検索結果 - Jordan, Allan

Artificial Intelligence in Drug Design—The Storm Before the Calm? 著者: Jordan, Allan M.

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Molecularly profiled trials: toward a framework of actions for the “nil actionables” 著者: Jordan, Allan Michael

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Communicating Our Science to Our Customers: The Vital Role of Passionate Public Advocacy 著者: Jordan, Allan M., Grant, Richard P.

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Glucose 6-Phosphate Dehydrogenase from Trypanosomes: Selectivity for Steroids and Chemical Validation in Bloodstream Trypanosoma brucei 著者: Ortíz, Cecilia, Moraca, Francesca, Laverriere, Marc, Jordan, Allan, Hamilton, Niall, Comini, Marcelo A.

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ERK5 is a critical mediator of inflammation-driven cancer 著者: Finegan, Katherine G., Perez-Madrigal, Diana, Hitchin, James R., Davies, Clare, Jordan, Allan M., Tournier, Cathy

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Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells 著者: Atkin, Jane, Halova, Lenka, Ferguson, Jennifer, Hitchin, James R., Lichawska-Cieslar, Agata, Jordan, Allan M., Pines, Jonathon, Wellbrock, Claudia, Petersen, Janni

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Discovery of a Gatekeeper Residue in the C-Terminal Tail of the Extracellular Signal-Regulated Protein Kinase 5 (ERK5) 著者: Pearson, Adam J., Fullwood, Paul, Toro Tapia, Gabriela, Prise, Ian, Smith, Michael P., Xu, Qiuping, Jordan, Allan, Giurisato, Emanuele, Whitmarsh, Alan J., Francavilla, Chiara, Tournier, Cathy

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Pluripotent hematopoietic stem cells augment α-adrenergic receptor-mediated contraction of pulmonary artery and contribute to the pathogenesis of pulmonary hypertension 著者: Hashimoto, Ryota, Lanier, Gregg M., Dhagia, Vidhi, Joshi, Sachindra R., Jordan, Allan, Waddell, Ian, Tuder, Rubin, Stenmark, Kurt R., Wolin, Michael S., McMurtry, Ivan F., Gupte, Sachin A.

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Identification of selective inhibitors of RET and comparison with current clinical candidates through development and validation of a robust screening cascade 著者: Watson, Amanda J., Hopkins, Gemma V., Hitchin, Samantha, Begum, Habiba, Jones, Stuart, Jordan, Allan, Holt, Sarah, March, H. Nikki, Newton, Rebecca, Small, Helen, Stowell, Alex, Waddell, Ian D., Waszkowycz, Bohdan, Ogilvie, Donald J.

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Discovery and Optimization of wt-RET/KDR-Selective Inhibitors of RET(V804M) Kinase 著者: Newton, Rebecca, Waszkowycz, Bohdan, Seewooruthun, Chitra, Burschowsky, Daniel, Richards, Mark, Hitchin, Samantha, Begum, Habiba, Watson, Amanda, French, Eleanor, Hamilton, Niall, Jones, Stuart, Lin, Li-Ying, Waddell, Ian, Echalier, Aude, Bayliss, Richard, Jordan, Allan M., Ogilvie, Donald

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Fluoromethylcyclopropylamine derivatives as potential in vivo toxicophores – A cautionary disclosure 著者: Acton, Ben, Small, Helen F., Smith, Kate M., McGonagle, Alison, Stowell, Alexandra I.J., James, Dominic I., Hamilton, Niall M., Hamilton, Nicola, Hitchin, James R., Hutton, Colin P., Waddell, Ian D., Ogilvie, Donald J., Jordan, Allan M.

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Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methyl... 著者: Joshi, Sachindra Raj, Kitagawa, Atsushi, Jacob, Christina, Hashimoto, Ryota, Dhagia, Vidhi, Ramesh, Amrit, Zheng, Connie, Zhang, Hui, Jordan, Allan, Waddell, Ian, Leopold, Jane, Hu, Cheng-Jun, McMurtry, Ivan F., D’Alessandro, Angelo, Stenmark, Kurt R., Gupte, Sachin A.

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Anilinoquinazoline inhibitors of the RET kinase domain—Elaboration of the 7-position 著者: Jordan, Allan M., Begum, Habiba, Fairweather, Emma, Fritzl, Samantha, Goldberg, Kristin, Hopkins, Gemma V., Hamilton, Niall M., Lyons, Amanda J., March, H. Nikki, Newton, Rebecca, Small, Helen F., Vishwanath, Swamy, Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors 著者: Pillay, Nisha, Tighe, Anthony, Nelson, Louisa, Littler, Samantha, Coulson-Gilmer, Camilla, Bah, Nourdine, Golder, Anya, Bakker, Bjorn, Spierings, Diana C.J., James, Dominic I., Smith, Kate M., Jordan, Allan M., Morgan, Robert D., Ogilvie, Donald J., Foijer, Floris, Jackson, Dean A., Taylor, Stephen S.

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Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2 著者: Hornyak, Peter, Askwith, Trevor, Walker, Sarah, Komulainen, Emilia, Paradowski, Michael, Pennicott, Lewis E., Bartlett, Edward J., Brissett, Nigel C., Raoof, Ali, Watson, Mandy, Jordan, Allan M., Ogilvie, Donald J., Ward, Simon E., Atack, John R., Pearl, Laurence H., Caldecott, Keith W., Oliver, Antony W.

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Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia 著者: Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.

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Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1 著者: Murray, James B., Davidson, James, Chen, Ijen, Davis, Ben, Dokurno, Pawel, Graham, Christopher J., Harris, Richard, Jordan, Allan, Matassova, Natalia, Pedder, Christopher, Ray, Stuart, Roughley, Stephen D., Smith, Julia, Walmsley, Claire, Wang, Yikang, Whitehead, Neil, Williamson, Douglas S., Casara, Patrick, Le Diguarher, Thierry, Hickman, John, Stark, Jerome, Kotschy, András, Geneste, Olivier, Hubbard, Roderick E.

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In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor 著者: Gilmartin, Aidan G., Groy, Arthur, Gore, Elizabeth R., Atkins, Charity, Long, Edward R., Montoute, Monica N., Wu, Zining, Halsey, Wendy, McNulty, Dean E., Ennulat, Daniela, Rueda, Lourdes, Pappalardi, Melissa B., Kruger, Ryan G., McCabe, Michael T., Raoof, Ali, Butlin, Roger, Stowell, Alexandra, Cockerill, Mark, Waddell, Ian, Ogilvie, Donald, Luengo, Juan, Jordan, Allan, Benowitz, Andrew B.

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Poly (ADP) ribose glycohydrolase can be effectively targeted in pancreatic cancer 著者: Jain, Aditi, Agostini, Lebaron C., McCarthy, Grace A., Chand, Saswati N., Ramirez, AnnJosette, Nevler, Avinoam, Cozzitorto, Joseph, Schultz, Christopher W., Lowder, Cinthya Yabar, Smith, Kate M., Waddell, Ian D., Raitses-Gurevich, Maria, Stossel, Chani, Gorman, Yulia Glick, Atias, Dikla, Yeo, Charles J., Winter, Jordan M., Olive, Kenneth P., Golan, Talia, Pishvaian, Michael J., Ogilvie, Donald, James, Dominic I., Jordan, Allan M., Brody, Jonathan R.

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The discovery of 2-substituted phenol quinazolines as potent RET kinase inhibitors with improved KDR selectivity 著者: Newton, Rebecca, Bowler, Katherine A., Burns, Emily M., Chapman, Philip J., Fairweather, Emma E., Fritzl, Samantha J.R., Goldberg, Kristin M., Hamilton, Niall M., Holt, Sarah V., Hopkins, Gemma V., Jones, Stuart D., Jordan, Allan M., Lyons, Amanda J., Nikki March, H., McDonald, Neil Q., Maguire, Laura A., Mould, Daniel P., Purkiss, Andrew G., Small, Helen F., Stowell, Alexandra I.J., Thomson, Graeme J., Waddell, Ian D., Waszkowycz, Bohdan, Watson, Amanda J., Ogilvie, Donald J.

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