Resultats de la cerca - Lepsik, Martin

Enzymatic activity and immunoreactivity of Aca s 4, an alpha-amylase allergen from the storage mite Acarus siro per Pytelková, Jana, Lepšík, Martin, Šanda, Miloslav, Talacko, Pavel, Marešová, Lucie, Mareš, Michael

Obtenir text complet Obtenir text complet Obtenir text complet

Aurora kinase inhibitors: Progress towards the clinic per Kollareddy, Madhu, Zheleva, Daniella, Dzubak, Petr, Brahmkshatriya, Pathik Subhashchandra, Lepsik, Martin, Hajduch, Marian

Obtenir text complet Obtenir text complet Obtenir text complet

Structural determinants for subnanomolar inhibition of the secreted aspartic protease Sapp1p from Candida parapsilosis per Dostál, Jiří, Brynda, Jiří, Vaňková, Lucie, Zia, Syeda Rehana, Pichová, Iva, Heidingsfeld, Olga, Lepšík, Martin

Obtenir text complet Obtenir text complet Obtenir text complet

Substrate binding and specificity of rhomboid intramembrane protease revealed by substrate–peptide complex structures per Zoll, Sebastian, Stanchev, Stancho, Began, Jakub, Škerle, Jan, Lepšík, Martin, Peclinovská, Lucie, Majer, Pavel, Strisovsky, Kvido

Obtenir text complet Obtenir text complet Obtenir text complet

Superior Performance of the SQM/COSMO Scoring Functions in Native Pose Recognition of Diverse Protein–Ligand Complexes in Cognate Docking per Ajani, Haresh, Pecina, Adam, Eyrilmez, Saltuk M., Fanfrlík, Jindřich, Haldar, Susanta, Řezáč, Jan, Hobza, Pavel, Lepšík, Martin

Obtenir text complet Obtenir text complet Obtenir text complet

The Role of Cysteine Residues in Catalysis of Phosphoenolpyruvate Carboxykinase from Mycobacterium tuberculosis per Machová, Iva, Hubálek, Martin, Lepšík, Martin, Bednárová, Lucie, Pazderková, Markéta, Kopecký, Vladimír, Snášel, Jan, Dostál, Jiří, Pichová, Iva

Obtenir text complet Obtenir text complet Obtenir text complet

Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners per Gemperle, Jakub, Hexnerová, Rozálie, Lepšík, Martin, Tesina, Petr, Dibus, Michal, Novotný, Marian, Brábek, Jan, Veverka, Václav, Rosel, Daniel

Obtenir text complet Obtenir text complet Obtenir text complet

Structural Integrity of the B24 Site in Human Insulin Is Important for Hormone Functionality per Žáková, Lenka, Kletvíková, Emília, Veverka, Václav, Lepšík, Martin, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

Obtenir text complet Obtenir text complet Obtenir text complet

Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex per Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.

Obtenir text complet Obtenir text complet Obtenir text complet

In Vitro Evolution Reveals Noncationic Protein–RNA Interaction Mediated by Metal Ions per Giacobelli, Valerio G, Fujishima, Kosuke, Lepšík, Martin, Tretyachenko, Vyacheslav, Kadavá, Tereza, Makarov, Mikhail, Bednárová, Lucie, Novák, Petr, Hlouchová, Klára

Obtenir text complet Obtenir text complet Obtenir text complet

Enzymatic and structural analysis of the I47A mutation contributing to the reduced susceptibility to HIV protease inhibitor lopinavir per Šašková, Klára Grantz, Kožíšek, Milan, Lepšík, Martin, Brynda, Jiří, Řezáčová, Pavlína, Václavíková, Jana, Kagan, Ron M., Machala, Ladislav, Konvalinka, Jan

Obtenir text complet Obtenir text complet Obtenir text complet

Carborane-Based Carbonic Anhydrase Inhibitors: Insight into CAII/CAIX Specificity from a High-Resolution Crystal Structure, Modeling, and Quantum Chemical Calculations per Mader, Pavel, Pecina, Adam, Cígler, Petr, Lepšík, Martin, Šícha, Václav, Hobza, Pavel, Grüner, Bohumír, Fanfrlík, Jindřich, Brynda, Jiří, Řezáčová, Pavlína

Obtenir text complet Obtenir text complet Obtenir text complet

Modulation of HIV-1 Gag NC/p1 cleavage efficiency affects protease inhibitor resistance and viral replicative capacity per van Maarseveen, Noortje M, Andersson, Dan, Lepšík, Martin, Fun, Axel, Schipper, Pauline J, de Jong, Dorien, Boucher, Charles AB, Nijhuis, Monique

Obtenir text complet Obtenir text complet Obtenir text complet

Role of Mason-Pfizer Monkey Virus CA-NC Spacer Peptide-Like Domain in Assembly of Immature Particles per Strohalmová-Bohmová, Karolína, Spiwok, Vojtěch, Lepšík, Martin, Hadravová, Romana, Křížová, Ivana, Ulbrich, Pavel, Pichová, Iva, Bednárová, Lucie, Ruml, Tomáš, Rumlová, Michaela

Obtenir text complet Obtenir text complet Obtenir text complet

Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes per Benýšek, Jakub, Buša, Michal, Rubešová, Petra, Fanfrlík, Jindřich, Lepšík, Martin, Brynda, Jiří, Matoušková, Zuzana, Bartz, Ulrike, Horn, Martin, Gütschow, Michael, Mareš, Michael

Obtenir text complet Obtenir text complet Obtenir text complet

Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni per Jílková, Adéla, Řezáčová, Pavlína, Lepšík, Martin, Horn, Martin, Váchová, Jana, Fanfrlík, Jindřich, Brynda, Jiří, McKerrow, James H., Caffrey, Conor R., Mareš, Michael

Obtenir text complet Obtenir text complet Obtenir text complet

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to Schistosoma mansoni: Structural and Mechanistic Insights into Chemotype Reactivity per Jílková, Adéla, Horn, Martin, Fanfrlík, Jindřich, Küppers, Jim, Pachl, Petr, Řezáčová, Pavlína, Lepšík, Martin, Fajtová, Pavla, Rubešová, Petra, Chanová, Marta, Caffrey, Conor R., Gütschow, Michael, Mareš, Michael

Obtenir text complet Obtenir text complet Obtenir text complet

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors per Jílková, Adéla, Rubešová, Petra, Fanfrlík, Jindřich, Fajtová, Pavla, Řezáčová, Pavlína, Brynda, Jiří, Lepšík, Martin, Mertlíková-Kaiserová, Helena, Emal, Cory D., Renslo, Adam R., Roush, William R., Horn, Martin, Caffrey, Conor R., Mareš, Michael

Obtenir text complet Obtenir text complet Obtenir text complet

General and Modular Strategy for Designing Potent, Selective, and Pharmacologically Compliant Inhibitors of Rhomboid Proteases per Tichá, Anežka, Stanchev, Stancho, Vinothkumar, Kutti R., Mikles, David C., Pachl, Petr, Began, Jakub, Škerle, Jan, Švehlová, Kateřina, Nguyen, Minh T.N., Verhelst, Steven H.L., Johnson, Darren C., Bachovchin, Daniel A., Lepšík, Martin, Majer, Pavel, Strisovsky, Kvido

Obtenir text complet Obtenir text complet Obtenir text complet

Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses per Macháčková, Kateřina, Mlčochová, Květoslava, Potalitsyn, Pavlo, Hanková, Kateřina, Socha, Ondřej, Buděšínský, Miloš, Muždalo, Anja, Lepšík, Martin, Černeková, Michaela, Radosavljević, Jelena, Fábry, Milan, Mitrová, Katarína, Chrudinová, Martina, Lin, Jingjing, Yurenko, Yevgen, Hobza, Pavel, Selicharová, Irena, Žáková, Lenka, Jiráček, Jiří

Obtenir text complet Obtenir text complet Obtenir text complet