检索结果 - Koole, Cassandra

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation 由 Koole, Cassandra, Wootten, Denise, Simms, John, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.

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Minireview: Signal Bias, Allosterism, and Polymorphic Variation at the GLP-1R: Implications for Drug Discovery 由 Koole, Cassandra, Savage, Emilia E., Christopoulos, Arthur, Miller, Laurence J., Sexton, Patrick M., Wootten, Denise

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Polymorphism and Ligand Dependent Changes in Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Function: Allosteric Rescue of Loss of Function Mutation 由 Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.

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Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP... 由 Koole, Cassandra, Reynolds, Christopher A., Mobarec, Juan C., Hick, Caroline, Sexton, Patrick M., Sakmar, Thomas P.

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Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function 由 Koole, Cassandra, Wootten, Denise, Simms, John, Savage, Emilia E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.

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Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications f... 由 Koole, Cassandra, Wootten, Denise, Simms, John, Valant, Celine, Sridhar, Rohan, Woodman, Owen L., Miller, Laurence J., Summers, Roger J., Christopoulos, Arthur, Sexton, Patrick M.

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Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery 由 Harikumar, Kaleeckal G., Wootten, Denise, Pinon, Delia I., Koole, Cassandra, Ball, Alicja M., Furness, Sebastian G. B., Graham, Bim, Dong, Maoqing, Christopoulos, Arthur, Miller, Laurence J., Sexton, Patrick M.

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A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures 由 Wootten, Denise, Reynolds, Christopher A., Koole, Cassandra, Smith, Kevin J., Mobarec, Juan C., Simms, John, Quon, Tezz, Coudrat, Thomas, Furness, Sebastian G. B., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.

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Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism 由 Lei, Saifei, Clydesdale, Lachlan, Dai, Antao, Cai, Xiaoqing, Feng, Yang, Yang, Dehua, Liang, Yi-Lynn, Koole, Cassandra, Zhao, Peishen, Coudrat, Thomas, Christopoulos, Arthur, Wang, Ming-Wei, Wootten, Denise, Sexton, Patrick M.

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O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity 由 Levine, Paul M., Balana, Aaron T., Sturchler, Emmanuel, Koole, Cassandra, Noda, Hiroshi, Zarzycka, Barbara, Daley, Eileen J., Truong, Tin T., Katritch, Vsevolod, Gardella, Thomas J., Wootten, Denise, Sexton, Patrick M., McDonald, Patricia, Pratt, Matthew R.

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Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor 由 Liang, Yi-Lynn, Khoshouei, Maryam, Deganutti, Giuseppe, Glukhova, Alisa, Koole, Cassandra, Peat, Thomas S., Radjainia, Mazdak, Plitzko, Jürgen M., Baumeister, Wolfgang, Miller, Laurence J., Hay, Deborah L., Christopoulos, Arthur, Reynolds, Christopher A, Wootten, Denise, Sexton, Patrick M.

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism 由 Wootten, Denise, Reynolds, Christopher A., Smith, Kevin J., Mobarec, Juan C., Koole, Cassandra, Savage, Emilia E., Pabreja, Kavita, Simms, John, Sridhar, Rohan, Furness, Sebastian G.B., Liu, Mengjie, Thompson, Philip E., Miller, Laurence J., Christopoulos, Arthur, Sexton, Patrick M.

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Structure and Dynamics of Adrenomedullin Receptors AM(1) and AM(2) Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins 由 Liang, Yi-Lynn, Belousoff, Matthew J., Fletcher, Madeleine M., Zhang, Xin, Khoshouei, Maryam, Deganutti, Giuseppe, Koole, Cassandra, Furness, Sebastian G. B., Miller, Laurence J., Hay, Debbie L., Christopoulos, Arthur, Reynolds, Christopher A., Danev, Radostin, Wootten, Denise, Sexton, Patrick M.

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