Søgeresultater - Lansbury, Peter

Evolution of amyloid: What normal protein folding may tell us about fibrillogenesis and disease af Lansbury, Peter T.

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A possible therapeutic target for Lou Gehrig's disease af Ray, Soumya S., Lansbury, Peter T.

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A computer program for the estimation of protein and nucleic acid sequence diversity in random point mutagenesis libraries af Volles, Michael J., Lansbury, Peter T.

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Relationships between the sequence of α-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity af Volles, Michael J., Lansbury, Peter T.

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N-terminal deletion does not affect α-synuclein membrane binding, self-association and toxicity in human neuroblastoma cells, unlike yeast af Vamvaca, Katherina, Lansbury, Peter T., Stefanis, Leonidas

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The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast af Vamvaca, Katherina, Volles, Michael J., Lansbury, Peter T.

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Amyloid diseases: Abnormal protein aggregation in neurodegeneration af Koo, Edward H., Lansbury, Peter T., Kelly, Jeffery W.

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Small-molecule-mediated stabilization of familial amyotrophic lateral sclerosis-linked superoxide dismutase mutants against unfolding and aggregation af Ray, Soumya S., Nowak, Richard J., Brown, Robert H., Lansbury, Peter T.

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Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods af Nowak, Richard J., Cuny, Gregory D., Choi, Sungwoon, Lansbury, Peter T., Ray, Soumya S.

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Acceleration of oligomerization, not fibrillization, is a shared property of both α-synuclein mutations linked to early-onset Parkinson's disease: Implications for pathogenesis and... af Conway, Kelly A., Lee, Seung-Jae, Rochet, Jean-Christophe, Ding, Tomas T., Williamson, Robin E., Lansbury, Peter T.

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False negatives in GBA1 sequencing due to polymerase dependent allelic imbalance af den Heijer, Jonas M., Schmitz, Arnoud, Lansbury, Peter, Cullen, Valerie C., Hilt, Dana C., Bonifati, Vincenzo, Groeneveld, Geert Jan

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Membrane-associated farnesylated UCH-L1 promotes α-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease af Liu, Zhihua, Meray, Robin K., Grammatopoulos, Tom N., Fredenburg, Ross A., Cookson, Mark R., Liu, Yichin, Logan, Todd, Lansbury, Peter T.

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Structural basis for conformational plasticity of the Parkinson's disease-associated ubiquitin hydrolase UCH-L1 af Das, Chittaranjan, Hoang, Quyen Q., Kreinbring, Cheryl A., Luchansky, Sarah J., Meray, Robin K., Ray, Soumya S., Lansbury, Peter T., Ringe, Dagmar, Petsko, Gregory A.

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Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein af Paleologou, Katerina E., Schmid, Adrian W., Rospigliosi, Carla C., Kim, Hai-Young, Lamberto, Gonzalo R., Fredenburg, Ross A., Lansbury, Peter T., Fernandez, Claudio O., Eliezer, David, Zweckstetter, Markus, Lashuel, Hilal A.

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Dissociation of amyloid fibrils of α-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities af Foguel, Débora, Suarez, Marisa C., Ferrão-Gonzales, Astria D., Porto, Thais C. R., Palmieri, Leonardo, Einsiedler, Carla M., Andrade, Leonardo R., Lashuel, Hilal A., Lansbury, Peter T., Kelly, Jeffery W., Silva, Jerson L.

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β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site af Zheng, Jianbin, Chen, Long, Skinner, Owen S., Ysselstein, Daniel, Remis, Jonathan, Lansbury, Peter, Skerlj, Renato, Mrosek, Michael, Heunisch, Ursula, Krapp, Stephan, Charrow, Joel, Schwake, Michael, Kelleher, Neil L., Silverman, Richard B., Krainc, Dimitri

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Stress-induced cellular clearance is mediated by SNARE protein ykt6 and disrupted by a-synuclein af Cuddy, Leah K., Wani, Willayat Y., Morella, Martino L., Pitcairn, Caleb, Tsutsumi, Kotaro, Fredriksen, Kristina, Justman, Craig J., Grammatopoulos, Tom N., Belur, Nandkishore R., Zunke, Friederike, Subramanian, Aarthi, Affaneh, Amira, Lansbury, Peter T., Mazzulli, Joseph R.

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Dopamine-modified α-synuclein blocks chaperone-mediated autophagy af Martinez-Vicente, Marta, Talloczy, Zsolt, Kaushik, Susmita, Massey, Ashish C., Mazzulli, Joseph, Mosharov, Eugene V., Hodara, Roberto, Fredenburg, Ross, Wu, Du-Chu, Follenzi, Antonia, Dauer, William, Przedborski, Serge, Ischiropoulos, Harry, Lansbury, Peter T., Sulzer, David, Cuervo, Ana Maria

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Design, Synthesis, and Biological Evaluation of a Series of Oxazolone Carboxamides as a Novel Class of Acid Ceramidase Inhibitors af Caputo, Samantha, Di Martino, Simona, Cilibrasi, Vincenzo, Tardia, Piero, Mazzonna, Marco, Russo, Debora, Penna, Ilaria, Summa, Maria, Bertozzi, Sine Mandrup, Realini, Natalia, Margaroli, Natasha, Migliore, Marco, Ottonello, Giuliana, Liu, Min, Lansbury, Peter, Armirotti, Andrea, Bertorelli, Rosalia, Ray, Soumya S., Skerlj, Renato, Scarpelli, Rita

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A randomized single and multiple ascending dose study in healthy volunteers of LTI‐291, a centrally penetrant glucocerebrosidase activator af den Heijer, Jonas M., Kruithof, Annelieke C., van Amerongen, Guido, de Kam, Marieke L., Thijssen, Eva, Grievink, Hendrika W., Moerland, Matthijs, Walker, Mike, Been, Kees, Skerlj, Renato, Justman, Craig, Dudgeon, Lindsay, Lansbury, Peter, Cullen, Valerie C., Hilt, Dana C., Groeneveld, Geert Jan

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