Suchergebnisse - Kristin Beebe

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  1. 1
    Impact of Heat-Shock Protein 90 on Cancer Metastasis

    Impact of Heat-Shock Protein 90 on Cancer Metastasis von Shinji Tsutsumi, Kristin Beebe, Len Neckers

    Veröffentlicht 2009
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  2. 2
    Regulation and function of the human HSP90AA1 gene

    Regulation and function of the human HSP90AA1 gene von Abbey D. Zuehlke, Kristin Beebe, Len Neckers, Thomas L. Prince

    Veröffentlicht 2015
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  3. 3
    Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir

    Selective Inhibition of HER2-Positive Breast Cancer Cells by the HIV Protease Inhibitor Nelfinavir von Joong Sup Shim, Rajini Rao, Kristin Beebe, Len Neckers, Inkyu Han, Rita Nahta, Jun O. Liu

    Veröffentlicht 2012
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  4. 4
    Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90

    Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90 von Byoung Heon Kang, Janet Plescia, Ho Young Song, Massimiliano Meli, Giorgio Colombo, Kristin Beebe, Bradley T. Scroggins, Len Neckers, Dario C. Altieri

    Veröffentlicht 2009
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  5. 5
    Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

    Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation von Ashleigh Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, Milan Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis

    Veröffentlicht 2018
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  6. 6
    The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models

    The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models von Naoto Miyajima, Shinji Tsutsumi, Carole Sourbier, Kristin Beebe, Mehdi Mollapour, Candy Rivas, Soichiro Yoshida, Jane B. Trepel, Ying Huang, Manabu Tatokoro, Nobuo Shinohara, Katsuya Nonomura, Len Neckers

    Veröffentlicht 2013
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  7. 7
    The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition

    The Development of Hsp90β-Selective Inhibitors to Overcome Detriments Associated with <i>pan</i>-Hsp90 Inhibition von Sanket J. Mishra, Weiya Liu, Kristin Beebe, Monimoy Banerjee, Caitlin N. Kent, Vitumbiko Munthali, John Koren, John A. Taylor, Leonard Μ. Neckers, Jeffrey M. Holzbeierlein, Brian S. J. Blagg

    Veröffentlicht 2021
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  8. 8
    An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function

    An Acetylation Site in the Middle Domain of Hsp90 Regulates Chaperone Function von Bradley T. Scroggins, Kenneth Robzyk, Dongxia Wang, Monica G. Marcu, Shinji Tsutsumi, Kristin Beebe, Robert J. Cotter, Sara J. Felts, David O. Toft, Larry M. Karnitz, Neal Rosen, Len Neckers

    Veröffentlicht 2007
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  9. 9
    HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

    HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation von Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzyński, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart K. Calderwood, Len Neckers

    Veröffentlicht 2018
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  10. 10
    Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

    Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1 von Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, Yinying Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Chrisostomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers

    Veröffentlicht 2019
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  11. 11
    Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants

    Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants von Thomas L. Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, Candy Rivas, Sylvia V. Alarcon, Harvey Schwartz, Kofi Khamit-Kush, Bradley T. Scroggins, Kristin Beebe, Jane B. Trepel, Len Neckers

    Veröffentlicht 2015
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  12. 12
    Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine

    Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50CDC37-AHA1 Chaperone Machine von Wanping Xu, Mehdi Mollapour, Chrisostomos Prodromou, Suiquan Wang, Bradley T. Scroggins, Zach Palchick, Kristin Beebe, Marco Siderius, Min-Jung Lee, Anthony D. Couvillon, Jane B. Trepel, Yoshihiko Miyata, Robert L. Matts, Len Neckers

    Veröffentlicht 2012
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  13. 13
    The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

    The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis von Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Grégory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis Tsai, David A. Agard, Len Neckers, Didier Picard

    Veröffentlicht 2020
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  14. 14
    Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity

    Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity von Mehdi Mollapour, Shinji Tsutsumi, Andrew W. Truman, Wanping Xu, Cara K. Vaughan, Kristin Beebe, Anna A Konstantinova, Srinivas Vourganti, Barry Panaretou, Peter W. Piper, Jane B. Trepel, Chrisostomos Prodromou, Laurence H. Pearl, Len Neckers

    Veröffentlicht 2011
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  15. 15
    Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors

    Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors von Kristin Beebe, Mehdi Mollapour, Bradley T. Scroggins, Chrisostomos Prodromou, Wanping Xu, Mari Tokita, Tony Taldone, Lester Pullen, Bettina K. Zierer, Min-Jung Lee, Jane B. Trepel, Johannes Büchner, Daniel N. Bolon, Gabriela Chiosis, Leonard Μ. Neckers

    Veröffentlicht 2013
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  16. 16
    Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target

    Integration of Gene Dosage and Gene Expression in Non-Small Cell Lung Cancer, Identification of HSP90 as Potential Target von Mariëlle I. Gallegos Ruiz, Karijn Floor, Paul Roepman, José Antonio Rodríguez, Gerrit A. Meijer, Wolter J. Mooi, Ewa Jassem, Jacek Nikliński, Thomas Muley, Nico van Zandwijk, Egbert F. Smit, Kristin Beebe, Len Neckers, Bauke Ylstra, Giuseppe Giaccone

    Veröffentlicht 2008
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  17. 17
    Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands

    Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands von Sara Sattin, Jiahui Tao, Gerolamo Vettoretti, Elisabetta Moroni, Marzia Pennati, Alessia Lopergolo, Laura Morelli, Antonella Bugatti, Abbey D. Zuehlke, Mike Moses, Thomas L. Prince, Toshiki Kijima, Kristin Beebe, Marco Rusnati, Len Neckers, Nadia Zaffaroni, David A. Agard, Anna Bernardi, Giorgio Colombo

    Veröffentlicht 2015
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  18. 18
    Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function

    Swe1Wee1-Dependent Tyrosine Phosphorylation of Hsp90 Regulates Distinct Facets of Chaperone Function von Mehdi Mollapour, Shinji Tsutsumi, Alison C. Donnelly, Kristin Beebe, Mari Tokita, Min-Jung Lee, Sunmin Lee, Giulia Morra, Dimitra Bourboulia, Bradley T. Scroggins, Giorgio Colombo, Brian S. J. Blagg, Barry Panaretou, William G. Stetler‐Stevenson, Jane B. Trepel, Peter W. Piper, Chrisostomos Prodromou, Laurence H. Pearl, Len Neckers

    Veröffentlicht 2010
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  19. 19
    Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis

    Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis von Soichiro Yoshida, Shinji Tsutsumi, Guillaume Mühlebach, Carole Sourbier, Min-Jung Lee, Sunmin Lee, Evangelia Vartholomaiou, Manabu Tatokoro, Kristin Beebe, Naoto Miyajima, Robert P. Mohney, Yang Chen, Hisashi Hasumi, Wanping Xu, Hiroshi Fukushima, Ken Nakamura, Fumitaka Koga, Kazunori Kihara, Jane B. Trepel, Didier Picard, Leonard Μ. Neckers

    Veröffentlicht 2013
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  20. 20
    Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

    Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer von Michael A. Moses, Yeong Sang Kim, Génesis M. Rivera-Márquez, Nobu Oshima, Matthew J. Watson, Kristin Beebe, Catherine Wells, Sunmin Lee, Abbey D. Zuehlke, Hao Shao, William E. Bingman, Vineet Kumar, Sanjay V. Malhotra, Nancy L. Weigel, Jason E. Gestwicki, Jane B. Trepel, Leonard Μ. Neckers

    Veröffentlicht 2018
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