Search Results - John G. Doench

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  1. 1
    Specificity of microRNA target selection in translational repression

    Specificity of microRNA target selection in translational repression by John G. Doench, Phillip A. Sharp

    Published 2004
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  2. 2
    Comparison of siRNA-induced off-target RNA and protein effects

    Comparison of siRNA-induced off-target RNA and protein effects by Lourdes M. Alemán, John G. Doench, Phillip A. Sharp

    Published 2007
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  3. 3
    siRNAs can function as miRNAs

    siRNAs can function as miRNAs by John G. Doench, Christian P. Petersen, Phillip A. Sharp

    Published 2003
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  4. 4
    Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens

    Uncoupling of sgRNAs from their associated barcodes during PCR amplification of combinatorial CRISPR screens by Mudra Hegde, Christine Strand, Ruth E. Hanna, John G. Doench

    Published 2018
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  5. 5
    <i>In Silico</i>Predictive Modeling of CRISPR/Cas9 guide efficiency

    <i>In Silico</i>Predictive Modeling of CRISPR/Cas9 guide efficiency by Nicolò Fusi, Ian C. P. Smith, John G. Doench, Jennifer Listgarten

    Published 2015
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  6. 6
    Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro

    Recapitulation of Short RNA-Directed Translational Gene Silencing In Vitro by Bingbing Wang, Tara M. Love, Matthew E. Call, John G. Doench, Carl D. Novina

    Published 2006
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  7. 7
    Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons

    Natural variation in a single amino acid substitution underlies physiological responses to topoisomerase II poisons by Stefan Zdraljevic, Christine Strand, Hannah S. Seidel, Daniel E. Cook, John G. Doench, Erik C. Andersen

    Published 2017
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  8. 8
    Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression

    Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB–dependent IFITM3 expression by Moiz Munir, Aaron Embry, John G. Doench, Nicholas S. Heaton, Craig B. Wilen, Robert C. Orchard

    Published 2024
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  9. 9
    Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation

    Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation by Asaf Rotem, Andreas Janzer, Benjamin Izar, Zhe Ji, John G. Doench, Levi A. Garraway, Kevin Struhl

    Published 2015
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  10. 10
    Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening

    Accounting for small variations in the tracrRNA sequence improves sgRNA activity predictions for CRISPR screening by Peter C. DeWeirdt, Abby V. McGee, Fengyi Zheng, Ifunanya Nwolah, Mudra Hegde, John G. Doench

    Published 2022
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  11. 11
    Base editor scanning charts the DNMT3A activity landscape

    Base editor scanning charts the DNMT3A activity landscape by Nicholas Z. Lue, Emma M. Garcia, Kevin C. Ngan, Ceejay Lee, John G. Doench, Brian B. Liau

    Published 2022
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  12. 12
    Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening

    Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening by Robert C. Orchard, Meagan E. Sullender, Bria F. Dunlap, Dale R. Balce, John G. Doench, Herbert W. Virgin

    Published 2018
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  13. 13
    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool

    Creation of Novel Protein Variants with CRISPR/Cas9-Mediated Mutagenesis: Turning a Screening By-Product into a Discovery Tool by Katherine Donovan, Mudra Hegde, Meagan E. Sullender, Emma W Vaimberg, Cory M. Johannessen, David E. Root, John G. Doench

    Published 2017
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  14. 14
    Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death

    Defective NADPH production in mitochondrial disease complex I causes inflammation and cell death by Eduardo Balsa, Elizabeth A. Perry, Christopher F. Bennett, Mark P. Jedrychowski, Steven P. Gygi, John G. Doench, Pere Puigserver

    Published 2020
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  15. 15
    Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

    Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin by Tobias Wijshake, Zhongju Zou, Beibei Chen, Lin Zhong, Guanghua Xiao, Yang Xie, John G. Doench, Lynda Bennett, Beth Levine

    Published 2021
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  16. 16
    A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation

    A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation by Jason D. Arroyo, Alexis A. Jourdain, Sarah E. Calvo, Carmine Ballarano, John G. Doench, David E. Root, Vamsi K. Mootha

    Published 2016
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  17. 17
    Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells

    Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cells by Sumit K. Matta, Hinissan P. Kohio, Pallavi Chandra, Adam Brown, John G. Doench, Jennifer A. Philips, Siyuan Ding, L. David Sibley

    Published 2023
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  18. 18
    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects

    Morphological Profiles of RNAi-Induced Gene Knockdown Are Highly Reproducible but Dominated by Seed Effects by Shantanu Singh, Xiaoyun Wu, Vebjorn Ljosa, Mark‐Anthony Bray, Federica Piccioni, David E. Root, John G. Doench, Jesse S. Boehm, Anne E. Carpenter

    Published 2015
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  19. 19
    Genetic screens in isogenic mammalian cell lines without single cell cloning

    Genetic screens in isogenic mammalian cell lines without single cell cloning by Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench

    Published 2020
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  20. 20
    Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform

    Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform by Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori Wilson, Ryan Steger, Annabel K. Sangree, Medina Colic, Sidney H. Wang, John G. Doench, Traver Hart

    Published 2024
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