Resultats de la cerca - Joseph M. Replogle

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  1. 1
    Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection

    Common Risk Alleles for Inflammatory Diseases Are Targets of Recent Positive Selection per Towfique Raj, Manik Kuchroo, Joseph M. Replogle, Soumya Raychaudhuri, Barbara E. Stranger, Philip L. De Jager

    Publicat 2013
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  2. 2
    Exploring genetic interaction manifolds constructed from rich single-cell phenotypes

    Exploring genetic interaction manifolds constructed from rich single-cell phenotypes per Thomas M. Norman, Max A. Horlbeck, Joseph M. Replogle, Alex Y. Ge, Albert Xu, Marco Jost, Luke A. Gilbert, Jonathan S. Weissman

    Publicat 2019
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  3. 3
    Nucleosomes impede Cas9 access to DNA in vivo and in vitro

    Nucleosomes impede Cas9 access to DNA in vivo and in vitro per Max A. Horlbeck, Lea B. Witkowsky, Benjamin Guglielmi, Joseph M. Replogle, Luke A. Gilbert, Jacqueline E. Villalta, Sharon E. Torigoe, Robert Tjian, Jonathan S. Weissman

    Publicat 2016
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  4. 4
    Mapping Transcriptomic Vector Fields of Single Cells

    Mapping Transcriptomic Vector Fields of Single Cells per Xiaojie Qiu, Yan Zhang, Shayan Hosseinzadeh, Dian Yang, Angela N. Pogson, Li Wang, Matt Shurtleff, Ruoshi Yuan, Xu Song, Yi-An Ma, Joseph M. Replogle, Spyros Darmanis, İvet Bahar, Jianhua Xing, Jonathan S. Weissman

    Publicat 2019
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  5. 5
    GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control

    GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control per Kelsey Hickey, Kimberley Dickson, J. Zachery Cogan, Joseph M. Replogle, Michael Schoof, Karole N. D’Orazio, Niladri K. Sinha, Jeffrey A. Hussmann, Marco Jost, Adam Frost, Rachel Green, Jonathan S. Weissman, Kamena K. Kostova

    Publicat 2020
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  6. 6
    Interindividual variation in human T regulatory cells

    Interindividual variation in human T regulatory cells per Alessandra M. Ferraro, Anna Morena D’Alise, Towfique Raj, Natasha Asinovski, Roxanne Phillips, Ayla Ergün, Joseph M. Replogle, Angelina Bernier, Lori M. Laffel, Barbara E. Stranger, Philip L. De Jager, Diane Mathis, Christophe Benoist

    Publicat 2014
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  7. 7
    A <scp><i>TREM</i></scp><i>1</i> variant alters the accumulation of Alzheimer‐related amyloid pathology

    A <scp><i>TREM</i></scp><i>1</i> variant alters the accumulation of Alzheimer‐related amyloid pathology per Joseph M. Replogle, Gail Chan, Charles C. White, Towfique Raj, Phoebe A. Winn, Denis A. Evans, Reisa A. Sperling, Lori B. Chibnik, Elizabeth M. Bradshaw, Julie A. Schneider, David A. Bennett, Philip L. De Jager

    Publicat 2014
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  8. 8
    CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility

    CD33: increased inclusion of exon 2 implicates the Ig V-set domain in Alzheimer's disease susceptibility per Towfique Raj, Kenneth J. Ryan, Joseph M. Replogle, Lori B. Chibnik, Laura Rosenkrantz, Acacia Tsz So Tang, Katherine Rothamel, Barbara E. Stranger, David A. Bennett, Denis A. Evans, Philip L. De Jager, Elizabeth M. Bradshaw

    Publicat 2013
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  9. 9
    MTCH2 is a mitochondrial outer membrane protein insertase

    MTCH2 is a mitochondrial outer membrane protein insertase per Alina Guna, Taylor A. Stevens, Alison J. Inglis, Joseph M. Replogle, Theodore K. Esantsi, Gayathri Muthukumar, Kelly Shaffer, Maxine L. Wang, Angela N. Pogson, Jeff Jones, Brett Lomenick, Tsui‐Fen Chou, Jonathan S. Weissman, R.M. Voorhees

    Publicat 2022
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  10. 10
    Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

    Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning per Luke W. Koblan, Mandana Arbab, Max W. Shen, Jeffrey A. Hussmann, Andrew V. Anzalone, Jordan L. Doman, Gregory A. Newby, Dian Yang, Beverly Mok, Joseph M. Replogle, Albert Xu, Tyler A. Sisley, Jonathan S. Weissman, Britt Adamson, David R. Liu

    Publicat 2021
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  11. 11
    CD33 modulates TREM2: convergence of Alzheimer loci

    CD33 modulates TREM2: convergence of Alzheimer loci per Gail Chan, Charles C. White, Phoebe A. Winn, Maria Cimpean, Joseph M. Replogle, Laura Glick, Nicole Cuerdon, Katie J. Ryan, Keith A. Johnson, Julie A. Schneider, David A. Bennett, Lori B. Chibnik, Reisa A. Sperling, Elizabeth M. Bradshaw, Philip L. De Jager

    Publicat 2015
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  12. 12
    Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing

    Combinatorial single-cell CRISPR screens by direct guide RNA capture and targeted sequencing per Joseph M. Replogle, Thomas M. Norman, Albert Xu, Jeffrey A. Hussmann, Jin Chen, J. Zachery Cogan, Elliott J. Meer, Jessica M. Terry, Daniel P. Riordan, Niranjan Srinivas, Ian T. Fiddes, Joseph G. Arthur, Luigi J. Alvarado, Katherine A. Pfeiffer, Tarjei S. Mikkelsen, Jonathan S. Weissman, Britt Adamson

    Publicat 2020
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  13. 13
    Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

    Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq per Joseph M. Replogle, Reuben A. Saunders, Angela N. Pogson, Jeffrey A. Hussmann, Alexander LeNail, Alina Guna, Lauren G. Mascibroda, Eric J. Wagner, Karen Adelman, Gila Lithwick‐Yanai, Nika Iremadze, Florian C. Oberstrass, Doron Lipson, Jessica L. Bonnar, Marco Jost, Thomas M. Norman, Jonathan S. Weissman

    Publicat 2022
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  14. 14
    Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus

    Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus per James Bentham, David Morris, Deborah S. Cunninghame Graham, Christopher L. Pinder, Philip Tombleson, Timothy W. Behrens, Javier Martı́n, Benjamin P. Fairfax, Julian C. Knight, Lingyan Chen, Joseph M. Replogle, Ann-Christine Syvänen, Lars Rönnblom, Robert Graham, Joan Wither, John D. Rioux, Marta E. Alarcón‐Riquelme, Timothy J. Vyse

    Publicat 2015
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  15. 15
    Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq

    Systematic functional interrogation of SARS-CoV-2 host factors using Perturb-seq per Sara Sunshine, Andreas S. Puschnik, Joseph M. Replogle, Matthew T. Laurie, Jamin Liu, Beth Shoshana Zha, James K. Nuñez, Janie R. Byrum, Aidan H. McMorrow, Matthew B. Frieman, Juliane Winkler, Xiaojie Qiu, Oren S. Rosenberg, Manuel D. Leonetti, Chun Ye, Jonathan S. Weissman, Joseph L. DeRisi, Marco Y. Hein

    Publicat 2023
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  16. 16
    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

    Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors per Joseph M. Replogle, Jessica L. Bonnar, Angela N. Pogson, Christina R. Liem, Nolan K Maier, Yufang Ding, Baylee J. Russell, Wang Xing-ren, Kun Leng, Alina Guna, Thomas M. Norman, Ryan A. Pak, Daniel M. Ramos, Michael E. Ward, Luke A. Gilbert, Martin Kampmann, Jonathan S. Weissman, Marco Jost

    Publicat 2022
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  17. 17
    A pharmacogenetic study implicates <scp><i>SLC9a9</i></scp> in multiple sclerosis disease activity

    A pharmacogenetic study implicates <scp><i>SLC9a9</i></scp> in multiple sclerosis disease activity per Federica Esposito, Melissa Sorosina, Linda Ottoboni, Elaine T. Lim, Joseph M. Replogle, Towfique Raj, Paola Brambilla, Giuseppe Liberatore, Clara Guaschino, Marzia Romeo, Thomas Pertel, James Stankiewicz, Vittorio Martinelli, Mariaemma Rodegher, Howard L. Weiner, David Brassat, Christophe Benoist, Nikolaos A. Patsopoulos, Gıancarlo Comı, Wassim Elyaman, Filippo Martinelli Boneschi, Philip L. De Jager

    Publicat 2015
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  18. 18
    A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants

    A human microglia-like cellular model for assessing the effects of neurodegenerative disease gene variants per Katie J. Ryan, Charles C. White, K R Patel, Jishu Xu, Marta Olah, Joseph M. Replogle, Michael Frangieh, Maria Cimpean, Phoebe A. Winn, Allison McHenry, Belinda J. Kaskow, Gail Chan, Nicole Cuerdon, David A. Bennett, Justin D. Boyd, Jaime Imitola, Wassim Elyaman, Philip L. De Jager, Elizabeth M. Bradshaw

    Publicat 2017
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  19. 19
    Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing

    Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing per James K. Nuñez, Jin Chen, Greg C. Pommier, J. Zachery Cogan, Joseph M. Replogle, Carmen Adriaens, Gokul N. Ramadoss, Quanming Shi, King L. Hung, Avi J. Samelson, Angela N. Pogson, James Y.S. Kim, Amanda G. Chung, Manuel D. Leonetti, Howard Y. Chang, Martin Kampmann, B Bernstein, Volker Hovestadt, Luke A. Gilbert, Jonathan S. Weissman

    Publicat 2021
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  20. 20
    Mapping transcriptomic vector fields of single cells

    Mapping transcriptomic vector fields of single cells per Xiaojie Qiu, Yan Zhang, Jorge D. Martin-Rufino, Chen Weng, Shayan Hosseinzadeh, Dian Yang, Angela N. Pogson, Marco Y. Hein, Kyung Hoi Min, Li Wang, Emanuelle I. Grody, Matthew J. Shurtleff, Ruoshi Yuan, Song Xu, Yi-An Ma, Joseph M. Replogle, Eric S. Lander, Spyros Darmanis, İvet Bahar, Vijay G. Sankaran, Jianhua Xing, Jonathan S. Weissman

    Publicat 2022
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