Resultats de la cerca - Laura Sepp‐Lorenzino

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  1. 1
    A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells

    A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells per Laura Sepp‐Lorenzino, Neal Rosen

    Publicat 1998
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  2. 2
    Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma

    Expression of Asialoglycoprotein Receptor 1 in Human Hepatocellular Carcinoma per Bin Shi, Marc Abrams, Laura Sepp‐Lorenzino

    Publicat 2013
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  3. 3
    Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes.

    Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. per Alexander Vinitsky, Christopher Cardozo, Laura Sepp‐Lorenzino, Charlene Michaud, Marian Orłowski

    Publicat 1994
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  4. 4
    Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases

    Herbimycin A Induces the 20 S Proteasome- and Ubiquitin-dependent Degradation of Receptor Tyrosine Kinases per Laura Sepp‐Lorenzino, Zhengping Ma, David Lebwohl, Alexander Vinitsky, Neal Rosen

    Publicat 1995
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  5. 5
    Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

    Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. per Hubert Serve, Nelson S. Yee, Giulia Maria Stella, Laura Sepp‐Lorenzino, James C. Tan, Peter Besmer

    Publicat 1995
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  6. 6
    Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells

    Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells per Bin Shi, Laura Sepp‐Lorenzino, Marco di Prisco, Peter S. Linsley, Tiziana DeAngelis, Renato Baserga

    Publicat 2007
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  7. 7
    Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90

    Pharmacologic shifting of a balance between protein refolding and degradation mediated by Hsp90 per Christine Schneider, Laura Sepp‐Lorenzino, Elmar Nimmesgern, Ouathek Ouerfelli, Samuel J. Danishefsky, Neal Rosen, F. Ulrich Hartl

    Publicat 1996
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  8. 8
    A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells

    A small molecule designed to bind to the adenine nucleotide pocket of Hsp90 causes Her2 degradation and the growth arrest and differentiation of breast cancer cells per Gabriela Chiosis, Merna N. Timaul, Brian S. Lucas, Pamela N. Münster, Fuzhong F. Zheng, Laura Sepp‐Lorenzino, Neal Rosen

    Publicat 2001
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  9. 9
    Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses

    Mechanistically Probing Lipid-siRNA Nanoparticle-associated Toxicities Identifies Jak Inhibitors Effective in Mitigating Multifaceted Toxic Responses per Weikang Tao, Xianzhi Mao, Joseph P. Davide, Bruce Ng, Mingmei Cai, Paul A. Burke, Alan B. Sachs, Laura Sepp‐Lorenzino

    Publicat 2010
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  10. 10
    Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver

    Noninvasive Imaging of Lipid Nanoparticle–Mediated Systemic Delivery of Small-Interfering RNA to the Liver per Weikang Tao, Joseph P. Davide, Mingmei Cai, Guojun Zhang, Victoria J. South, Andrea Matter, Bruce Ng, Ye Zhang, Laura Sepp‐Lorenzino

    Publicat 2010
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  11. 11
    Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

    Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage per Weikang Tao, Victoria J. South, Yun Zhang, Joseph P. Davide, Linda Farrell, Nancy E. Kohl, Laura Sepp‐Lorenzino, Robert B. Lobell

    Publicat 2005
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  12. 12
    Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

    Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones per Mark M. Moasser, Laura Sepp‐Lorenzino, Nancy E. Kohl, Allen Oliff, Aaron Balog, Dai‐Shi Su, Samuel J. Danishefsky, Neal Rosen

    Publicat 1998
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  13. 13
    Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery

    Biodistribution of Small Interfering RNA at the Organ and Cellular Levels after Lipid Nanoparticle-mediated Delivery per Bin Shi, Ed Keough, Andrea Matter, Karen Leander, Stephanie Young, Ed Carlini, Alan B. Sachs, Weikang Tao, Marc Abrams, Bonnie J. Howell, Laura Sepp‐Lorenzino

    Publicat 2011
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  14. 14
    Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

    Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth per Tayeba Khan, Hans Weber, Jillian DiMuzio, Andrea Matter, Belma Dogdas, Tosha Shah, Anil Thankappan, Jyoti Disa, Vasant Jadhav, Laura S. Lubbers, Laura Sepp‐Lorenzino, Walter Strapps, Marija Tadin‐Strapps

    Publicat 2016
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  15. 15
    Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment

    Evaluation of Efficacy, Biodistribution, and Inflammation for a Potent siRNA Nanoparticle: Effect of Dexamethasone Co-treatment per Marc Abrams, Martin L. Koser, Jessica Seitzer, Stephanie Williams, Martha A. DiPietro, Weimin Wang, Andrew W. Shaw, Xianzhi Mao, Vasant Jadhav, Joseph P. Davide, Paul A. Burke, Alan B. Sachs, Steven M. Stirdivant, Laura Sepp‐Lorenzino

    Publicat 2009
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  16. 16
    Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

    Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice per Thomas Michler, Anna D. Kosinska, Julia Festag, Till Bunse, Jinpeng Su, Marc Ringelhan, Hortenzia Imhof, Dirk Grimm, Katja Steiger, Carolin Mogler, Mathias Heikenwälder, Marie-Louise Michel, Carlos A. Guzmán, Stuart Milstein, Laura Sepp‐Lorenzino, Percy A. Knolle, Ulrike Protzer

    Publicat 2020
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  17. 17
    Quantitative evaluation of siRNA delivery in vivo

    Quantitative evaluation of siRNA delivery in vivo per Yi Pei, Paula J. Hancock, Hangchun Zhang, René Bartz, Craig Cherrin, Nathalie Innocent, Colin J. Pomerantz, Jessica Seitzer, Martin L. Koser, Marc Abrams, Yan Xu, Nelly A. Kuklin, Paul A. Burke, Alan B. Sachs, Laura Sepp‐Lorenzino, Stanley F. Barnett

    Publicat 2010
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  18. 18
    Centyrin ligands for extrahepatic delivery of siRNA

    Centyrin ligands for extrahepatic delivery of siRNA per Donna Klein, Shalom D. Goldberg, Christopher S. Theile, Richard Dambra, Kathleen Haskell, Elise Kuhar, Tricia Lin, Rubina Parmar, Muthiah Manoharan, Mark C. Richter, Mei‐Zhen Wu, Jeannine Mendrola Zarazowski, Vasant Jadhav, Martin A. Maier, Laura Sepp‐Lorenzino, Karyn T. O’Neil, Vadim Dudkin

    Publicat 2021
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  19. 19
    An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

    An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo per Craig Cherrin, Kathleen Haskell, Bonnie J. Howell, Raymond C. F. Jones, Karen Leander, R. Robinson, Aubrey Watkins, Mark T. Bilodeau, J. M. HOFFMAN, Philip E.J. Sanderson, George D. Hartman, E. Mahan, Thomayant Prueksaritanont, Guoqiang Jiang, Qing‐Bai She, Neal Rosen, Laura Sepp‐Lorenzino, Deborah Defeo-Jones, Hans E. Huber

    Publicat 2010
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  20. 20
    Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials

    Evaluation of RNAi therapeutics VIR-2218 and ALN-HBV for chronic hepatitis B: Results from randomized clinical trials per Ed Gane, Young‐Suk Lim, Jae Bum Kim, Vasant Jadhav, Ling Shen, Anna I. Bakardjiev, Stephen A. Huang, Andrea L. Cathcart, Florian A. Lempp, Maja M. Janas, Daniel Cloutier, Charalambos Kaittanis, Laura Sepp‐Lorenzino, Gregory Hinkle, Jörg Täubel, Patrick Haslett, Stuart Milstein, Yesseinia I. Angleró-Rodríguez, Christy M. Hebner, Phillip S. Pang, Man‐Fung Yuen

    Publicat 2023
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