Ohcanbohtosat - Jousma, Edwin

An inflammatory gene signature distinguishes neurofibroma Schwann cells and macrophages from cells in the normal peripheral nervous system Dahkki Choi, Kwangmin, Komurov, Kakajan, Fletcher, Jonathan S., Jousma, Edwin, Cancelas, Jose A., Wu, Jianqiang, Ratner, Nancy

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STAT3 inhibition reduces macrophage number and tumor growth in neurofibroma Dahkki Fletcher, Jonathan S., Springer, Mitchell G., Choi, Kwangmin, Jousma, Edwin, Rizvi, Tilat A., Dombi, Eva, Kim, Mi-Ok, Wu, Jianqiang, Ratner, Nancy

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Preclinical assessments of the MEK inhibitor PD-0325901 in a mouse model of neurofibromatosis type 1 Dahkki Jousma, Edwin, Rizvi, Tilat A., Wu, Jianqiang, Janhofer, David, Dombi, Eva, Dunn, Richard S., Kim, Mi-Ok, Masters, Andrea R., Jones, David R., Cripe, Timothy P., Ratner, Nancy

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Preclincial Testing of Sorafenib and RAD001 in the Nf (fl/fl);DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging Dahkki Wu, Jianqiang, Dombi, Eva, Jousma, Edwin, Dunn, R. Scott, Lindquist, Diana, Schnell, Beverly M., Kim, Mi-Ok, Kim, AeRang, Widemann, Brigitte C., Cripe, Timothy P., Ratner, Nancy

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EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors Dahkki Wu, Jianqiang, Patmore, Deanna M., Jousma, Edwin, Eaves, David W., Breving, Kimberly, Patel, Ami V., Schwartz, Eric B., Fuchs, James R., Cripe, Timothy P., Stemmer-Rachamimov, Anat O., Ratner, Nancy

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Neurofibroma-associated macrophages play roles in tumor growth and response to pharmacological inhibition Dahkki Prada, Carlos E., Jousma, Edwin, Rizvi, Tilat A., Wu, Jianqiang, Dunn, R. Scott, Mayes, Debra A., Cancelas, Jose A., Dombi, Eva, Kim, Mi-Ok, West, Brian L., Bollag, Gideon, Ratner, Nancy

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PM-18 EGFR-STAT3 ACTIVATES β-CATENIN SIGNALING TO DRIVE NEUROFIBROMA INITIATION IN NF1, AND PLAYS A ROLE IN TUMOR MAINTENANCE Dahkki Ratner, Nancy, Keng, Vincent, Patmore, Deanna M., Kendall, Jed K., Jousma, Edwin, Choi, Kwangmin, Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Cancelas, Jose A., Stemmer-Rachamimov, Anat, Spinner, Robert J., Largaespada, David A.

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MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors Dahkki Jessen, Walter J., Miller, Shyra J., Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A., Brundage, Meghan E., Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P., Giovannini, Marco, Aronow, Bruce J., Cripe, Timothy P., Ratner, Nancy

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Insertional mutagenesis identifies a STAT3/Arid1b/β-catenin pathway driving neurofibroma initiation Dahkki Wu, Jianqiang, Keng, Vincent, Patmore, Deanna M., Kendall, Jed K., Patel, Ami V., Jousma, Edwin, Jessen, Walter J., Choi, Kwangmin, Tschida, Barbara R., Silverstein, Kevin A. T., Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Huang, Gang, Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Spinner, Robert J., Largaespada, David A., Ratner, Nancy

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