Canlyniadau Chwilio - Karen A. Kirby

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  1. 1
    Avoiding Drug Resistance in HIV Reverse Transcriptase

    Avoiding Drug Resistance in HIV Reverse Transcriptase gan Maria E. Cilento, Karen A. Kirby, Stefan G. Sarafianos

    Cyhoeddwyd 2021
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  2. 2
    Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase

    Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase gan Kamalendra Singh, Bruno Marchand, Karen A. Kirby, Eleftherios Michailidis, Stefan G. Sarafianos

    Cyhoeddwyd 2010
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  3. 3
    X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability

    X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability gan A.T. Gres, Karen A. Kirby, Vineet N. KewalRamani, John J. Tanner, Owen Pornillos, Stefan G. Sarafianos

    Cyhoeddwyd 2015
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  4. 4
    Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H

    Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2,4-diones as inhibitors of HIV reverse transcriptase-associated RNase H gan Jayakanth Kankanala, Karen A. Kirby, Andrew D. Huber, Mary C. Casey, Daniel J. Wilson, Stefan G. Sarafianos, Zhengqiang Wang

    Cyhoeddwyd 2017
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  5. 5
    Rotten to the core: antivirals targeting the HIV-1 capsid core

    Rotten to the core: antivirals targeting the HIV-1 capsid core gan William M. McFadden, Alexa A. Snyder, Karen A. Kirby, Philip R. Tedbury, Monika Raj, Zhengqiang Wang, Stefan G. Sarafianos

    Cyhoeddwyd 2021
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  6. 6
    Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H

    Design, Synthesis, and Biological Evaluations of Hydroxypyridonecarboxylic Acids as Inhibitors of HIV Reverse Transcriptase Associated RNase H gan Jayakanth Kankanala, Karen A. Kirby, Feng Liu, Lena Miller, Éva Nagy, Daniel J. Wilson, Michael A. Parniak, Stefan G. Sarafianos, Zhengqiang Wang

    Cyhoeddwyd 2016
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  7. 7
    3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations

    3-Hydroxypyrimidine-2,4-diones as Selective Active Site Inhibitors of HIV Reverse Transcriptase-Associated RNase H: Design, Synthesis, and Biochemical Evaluations gan Jing Tang, Feng Liu, Éva Nagy, Lena Miller, Karen A. Kirby, Daniel J. Wilson, Bulan Wu, Stefan G. Sarafianos, Michael A. Parniak, Zhengqiang Wang

    Cyhoeddwyd 2016
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  8. 8
    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA)

    Structural basis of HIV inhibition by translocation-defective RT inhibitor 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) gan Zhe Salie, Karen A. Kirby, Eleftherios Michailidis, Bruno Marchand, Kamalendra Singh, Lisa C. Rohan, Eiichi Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos

    Cyhoeddwyd 2016
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  9. 9
    Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transcriptase-Associated RNase H and Polymerase with Antiviral Activities

    Design, Synthesis, Biochemical, and Antiviral Evaluations of C6 Benzyl and C6 Biarylmethyl Substituted 2-Hydroxylisoquinoline-1,3-diones: Dual Inhibition against HIV Reverse Transc... gan Sanjeev Kumar V. Vernekar, Zheng Liu, Éva Nagy, Lena Miller, Karen A. Kirby, Daniel J. Wilson, Jayakanth Kankanala, Stefan G. Sarafianos, Michael A. Parniak, Zhengqiang Wang

    Cyhoeddwyd 2014
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  10. 10
    Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2

    Small Molecule Inhibitor that Stabilizes the Autoinhibited Conformation of the Oncogenic Tyrosine Phosphatase SHP2 gan Xiaoqin Wu, Gang Xu, Xiaobo Li, Weiren Xu, Qianjin Li, Wei Liu, Karen A. Kirby, Mignon L. Loh, Jun Li, Stefan G. Sarafianos, Cheng‐Kui Qu

    Cyhoeddwyd 2018
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  11. 11
    Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

    Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor gan Eleftherios Michailidis, Bruno Marchand, Eiichi Kodama, Kamlendra Singh, Masao Matsuoka, Karen A. Kirby, Emily Ryan, Ali M. Sawani, Éva Nagy, Noriyuki Ashida, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos

    Cyhoeddwyd 2009
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  12. 12
    Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity

    Double-Winged 3-Hydroxypyrimidine-2,4-diones: Potent and Selective Inhibition against HIV-1 RNase H with Significant Antiviral Activity gan Sanjeev Kumar V. Vernekar, Jing Tang, Bulan Wu, Andrew D. Huber, Mary C. Casey, Nataliya Myshakina, Daniel J. Wilson, Jayakanth Kankanala, Karen A. Kirby, Michael A. Parniak, Stefan G. Sarafianos, Zhengqiang Wang

    Cyhoeddwyd 2017
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  13. 13
    Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase

    Baicalein and Baicalin Inhibit SARS-CoV-2 RNA-Dependent-RNA Polymerase gan Keivan Zandi, Katie Musall, Adrian Oo, Dongdong Cao, Bo Liang, Pouya Hassandarvish, Shuiyun Lan, Ryan L. Slack, Karen A. Kirby, Leda Bassit, Franck Amblard, Baek Kim, Sazaly AbuBakar, Stefan G. Sarafianos, Raymond F. Schinazi

    Cyhoeddwyd 2021
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  14. 14
    4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms

    4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) Inhibits HIV-1 Reverse Transcriptase with Multiple Mechanisms gan Eleftherios Michailidis, Andrew D. Huber, Emily Ryan, Yee Tsuey Ong, Maxwell D. Leslie, Kayla B. Matzek, Kamalendra Singh, Bruno Marchand, Ariel N. Hagedorn, Karen A. Kirby, Lisa C. Rohan, Eiichi Kodama, Hiroaki Mitsuya, Michael A. Parniak, Stefan G. Sarafianos

    Cyhoeddwyd 2014
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  15. 15
    Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease

    Strategy to overcome a nirmatrelvir resistance mechanism in the SARS-CoV-2 nsp5 protease gan Grace Neilsen, Shuiyun Lan, Ryan L. Slack, Zachary C. Lorson, Andres Emanuelli Castaner, Rachel Lee, Kristin Edwards, Huanchun Zhang, Jasper Lee, William A. Cantara, Maria E. Cilento, Hongwang Zhang, Ramyani De, Franck Amblard, Philip R. Tedbury, Karen A. Kirby, Raymond F. Schinazi, Stefan G. Sarafianos

    Cyhoeddwyd 2025
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  16. 16
    Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition

    Identification of clickable HIV-1 capsid-targeting probes for viral replication inhibition gan William M. McFadden, Mary C. Casey, Grant A. L. Bare, Karen A. Kirby, Xin Wen, Gencheng Li, Hua Wang, Ryan L. Slack, Alexa A. Snyder, Zachary C. Lorson, Isabella L. Kaufman, Maria E. Cilento, Philip R. Tedbury, Milan Gembický, Arthur J. Olson, Bruce E. Torbett, K. Barry Sharpless, Stefan G. Sarafianos

    Cyhoeddwyd 2024
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