Hakutulokset - Landles, Christian

Huntingtin and the molecular pathogenesis of Huntington's disease Tekijä Landles, Christian, Bates, Gillian P.

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Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease Tekijä Landles, Christian, Weiss, Andreas, Franklin, Sophie, Howland, David, Bates, Gill

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Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice Tekijä Bryant, Dale T., Landles, Christian, Papadopoulou, Aikaterini S., Benjamin, Agnesska C., Duckworth, Joshua K., Rosahl, Thomas, Benn, Caroline L., Bates, Gillian P.

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The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington’s disease patients Tekijä Neueder, Andreas, Landles, Christian, Ghosh, Rhia, Howland, David, Myers, Richard H., Faull, Richard L. M., Tabrizi, Sarah J., Bates, Gillian P.

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HDAC4 Does Not Act as a Protein Deacetylase in the Postnatal Murine Brain In Vivo Tekijä Mielcarek, Michal, Seredenina, Tamara, Stokes, Matthew P., Osborne, Georgina F., Landles, Christian, Inuabasi, Linda, Franklin, Sophie A., Silva, Jeffrey C., Luthi-Carter, Ruth, Beaumont, Vahri, Bates, Gillian P.

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Correlative light and electron microscopy suggests that mutant huntingtin dysregulates the endolysosomal pathway in presymptomatic Huntington’s disease Tekijä Zhou, Ya, Peskett, Thomas R., Landles, Christian, Warner, John B., Sathasivam, Kirupa, Smith, Edward J., Chen, Shu, Wetzel, Ronald, Lashuel, Hilal A., Bates, Gillian P., Saibil, Helen R.

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Development of novel bioassays to detect soluble and aggregated Huntingtin proteins on three technology platforms Tekijä Landles, Christian, Milton, Rebecca E, Jean, Alexandre, McLarnon, Stuart, McAteer, Sean J, Taxy, Bridget A, Osborne, Georgina F, Zhang, Chuangchuang, Duan, Wenzhen, Howland, David, Bates, Gillian P

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Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease Tekijä Landles, Christian, Sathasivam, Kirupa, Weiss, Andreas, Woodman, Ben, Moffitt, Hilary, Finkbeiner, Steve, Sun, Banghua, Gafni, Juliette, Ellerby, Lisa M., Trottier, Yvon, Richards, William G., Osmand, Alex, Paganetti, Paolo, Bates, Gillian P.

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Mutant huntingtin fragmentation in immune cells tracks Huntington’s disease progression Tekijä Weiss, Andreas, Träger, Ulrike, Wild, Edward J., Grueninger, Stephan, Farmer, Ruth, Landles, Christian, Scahill, Rachael I., Lahiri, Nayana, Haider, Salman, Macdonald, Douglas, Frost, Chris, Bates, Gillian P., Bilbe, Graeme, Kuhn, Rainer, Andre, Ralph, Tabrizi, Sarah J.

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Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease Tekijä Sathasivam, Kirupa, Neueder, Andreas, Gipson, Theresa A., Landles, Christian, Benjamin, Agnesska C., Bondulich, Marie K., Smith, Donna L., Faull, Richard L. M., Roos, Raymund A. C., Howland, David, Detloff, Peter J., Housman, David E., Bates, Gillian P.

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Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene Tekijä Franich, Nicholas R., Hickey, Miriam A., Zhu, Chunni, Osborne, Georgina F., Ali, Nadira, Chu, Tiffany, Bove, Nicholas H., Lemesre, Vincent, Lerner, Renata P., Zeitlin, Scott O., Howland, David, Neueder, Andreas, Landles, Christian, Bates, Gillian P., Chesselet, Marie‐Francoise

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TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models Tekijä Hegde, Ramanath Narayana, Chiki, Anass, Petricca, Lara, Martufi, Paola, Arbez, Nicolas, Mouchiroud, Laurent, Auwerx, Johan, Landles, Christian, Bates, Gillian P, Singh‐Bains, Malvindar K, Dragunow, Mike, Curtis, Maurice A, Faull, Richard LM, Ross, Christopher A, Caricasole, Andrea, Lashuel, Hilal A

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Natural Selection of Human Embryos: Decidualizing Endometrial Stromal Cells Serve as Sensors of Embryo Quality upon Implantation Tekijä Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Brosens, Jan J., Macklon, Nick S.

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Natural Selection of Human Embryos: Impaired Decidualization of Endometrium Disables Embryo-Maternal Interactions and Causes Recurrent Pregnancy Loss Tekijä Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Macklon, Nick S., Brosens, Jan J.

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Subcellular Localization And Formation Of Huntingtin Aggregates Correlates With Symptom Onset And Progression In A Huntington’S Disease Model Tekijä Landles, Christian, Milton, Rebecca E, Ali, Nadira, Flomen, Rachel, Flower, Michael, Schindler, Franziska, Gomez-Paredes, Casandra, Bondulich, Marie K, Osborne, Georgina F, Goodwin, Daniel, Salsbury, Grace, Benn, Caroline L, Sathasivam, Kirupa, Smith, Edward J, Tabrizi, Sarah J, Wanker, Erich E, Bates, Gillian P

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HDAC4 Reduction: A Novel Therapeutic Strategy to Target Cytoplasmic Huntingtin and Ameliorate Neurodegeneration Tekijä Mielcarek, Michal, Landles, Christian, Weiss, Andreas, Bradaia, Amyaouch, Seredenina, Tamara, Inuabasi, Linda, Osborne, Georgina F., Wadel, Kristian, Touller, Chrystelle, Butler, Rachel, Robertson, Janette, Franklin, Sophie A., Smith, Donna L., Park, Larry, Marks, Paul A., Wanker, Erich E., Olson, Eric N., Luthi-Carter, Ruth, van der Putten, Herman, Beaumont, Vahri, Bates, Gillian P.

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A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease Tekijä Björkqvist, Maria, Wild, Edward J., Thiele, Jenny, Silvestroni, Aurelio, Andre, Ralph, Lahiri, Nayana, Raibon, Elsa, Lee, Richard V., Benn, Caroline L., Soulet, Denis, Magnusson, Anna, Woodman, Ben, Landles, Christian, Pouladi, Mahmoud A., Hayden, Michael R., Khalili-Shirazi, Azadeh, Lowdell, Mark W., Brundin, Patrik, Bates, Gillian P., Leavitt, Blair R., Möller, Thomas, Tabrizi, Sarah J.

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