlouchová, Klára

    Published 2022
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  11. 11
    Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir

    Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir by Šašková, Klára Grantz, Kožíšek, Milan, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Václavíková, Jana, Kagan, Ron M., Machala, Ladislav, Konvalinka, Jan

    Published 2008
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  12. 12
    Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations

    Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations by Mader, Pavel, Pecina, Adam, Cígler, Petr, Lepšík, Martin, Šícha, Václav, Hobza, Pavel, Grüner, Bohumír, Fanfrlík, Jindřich, Brynda, Jiří, Řezáčová, Pavlína

    Published 2014
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  13. 13
    Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity

    Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity by van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles AB, Nijhuis, Monique

    Published 2012
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  14. 14
    Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles

    Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles by Strohalmová-Bohmová, Karolína, Spiwok, Vojtěch, Lepšík, Martin, Hadravová, Romana, Křížová, Ivana, Ulbrich, Pavel, Pichová, Iva, Bednárová, Lucie, Ruml, Tomáš, Rumlová, Michaela

    Published 2014
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  15. 15
    Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes

    Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes by Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael

    Published 2022
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  16. 16
    Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni

    Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni by Jílková, Adéla, Řezáčová, Pavlína, Lepšík, Martin, Horn, Martin, Váchová, Jana, Fanfrlík, Jindřich, Brynda, Jiří, McKerrow, James H., Caffrey, Conor R., Mareš, Michael

    Published 2011
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  17. 17
    Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity

    Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity by Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael

    Published 2020
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  18. 18
    Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

    Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors by Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael

    Published 2020
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  19. 19
    General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases

    General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases by Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido

    Published 2017
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  20. 20
    Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses

    Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses by Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří

    Published 2019
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