Canlyniadau Chwilio - Jonathan Whittaker
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Design and Folding of [Glu<sup>A4</sup>(O<sup>β</sup>Thr<sup>B30</sup>)]Insulin (“Ester Insulin”): A Minimal Proinsulin Surrogate that Can Be Chemically Converted into Human Insuli... gan Youhei Sohma, Qing‐Xin Hua, Jonathan Whittaker, Michael A. Weiss, Stephen B. H. Kent
Cyhoeddwyd 2010Artigo -
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Overexpression of Insulin Receptors in Fibroblast and Ovary Cells Induces a Ligand-Mediated Transformed Phenotype gan Francesco Giorgino, Antonino Belfiore, Giovanni Milazzo, Angela Costantino, Betty A. Maddux, Jonathan Whittaker, Ira D. Goldfine, Riccardo Vigneri
Cyhoeddwyd 1991Artigo -
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Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain gan Tristan I. Croll, Brian J. Smith, Mai B. Margetts, Jonathan Whittaker, Michael A. Weiss, Colin W. Ward, Michael C. Lawrence
Cyhoeddwyd 2016Artigo -
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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists gan Brian J. Smith, Kun Huang, G.K.-W. Kong, Shu Jin Chan, Satoe H. Nakagawa, John G. Menting, Shi-Quan Hu, Jonathan Whittaker, Donald F. Steiner, Panayotis G. Katsoyannis, Colin W. Ward, Michael A. Weiss, Michael C. Lawrence
Cyhoeddwyd 2010Artigo -
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An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein gan Michael D. Glidden, Khadijah Aldabbagh, Nelson B. Phillips, Kelley Carr, Yen-Shan Chen, Jonathan Whittaker, Manijeh Phillips, Nalinda P. Wickramasinghe, Nischay Rege, Mamuni Swain, Yi Peng, Yanwu Yang, Michael C. Lawrence, Vivien C. Yee, Faramarz Ismail‐Beigi, Michael A. Weiss
Cyhoeddwyd 2017Artigo -
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How insulin engages its primary binding site on the insulin receptor gan John G. Menting, Jonathan Whittaker, Mai B. Margetts, Linda Whittaker, G.K.-W. Kong, Brian J. Smith, Christopher J.E. Watson, Lenka Žáková, Emília Kletvíková, Jiřı́ Jiráček, Shu Jin Chan, Donald F. Steiner, Guy Dodson, A.M. Brzozowski, Michael A. Weiss, Colin W. Ward, Michael C. Lawrence
Cyhoeddwyd 2013Artigo -
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Protective hinge in insulin opens to enable its receptor engagement gan John G. Menting, Yanwu Yang, Shu Jin Chan, Nelson B. Phillips, Brian J. Smith, Jonathan Whittaker, Nalinda P. Wickramasinghe, Linda Whittaker, Vijay Pandyarajan, Zhu‐li Wan, Satya P. Yadav, Julie M. Carroll, Natalie Strokes, Charles T. Roberts, Faramarz Ismail‐Beigi, Wieslawa Milewski, Donald F. Steiner, Virander S. Chauhan, Colin W. Ward, Michael A. Weiss, Michael C. Lawrence
Cyhoeddwyd 2014Artigo
Offerynnau Chwilio:
Pynciau Perthynol
Biology
Insulin
Biochemistry
Endocrinology
Insulin receptor
Insulin resistance
Receptor
Chemistry
Gene
Binding site
Mutagenesis
Cell biology
Ligand (biochemistry)
Molecular biology
Alanine
Alanine scanning
Amino acid
Biophysics
Computational biology
Genetics
Human insulin
Insulin receptor substrate
Internal medicine
Materials science
Medicine
Mutant
Ectodomain
GRB10
Mutation
Protein subunit