Search Results - Kallanthottathil G. Rajeev

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  1. 1
    Specificity, duplex degradation and subcellular localization of antagomirs

    Specificity, duplex degradation and subcellular localization of antagomirs by Jan Krützfeldt, Satoru Kuwajima, Ravi Braich, Kallanthottathil G. Rajeev, John Pena, Thomas Tuschl, Muthiah Manoharan, Markus Stoffel

    Published 2007
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  2. 2
    Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA

    Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA by Md. Rowshon Alam, Xin Ming, Michael H. Fisher, Jeremy G. Lackey, Kallanthottathil G. Rajeev, Muthiah Manoharan, R. L. Juliano

    Published 2011
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  3. 3
    Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

    Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates by Donald J. Foster, Christopher R. Brown, Sarfraz Shaikh, Casey Trapp, Mark K. Schlegel, Kun Qian, Alfica Sehgal, Kallanthottathil G. Rajeev, Vasant Jadhav, Muthiah Manoharan, Satya Kuchimanchi, Martin A. Maier, Stuart Milstein

    Published 2018
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  4. 4
    Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs

    Unique Gene‐Silencing and Structural Properties of 2′‐Fluoro‐Modified siRNAs by Muthiah Manoharan, Akin Akinc, Rajendra K. Pandey, June Qin, Philipp Hadwiger, Matthias John, Kathy Mills, Klaus Charissé, Martin A. Maier, Lubomir V. Nechev, Emily M. Greene, Pradeep S. Pallan, Eriks Rozners, Kallanthottathil G. Rajeev, Martin Egli

    Published 2011
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  5. 5
    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides

    Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5′-<i>C</i>-Methyl Pyrimidine-Modified Oligonucleotides by Alexander V. Kel’in, Ivan Zlatev, Joel M. Harp, Muthusamy Jayaraman, Anna Bisbe, Jonathan O′Shea, Nate Taneja, Rajar M. Manoharan, Saeed I. Khan, Klaus Charissé, Martin A. Maier, Martin Egli, Kallanthottathil G. Rajeev, Muthiah Manoharan

    Published 2016
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  6. 6
    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver

    Development of Lipidoid–siRNA Formulations for Systemic Delivery to the Liver by Akin Akinc, Michael S. Goldberg, June Qin, J. Robert Dorkin, Christina Gamba‐Vitalo, Martin A. Maier, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, Muthiah Manoharan, Victor Koteliansky, Ingo Röhl, Elizaveta S. Leshchiner, Róbert Langer, Daniel G. Anderson

    Published 2009
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  7. 7
    Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits

    Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits by Marian DiFiglia, Miguel Sena‐Esteves, Kathryn Chase, Ellen Sapp, E. Pfister, Magdolna Sass, Jeffrey A. Yoder, Patrick Reeves, Raj Kumar Pandey, Kallanthottathil G. Rajeev, Muthiah Manoharan, Dinah W.Y. Sah, Phillip D. Zamore, Neil Aronin

    Published 2007
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  8. 8
    Modulation of thermal stability can enhance the potency of siRNA

    Modulation of thermal stability can enhance the potency of siRNA by Haripriya Addepalli, Meena Meena, Chang G. Peng, Guanghui Wang, Yi Fan, Klaus Charissé, K. N. Jayaprakash, Kallanthottathil G. Rajeev, Raj Kumar Pandey, Gary Lavine, Lei Zhang, Kerstin Jahn‐Hofmann, Philipp Hadwiger, Muthiah Manoharan, Martin A. Maier

    Published 2010
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  9. 9
    A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo

    A Glu-urea-Lys Ligand-conjugated Lipid Nanoparticle/siRNA System Inhibits Androgen Receptor Expression In Vivo by Justin B. Lee, Kaixin Zhang, Yuen Yi C. Tam, Joslyn Quick, Ying K. Tam, Paulo J.C. Lin, Sam Chen, Yan Liu, Jayaprakash K. Nair, Ivan Zlatev, Kallanthottathil G. Rajeev, Muthiah Manoharan, Paul S. Rennie, Pieter R. Cullis

    Published 2016
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  10. 10
    Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

    Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity by Maja M. Janas, Mark K. Schlegel, Carole E. Harbison, Vedat O. Yilmaz, Yongfeng Jiang, Rubina Parmar, Ivan Zlatev, Adam Castoreno, Huilei Xu, Svetlana Shulga‐Morskaya, Kallanthottathil G. Rajeev, Muthiah Manoharan, Natalie Keirstead, Martin A. Maier, Vasant Jadhav

    Published 2018
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  11. 11
    Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology <i>in vivo</i>

    Chirality matters: stereo-defined phosphorothioate linkages at the termini of small interfering RNAs improve pharmacology <i>in vivo</i> by Hartmut Jahns, Nate Taneja, Jennifer L. S. Willoughby, Masaaki Akabane‐Nakata, Christopher R. Brown, Tuyen Nguyen, Anna Bisbe, Shigeo Matsuda, Matt Hettinger, Rajar M. Manoharan, Kallanthottathil G. Rajeev, Martin A. Maier, Ivan Zlatev, Klaus Charissé, Martin Egli, Muthiah Manoharan

    Published 2021
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  12. 12
    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

    Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression by Jennifer L. S. Willoughby, Amy Chan, Alfica Sehgal, James S. Butler, Jayaprakash K. Nair, Tim Racie, Svetlana Shulga‐Morskaya, Tuyen Nguyen, Kun Qian, Kristina Yucius, Klaus Charissé, Theo J.C. van Berkel, Muthiah Manoharan, Kallanthottathil G. Rajeev, Martin A. Maier, Vasant Jadhav, Tracy Zimmermann

    Published 2017
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  13. 13
    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles

    Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles by Barbara L. Mui, Ying K. Tam, Muthusamy Jayaraman, Steven M. Ansell, Xinyao Du, Yuen Yi C. Tam, Paulo J.C. Lin, Sam Chen, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Muthiah Manoharan, Akin Akinc, Martin A. Maier, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope

    Published 2013
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  14. 14
    GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy

    GalNAc-Lipid nanoparticles enable non-LDLR dependent hepatic delivery of a CRISPR base editing therapy by Lisa N. Kasiewicz, Souvik Biswas, Aaron Beach, Huilan Ren, Chaitali Dutta, Anne Marie Mazzola, Ellen Rohde, Alexandra C. Chadwick, Christopher H.K. Cheng, Sara P. Garcia, Sowmya Iyer, Yuri Matsumoto, Amit V. Khera, Kiran Musunuru, Sekar Kathiresan, Padma Malyala, Kallanthottathil G. Rajeev, Andrew M. Bellinger

    Published 2023
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  15. 15
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** by Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    Published 2012
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  16. 16
    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

    Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo** by Muthusamy Jayaraman, Steven M. Ansell, Barbara L. Mui, Ying K. Tam, Jianxin Chen, Xinyao Du, David Butler, Laxman Eltepu, Shigeo Matsuda, Jayaprakash K. Narayanannair, Kallanthottathil G. Rajeev, Ismail M. Hafez, Akin Akinc, Martin A. Maier, Mark A. Tracy, Pieter R. Cullis, Thomas D. Madden, Muthiah Manoharan, Michael J. Hope

    Published 2012
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  17. 17
    Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis

    Preclinical evaluation of RNAi as a treatment for transthyretin-mediated amyloidosis by James S. Butler, Amy Chan, Susete Costelha, Shannon Fishman, Jennifer L. S. Willoughby, Todd Borland, Stuart Milstein, Donald J. Foster, Paula Gonçalves, Qingmin Chen, June Qin, Brian R. Bettencourt, Dinah W.Y. Sah, Rene Alvarez, Kallanthottathil G. Rajeev, Muthiah Manoharan, Kevin Fitzgerald, Rachel Meyers, Saraswathy V. Nochur, Maria João Saraiva, Tracy Zimmermann

    Published 2016
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  18. 18
    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates

    Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates by Jayaprakash K. Nair, Husain Attarwala, Alfica Sehgal, Qianfan Wang, Krishna Aluri, Xuemei Zhang, Minggeng Gao, Ju Liu, Ramesh Indrakanti, Sally Schofield, Philip Kretschmer, Christopher R. Brown, Swati Gupta, Jennifer L. S. Willoughby, Julie A. Boshar, Vasant Jadhav, Klaus Charissé, Tracy Zimmermann, Kevin Fitzgerald, Muthiah Manoharan, Kallanthottathil G. Rajeev, Akin Akinc, Renta Hutabarat, Martin A. Maier

    Published 2017
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  19. 19
    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

    Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms by Akin Akinc, William Querbes, Soma De, June Qin, Maria Frank-Kamenetsky, K. N. Jayaprakash, Muthusamy Jayaraman, Kallanthottathil G. Rajeev, William Cantley, J. Robert Dorkin, James S. Butler, LiuLiang Qin, Timothy Racie, Andrew Sprague, Eugenio Fava, Anja Zeigerer, Michael J. Hope, Marino Zerial, Dinah W.Y. Sah, Kevin Fitzgerald, Mark A. Tracy, Muthiah Manoharan, Victor Koteliansky, Antonin de Fougerolles, Martin A. Maier

    Published 2010
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  20. 20
    Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

    Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics by Martin A. Maier, Muthusamy Jayaraman, Shigeo Matsuda, Ju Liu, Scott Barros, William Querbes, Ying K. Tam, Steven M. Ansell, Varun Kumar, June Qin, Xuemei Zhang, Qianfan Wang, Sue Panesar, Renta Hutabarat, Mary Carioto, Julia Hettinger, Kandasamy Pachamuthu, David Butler, Kallanthottathil G. Rajeev, Bo Pang, Klaus Charissé, Kevin Fitzgerald, Barbara L. Mui, Xinyao Du, Pieter R. Cullis, Thomas D. Madden, Michael J. Hope, Muthiah Manoharan, Akin Akinc

    Published 2013
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