Search Results - Lara Ward
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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for <i>PIK3CA</i>-Dependent Breast Cancers by Kevin Hudson, Urs J. Hancox, Cath Trigwell, Robert McEwen, Urszula M. Polanska, Myria Nikolaou, Pablo Morentin Gutierrez, Alvaro Avivar‐Valderas, Oona Delpuech, Phillippa Dudley, Lyndsey Hanson, Rebecca Ellston, Alys Jones, Marie Cumberbatch, Sabina Cosulich, Lara Ward, Francisco Cruzalegui, Stephen Green
Published 2016Artigo -
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Inhibition of PI3Kβ Signaling with AZD8186 Inhibits Growth of PTEN-Deficient Breast and Prostate Tumors Alone and in Combination with Docetaxel by Urs J. Hancox, Sabina Cosulich, Lyndsey Hanson, Cath Trigwell, Carol Lenaghan, Rebecca Ellston, Hannah Dry, Claire Crafter, Bernard Barlaam, Martina Fitzek, Paul D. Smith, Donald Ogilvie, Celina M. D’Cruz, Lillian Castriotta, Stephen R. Wedge, Lara Ward, Steve Powell, Mandy Lawson, Barry R. Davies, Elizabeth A. Harrington, Emily Foster, Marie Cumberbatch, Stephen Green, Simon T. Barry
Published 2014Artigo
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Biochemistry
Cancer
Cancer research
Chemistry
Internal medicine
Medicine
PI3K/AKT/mTOR pathway
Apoptosis
Biology
Breast cancer
Cell biology
Cell growth
Docetaxel
Drug
Estrogen receptor
Growth inhibition
PTEN
Pharmacology
Prostate
Prostate cancer
Protein kinase B
Signal transduction
Therapeutic index
Triple-negative breast cancer