檢索結果 - Kennan C. Marsh

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  1. 1
    Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans

    Enhancement of the in vitro and in vivo activities of clarithromycin against Haemophilus influenzae by 14-hydroxy-clarithromycin, its major metabolite in humans 由 Dwight J. Hardy, R. N. Swanson, Richard A. Rode, Kennan C. Marsh, N. L. Shipkowitz, Jacob J. Clement

    出版 1990
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  2. 2
    Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease

    Antiviral and pharmacokinetic properties of C2 symmetric inhibitors of the human immunodeficiency virus type 1 protease 由 Dale J. Kempf, Kennan C. Marsh, Deborah A. Paul, Mark F. Knigge, Daniel W. Norbeck, W E Kohlbrenner, L Codacovi, Sudthida Vasavanonda, P Bryant, X C Wang

    出版 1991
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  3. 3
    ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.

    ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans. 由 Dale J. Kempf, Kennan C. Marsh, Jon F. Denissen, Edith McDonald, Sudthida Vasavanonda, Charles A. Flentge, B E Green, Lynnmarie Codacovi Fino, C H Park, X.P. Kong

    出版 1995
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  4. 4
    Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir

    Pharmacokinetic enhancement of inhibitors of the human immunodeficiency virus protease by coadministration with ritonavir 由 Dale J. Kempf, Kennan C. Marsh, Gondi Kumar, A. David Rodrigues, Jon F. Denissen, Edith McDonald, Michael Kukulka, Ann Hsu, G. Richard Granneman, Paolo Baroldi, Eugene Sun, David Pizzuti, J. J. PLATTNER, Daniel W. Norbeck, John M. Leonard

    出版 1997
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  5. 5
    Activation of dopamine D <sub>4</sub> receptors by ABT-724 induces penile erection in rats

    Activation of dopamine D <sub>4</sub> receptors by ABT-724 induces penile erection in rats 由 Jorge D. Brioni, Robert B. Moreland, Marlon Cowart, Gin C. Hsieh, Andrew O. Stewart, Petter Hedlund, Diana L. Donnelly‐Roberts, Masaki Nakane, James J. Lynch, Teodozyi Kolasa, James S. Polakowski, Mark A. Osinski, Kennan C. Marsh, Karl‐Erik Andersson, James P. Sullivan

    出版 2004
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  6. 6
    Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study

    Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: a two-part first-in-human phase 1a/1b randomised study 由 James McCarthy, Julie Lotharius, Thomas Rückle, Stephan Chalon, Margaret A. Phillips, Suzanne Elliott, Silvana Sekuloski, Paul Griffin, Caroline L. Ng, David A. Fidock, Louise Marquart, Noelle S. Williams, Nathalie Gobeau, Lidiya Bebrevska, Maria Rosario, Kennan C. Marsh, Jörg J. Möhrle

    出版 2017
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  7. 7
    ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

    ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor 由 Christin Tse, Alexander R. Shoemaker, Jessica Adickes, Mark G. Anderson, Jun Chen, Sha Jin, Eric F. Johnson, Kennan C. Marsh, Michael J. Mitten, Paul Nimmer, Lisa Roberts, Stephen K. Tahir, Xiao Yu, Xiufen Yang, Haichao Zhang, Stephen W. Fesik, Saul H. Rosenberg, Steven W. Elmore

    出版 2008
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  8. 8
    TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists

    TRPV1 Receptors in the CNS Play a Key Role in Broad-Spectrum Analgesia of TRPV1 Antagonists 由 Minghua Cui, Prisca Honoré, Chengmin Zhong, Donna M. Gauvin, Joseph P. Mikusa, Gricelda Hernandez, Prem K.G. Chandran, Arthur Gomtsyan, Brian S. Brown, Erol K. Bayburt, Kennan C. Marsh, B. Bianchi, Heath A. McDonald, Wende Niforatos, Torben R. Neelands, Robert B. Moreland, M. W. Decker, Celeste Lee, James P. Sullivan, Connie R. Faltynek

    出版 2006
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  9. 9
    Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways

    Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways 由 Robert S. Bitner, William H. Bunnelle, David J. Anderson, Clark A. Briggs, Jerry J. Buccafusco, Peter Curzon, Michael Decker, Jennifer M. Frost, Jens Halvard Grønlien, Earl J. Gubbins, Jinhe Li, John Malysz, Stella Markosyan, Kennan C. Marsh, Michael D. Meyer, Arthur L. Nikkel, Richard J. Radek, Holly M. Robb, Daniel B. Timmermann, James P. Sullivan, Murali Gopalakrishnan

    出版 2007
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  10. 10
    ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease

    ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease 由 Hing L. Sham, Dale J. Kempf, Akhteruzammen Molla, Kennan C. Marsh, Gondi Kumar, Chih‐Ming Chen, Warren M. Kati, Kent D. Stewart, Ritu Lal, Ann Hsu, David A. Betebenner, Marina Korneyeva, Sudthida Vasavanonda, Edith McDonald, Ayda Saldivar, Norm Wideburg, Xiaoqi Chen, Ping Niu, Chang Park, Venkata Jayanti, Brian Grabowski, G. Richard Granneman, Eugene Sun, Anthony J. Japour, John M. Leonard, Jacob J. Plattner, Daniel W. Norbeck

    出版 1998
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  11. 11
    A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs<i>In vitro</i>and<i>In vivo</i>

    A Small-Molecule Inhibitor of Bcl-XL Potentiates the Activity of Cytotoxic Drugs<i>In vitro</i>and<i>In vivo</i> 由 Alex R. Shoemaker, Anatol Oleksijew, Joy Bauch, Barbara Belli, Tony Borre, Milan Bruncko, Thomas Deckwirth, David J. Frost, Ken Jarvis, Mary K. Joseph, Kennan C. Marsh, William J. McClellan, Hugh N. Nellans, ShiChung Ng, Paul Nimmer, Jacqueline M. O’Connor, Tilman Oltersdorf, Weiguo Qing, Shen Wang, Jason Stavropoulos, Stephen K. Tahir, Baole Wang, Robert B. Warner, Haichao Zhang, Stephen W. Fesik, Saul H. Rosenberg, Steven W. Elmore

    出版 2006
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  12. 12
    Development of an Orally Available and Central Nervous System (CNS) Penetrant <i>Toxoplasma gondii</i> Calcium-Dependent Protein Kinase 1 (<i>Tg</i>CDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of <i>Toxoplasmosis</i>

    Development of an Orally Available and Central Nervous System (CNS) Penetrant <i>Toxoplasma gondii</i> Calcium-Dependent Protein Kinase 1 (<i>Tg</i>CDPK1) Inhibitor with Minimal Hu... 由 Rama Subba Rao Vidadala, Kasey Rivas, Kayode K. Ojo, Matthew A. Hulverson, Jennifer A. Zambriski, Igor Bruzual, Tracey L. Schultz, Wenlin Huang, Zhongsheng Zhang, Suzanne Scheele, Amy E. DeRocher, Ryan Choi, Lynn K. Barrett, Latha Kallur Siddaramaiah, Wim G. J. Hol, Erkang Fan, E.A. Merritt, Marilyn Parsons, Gail Freiberg, Kennan C. Marsh, Dale J. Kempf, Vern B. Carruthers, Nina Isoherranen, J. Stone Doggett, Wesley C. Van Voorhis, Dustin J. Maly

    出版 2016
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  13. 13
    Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned

    Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned 由 Ryan Choi, Matthew A. Hulverson, Wenlin Huang, Rama Subba Rao Vidadala, Grant R. Whitman, Lynn K. Barrett, Deborah A. Schaefer, Dana P. Betzer, Michael W. Riggs, J. Stone Doggett, Andrew Hemphill, Luís Miguel Ortega-Mora, Molly C. McCloskey, Samuel L.M. Arnold, Robert C. Hackman, Kennan C. Marsh, James J. Lynch, Gail M. Freiberg, Bruce E. LeRoy, Dale J. Kempf, Robert K. M. Choy, Eugenio L. de Hostos, Dustin J. Maly, Erkang Fan, Kayode K. Ojo, Wesley C. Van Voorhis

    出版 2020
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  14. 14
    Preclinical development of an oral anti- <i>Wolbachia</i> macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

    Preclinical development of an oral anti- <i>Wolbachia</i> macrolide drug for the treatment of lymphatic filariasis and onchocerciasis 由 Mark J. Taylor, Thomas W von Geldern, Louise Ford, Marc P. Hübner, Kennan C. Marsh, Kelly L. Johnston, Hanna Sjoberg, Sabine Specht, Nicolas Pionnier, Hayley E. Tyrer, Rachel H. Clare, Darren A. N. Cook, Emma Murphy, Andrew Steven, John Archer, Dominique Bloemker, Franziska Lenz, Marianne Koschel, Alexandra Ehrens, Haelly Metuge, Valerinne C. Chunda, Patrick W. N. Chounna, Abdel Jélil Njouendou, Fanny Fri Fombad, Robert A. Carr, Howard E. Morton, Ghaith Aljayyoussi, Achim Hoerauf, Samuel Wanji, Dale J. Kempf, Joseph D. Turner, Stephen A. Ward

    出版 2019
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  15. 15
    A-803467, a potent and selective Na <sub>v</sub> 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat

    A-803467, a potent and selective Na <sub>v</sub> 1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat 由 Michael F. Jarvis, Prisca Honoré, Char‐Chang Shieh, Mark L. Chapman, Shailen K. Joshi, Xu-Feng Zhang, Michael E. Kort, William Carroll, Brian E. Marron, Robert N. Atkinson, James B. Thomas, Dong Liu, Michael J. Krambis, Yi Liu, Steve McGaraughty, Katharine L. Chu, Rosemarie Roeloffs, Chengmin Zhong, Joseph P. Mikusa, Gricelda Hernandez, Donna M. Gauvin, Carrie L. Wade, Chang Zhu, Madhavi Pai, Marc J. C. Scanio, Lei Shi, Irene Drizin, Robert J. Gregg, Mark A. Matulenko, Ahmed H. Hakeem, Michael F. Gross, Matthew S. Johnson, Kennan C. Marsh, P. Kay Wagoner, James P. Sullivan, Connie R. Faltynek, Douglas S. Krafte

    出版 2007
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  16. 16
    Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties

    Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties 由 Karin Tietje, David J. Anderson, Robert S. Bitner, Eric A.G. Blomme, Paul J. Brackemeyer, Clark A. Briggs, Kaitlin E. Browman, Dagmar Bury, Peter Curzon, Karla Drescher, Jennifer M. Frost, Ryan M. Fryer, Gerard B. Fox, Jens Halvard Grønlien, Monika Håkerud, Earl J. Gubbins, Sabine Halm, Richard Harris, Rosalind Helfrich, Kathy L. Kohlhaas, Devalina Law, John Malysz, Kennan C. Marsh, Ruth L. Martin, Michael D. Meyer, Angela L. Molesky, Arthur L. Nikkel, Stephani Otte, Liping Pan, Pamela S. Puttfarcken, Richard J. Radek, Holly M. Robb, Eva Spies, Kirsten Thorin‐Hagene, Jeffrey F. Waring, Hilde Ween, Hongyu Xu, Murali Gopalakrishnan, William H. Bunnelle

    出版 2008
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  17. 17
    ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models

    ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models 由 Cherrie K. Donawho, Yan Luo, Yanping Luo, Thomas D. Penning, Joy Bauch, Jennifer J. Bouska, Velitchka Bontcheva-Diaz, Bryan F. Cox, Theodore L. DeWeese, Larry E. Dillehay, Debra C. Ferguson, Nayereh Ghoreishi‐Haack, David R. Grimm, Ran Guan, Edward K. Han, Rhonda R. Holley-Shanks, Boris Hristov, Kenneth B. Idler, Ken Jarvis, Eric F. Johnson, Lawrence Kleinberg, Vered Klinghofer, Loren Lasko, Xuesong Liu, Kennan C. Marsh, Thomas McGonigal, Jonathan A. Meulbroek, Amanda M. Olson, Joann P. Palma, Luis E. Rodrı́guez, Yan Shi, Jason Stavropoulos, Alan C. Tsurutani, Gui‐Dong Zhu, Saul H. Rosenberg, Vincent L. Giranda, David J. Frost

    出版 2007
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  18. 18
    A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

    A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria 由 Margaret A. Phillips, Karen L. White, Sreekanth Kokkonda, Xiaoyi Deng, John White, Farah El Mazouni, Kennan C. Marsh, D.R. Tomchick, Krishne Manjalanagara, Kakali Rani Rudra, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, David M. Shackleford, Francis C. K. Chiu, Michael G. Campbell, Marı́a Belén Jiménez-Dı́az, Santiago Ferrer, Íñigo Angulo‐Barturen, María Santos Martínez, María José Lafuente-Monasterio, Werner Kaminsky, Kigbafori D. Silué, Anne‐Marie Zeeman, Clemens H. M. Kocken, Didier Leroy, Benjamin Blasco, Emilie Rossignol, Thomas Rueckle, Dave Matthews, Jeremy N. Burrows, David Waterson, Michael Palmer, Pradipsinh K. Rathod, Susan A. Charman

    出版 2016
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  19. 19
    Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

    Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties 由 Karin Tietje, David J. Anderson, Robert S. Bitner, Eric A.G. Blomme, Paul J. Brackemeyer, Clark A. Briggs, Kaitlin E. Browman, Dagmar Bury, Peter Curzon, Karla Drescher, Jennifer M. Frost, Ryan M. Fryer, Gerard B. Fox, Jens Halvard Grønlien, Monika Håkerud, Earl J. Gubbins, Sabine Halm, Richard Harris, Rosalind Helfrich, Kathy L. Kohlhaas, Devalina Law, John Malysz, Kennan C. Marsh, Ruth L. Martin, Michael D. Meyer, Angela L. Molesky, Arthur L. Nikkel, Stephani Otte, Liping Pan, Pamela S. Puttfarcken, Richard J. Radek, Holly M. Robb, Eva Spies, Kirsten Thorin‐Hagene, Jeffrey F. Waring, Hilde Ween, Hongyu Xu, Murali Gopalakrishnan, William H. Bunnelle

    出版 2008
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  20. 20
    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria 由 Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Gregory S. Basarab, Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Aloysius T. Nchinda, Carmen De Kock, Lubbe Wiesner, Paolo Denti, David Waterson, Benjamin Blasco, Didier Leroy, Michael J. Witty, Cristina Donini, James Duffy, Sergio Wittlin, Karen L. White, Susan A. Charman, Marı́a Belén Jiménez-Dı́az, Íñigo Angulo‐Barturen, Esperanza Herreros, Francisco‐Javier Gamo, Rosemary Rochford, Dalu Mancama, Thérèsa L. Coetzer, Mariëtte van der Watt, Janette Reader, Lyn‐Marié Birkholtz, Kennan C. Marsh, Suresh Solapure, John E. Burke, Jacob A. McPhail, Manu Vanaerschot, David A. Fidock, Paul V. Fish, Peter K. S. Siegl, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Kigbafori D. Silué, Leslie J. Street, Kelly Chibale

    出版 2018
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