Canlyniadau Chwilio - Jonchere, Barbara

STAT3 as a new autophagy regulator gan Jonchère, Barbara, Bélanger, Audrey, Guette, Catherine, Barré, Benjamin, Coqueret, Olivier

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PDTM-02. TARGETING THE RB PATHWAY IN MEDULLOBLASTOMA gan Jonchere, Barbara, Stripay, Jennifer, Pribnow, Allison, Zindy, Frederique, Min, Jaeki, Freeman, Burgess, Shelat, Anang, Rankovic, Zoran, Roussel, Martine

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Akt inhibition improves irinotecan treatment and prevents cell emergence by switching the senescence response to apoptosis gan Vétillard, Alexandra, Jonchère, Barbara, Moreau, Marie, Toutain, Bertrand, Henry, Cécile, Fontanel, Simon, Bernard, Anne-Charlotte, Campone, Mario, Guette, Catherine, Coqueret, Olivier

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Regulation of senescence escape by the cdk4–EZH2–AP2M1 pathway in response to chemotherapy gan Le Duff, Mélanie, Gouju, Julien, Jonchère, Barbara, Guillon, Jordan, Toutain, Bertrand, Boissard, Alice, Henry, Cécile, Guette, Catherine, Lelièvre, Eric, Coqueret, Olivier

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INSP-09. Using genetically engineered mouse models and patient-derived orthotopic xenografts to develop new therapies for pediatric brain tumors. gan Jonchere, Barbara, Pribnow, Allison, Morfouace, Marie, Shelat, Anang, Yu, Jiyang, Rankovic, Zoran, Gajjar, Amar, Northcott, Paul A, Robinson, Giles W, Roussel, Martine F

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Distinct Merkel Cell Polyomavirus Molecular Features in Tumour and Non Tumour Specimens from Patients with Merkel Cell Carcinoma gan Laude, Hélène C., Jonchère, Barbara, Maubec, Eve, Carlotti, Agnès, Marinho, Eduardo, Couturaud, Benoit, Peter, Martine, Sastre-Garau, Xavier, Avril, Marie-Françoise, Dupin, Nicolas, Rozenberg, Flore

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Irinotecan treatment and senescence failure promote the emergence of more transformed and invasive cells that depend on anti-apoptotic Mcl-1 gan Jonchère, Barbara, Vétillard, Alexandra, Toutain, Bertrand, Lam, David, Bernard, Anne Charlotte, Henry, Cécile, Trécesson, Sophie De Carné, Gamelin, Erick, Juin, Philippe, Guette, Catherine, Coqueret, Olivier

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MEDB-42. GermlineElp1 deficiency promotes genomic instability and survival of granule neuron progenitors primed for SHH medulloblastoma pathogenesis gan Garcia-Lopez *, Jesus, Ahmad *, Shiekh Tanveer, Li *, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Roussel, Martine, Wainwright, Brandon, Kutscher, Lena, Lin #, Hong, Northcott #, Paul

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Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators gan Nishiguchi, Gisele, Keramatnia, Fatemeh, Min, Jaeki, Chang, Yunchao, Jonchere, Barbara, Das, Sourav, Actis, Marisa, Price, Jeanine, Chepyala, Divyabharathi, Young, Brandon, McGowan, Kevin, Slavish, P. Jake, Mayasundari, Anand, Jarusiewicz, Jamie A., Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Papizan, James B., Kodali, Kiran, Peng, Junmin, Pruett Miller, Shondra M., Roussel, Martine F., Mullighan, Charles, Fischer, Marcus, Rankovic, Zoran

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Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs gan Min, Jaeki, Mayasundari, Anand, Keramatnia, Fatemeh, Jonchere, Barbara, Yang, Seung Wook, Jarusiewicz, Jamie, Actis, Marisa, Das, Sourav, Young, Brandon, Slavish, Jake, Yang, Lei, Li, Yong, Fu, Xiang, Garrett, Shalandus H., Yun, Mi-Kyung, Li, Zhenmei, Nithianantham, Stanley, Chai, Sergio, Chen, Taosheng, Shelat, Anang, Lee, Richard E., Nishiguchi, Gisele, White, Stephen W., Roussel, Martine F., Potts, Patrick Ryan, Fischer, Marcus, Rankovic, Zoran

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Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer gan Slavish, P. Jake, Chi, Liying, Yun, Mi-Kyung, Tsurkan, Lyudmila, Martinez, Nancy E., Jonchere, Barbara, Chai, Sergio C., Connelly, Michele, Waddell, M. Brett, Das, Sourav, Neale, Geoffrey, Li, Zhenmei, Shadrick, William R., Olsen, Rachelle R., Freeman, Kevin W., Low, Jonathan A., Price, Jeanine E., Young, Brandon M., Bharatham, Nagakumar, Boyd, Vincent A., Yang, Jun, Lee, Richard E., Morfouace, Marie, Roussel, Martine F., Chen, Taosheng, Savic, Daniel, Guy, R. Kiplin, White, Stephen W., Shelat, Anang A., Potter, Philip M.

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Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma gan He, Chen, Xu, Ke, Zhu, Xiaoyan, Dunphy, Paige S., Gudenas, Brian, Lin, Wenwei, Twarog, Nathaniel, Hover, Laura D., Kwon, Chang-Hyuk, Kasper, Lawryn H., Zhang, Junyuan, Li, Xiaoyu, Dalton, James, Jonchere, Barbara, Mercer, Kimberly S., Currier, Duane G., Caufield, William, Wang, Yingzhe, Xie, Jia, Broniscer, Alberto, Wetmore, Cynthia, Upadhyaya, Santhosh A., Qaddoumi, Ibrahim, Klimo, Paul, Boop, Frederick, Gajjar, Amar, Zhang, Jinghui, Orr, Brent A., Robinson, Giles W., Monje, Michelle, Freeman III, Burgess B., Roussel, Martine F., Northcott, Paul A., Chen, Taosheng, Rankovic, Zoran, Wu, Gang, Chiang, Jason, Tinkle, Christopher L., Shelat, Anang A., Baker, Suzanne J.

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