Ngā hua rapu kaituhi :: APM

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Why do BCL-2 inhibitors work and where should we use them in the clinic? mā Joan Montero, Antony Letai

I whakaputaina 2017

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Revisão

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2

Adapted to Survive: Targeting Cancer Cells with BH3 Mimetics mā Joan Montero, Rizwan Haq

I whakaputaina 2022

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Revisão

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3

p53 regulates a non-apoptotic death induced by ROS mā Joan Montero, Chaitali Dutta, Diederik van Bodegom, David M. Weinstock, Anthony Letai

I whakaputaina 2013

Whiwhi kuputuhi katoa
Artigo

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4

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death mā Joan Montero, Montserrat Marı́, Anna Colell, Albert Morales, Gorka Basáñez, Carmen García‐Ruiz, José C. Fernández–Checa

I whakaputaina 2010

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Revisão

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5

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response mā Kristopher A. Sarosiek, Xiaoke Chi, John A. Bachman, Joshua J. Sims, Joan Montero, Luv Patel, Annabelle Flanagan, David W. Andrews, Peter K. Sorger, Anthony Letai

I whakaputaina 2013

Whiwhi kuputuhi katoa
Artigo

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6

Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response mā Donglim Esther Park, Jingwei Cheng, Christian Berrios, Joan Montero, Marta Cortés-Cros, Stéphane Ferretti, Reety Arora, Michelle Tillgren, Prafulla C. Gokhale, James A. DeCaprio

I whakaputaina 2018

Whiwhi kuputuhi katoa Whiwhi kuputuhi katoa
Artigo

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7

Mitochondrial Cholesterol Contributes to Chemotherapy Resistance in Hepatocellular Carcinoma mā Joan Montero, Albert Morales, Laura Llacuna, Josep M. Lluis, Oihana Terrones, Gorka Basáñez, Bruno Antonsson, Jesús Prìeto, Carmen García‐Ruiz, Anna Colell, José C. Fernández–Checa

I whakaputaina 2008

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Artigo

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8

<scp>KPT</scp>‐330 inhibitor of <scp>CRM</scp>1 (<scp>XPO</scp>1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of <scp>T</scp>‐cell acute lym... mā Julia Etchin, Takaomi Sanda, Marc R. Mansour, Alex Kentsis, Joan Montero, Bonnie Le, Amanda L. Christie, Dilara McCauley, Scott J. Rodig, Michael Kauffman, Sharon Shacham, Richard M. Stone, Anthony Letai, Andrew L. Kung, A. Thomas Look

I whakaputaina 2013

Whiwhi kuputuhi katoa
Artigo

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9

Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies mā Joan Montero, Cécile Gstalder, Daniel J. Kim, Dorota Sadowicz, Wayne Miles, Michael P. Manos, Justin Cidado, J. Paul Secrist, Adriana E. Tron, Keith T. Flaherty, F. Stephen Hodi, Charles H. Yoon, Anthony Letai, David E. Fisher, Rizwan Haq

I whakaputaina 2019

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Artigo

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10

Targeted apoptosis of myofibroblasts with the BH3 mimetic ABT-263 reverses established fibrosis mā David Lagares, Alba Santos, Paula Grasberger, Fei Liu, Clemens K. Probst, Rod A. Rahimi, Norihiko Sakai, Tobias Kuehl, Jeremy Ryan, Patrick Bhola, Joan Montero, Mohit Kapoor, Murray Baron, Xaralabos Varelas, Daniel J. Tschumperlin, Anthony Letai, Andrew M. Tager

I whakaputaina 2017

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Artigo

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11

Blastic Plasmacytoid Dendritic Cell Neoplasm Is Dependent on BCL2 and Sensitive to Venetoclax mā Joan Montero, Jason Stephansky, Tianyu Cai, Gabriel K. Griffin, Lucía Cabal‐Hierro, Katsuhiro Togami, Leah J. Hogdal, Ilene Galinsky, Elizabeth A. Morgan, Jon C. Aster, Matthew S. Davids, Nicole R. LeBoeuf, Richard M. Stone, Marina Konopleva, Naveen Pemmaraju, Anthony Letai, Andrew A. Lane

I whakaputaina 2016

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Artigo

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12

DNA methyltransferase inhibition overcomes diphthamide pathway deficiencies underlying CD123-targeted treatment resistance mā Katsuhiro Togami, Timothy J. Pastika, Jason Stephansky, Mahmoud Ghandi, Amanda L. Christie, Kristen L. Jones, C. Anderson Johnson, Ross Lindsay, Christopher Brooks, Anthony Letai, Jeffrey W. Craig, Olga Pozdnyakova, David M. Weinstock, Joan Montero, Jon C. Aster, Cory M. Johannessen, Andrew A. Lane

I whakaputaina 2019

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Artigo

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13

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells mā Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. K. Venkatapoorna, Zeng Hu, Fernando Martín, Kevin M. Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menéndez, Ruth Lupu

I whakaputaina 2021

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Artigo

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14

The 2-oxoglutarate carrier promotes liver cancer by sustaining mitochondrial GSH despite cholesterol loading mā Anna Baulies, Joan Montero, Núria Matías, Naroa Insausti-Urkia, Oihana Terrones, Gorka Basáñez, Carmen G. Vallejo, Laura Conde de la Rosa, Laura Martinez‐Gili, David Robles, Albert Morales, Joaquín Abián, Montserrat Carrascal, Keigo Machida, Dinesh Babu Uthaya Kumar, Hidekazu Tsukamoto, Neil Kaplowitz, Carmen Garcı́a-Ruiz, José C. Fernández–Checa

I whakaputaina 2017

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Artigo

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15

Reactivation of ERK Signaling Causes Resistance to EGFR Kinase Inhibitors mā Dalia Ercan, Chunxiao Xu, Masahiko Yanagita, Calixte S. Monast, Christine A. Pratilas, Joan Montero, Mohit Butaney, Takeshi Shimamura, Lynette M. Sholl, Elena Ivanova, Madhavi Tadi, Andrew M. Rogers, Claire E. Repellin, Marzia Capelletti, Ophélia Maertens, Eva M. Goetz, Anthony Letai, Levi A. Garraway, Matthew J. Lazzara, Neal Rosen, Nathanael S. Gray, Kwok‐Kin Wong, Pasi A. Jänne

I whakaputaina 2012

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Artigo

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16

Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice mā Julia Etchin, Joan Montero, Alla Berezovskaya, Bonnie Le, Alex Kentsis, Amanda L. Christie, Amy Saur Conway, W C Chen, Casie Reed, Marc R. Mansour, Cherry Ee Lin Ng, Sophia Adamia, Scott J. Rodig, Ilene Galinsky, Richard M. Stone, Boris Klebanov, Yosef Landesman, Michael Kauffman, Sharon Shacham, Andrew L. Kung, Jean Wang, Anthony Letai, A. Thomas Look

I whakaputaina 2015

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Artigo

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17

BH3 mimetics targeting BCL-XL impact the senescent compartment of pilocytic astrocytoma mā Florian Selt, Romain Sigaud, Gintvile Valinciute, Philipp Sievers, Julia Zaman, Clara Alcon, Simone Schmid, Heike Peterziel, Jessica W. Tsai, Romain Guiho, Juan Pedro Martı́nez-Barberá, Stefan Pusch, Jing Deng, Yifan Zhai, Cornelis M. van Tilburg, Martin U Schuhman, Ahmed El Damaty, Pratiti Bandopadhayay, Christel Herold‐Mende, Andreas von Deimling, Stefan M. Pfister, Joan Montero, David Capper, Ina Oehme, Felix Sahm, David Jones, Olaf Witt, Till Milde

I whakaputaina 2022

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Artigo

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18

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer mā Elizabeth H. Stover, Maria B. Baco, Ofir Cohen, Yvonne Y. Li, Elizabeth L. Christie, Mukta Bagul, Amy Goodale, Yenarae Lee, Sasha Pantel, Matthew G. Rees, Guo Wei, Adam G. Presser, Maya K. Gelbard, Weiqun Zhang, Ioannis K. Zervantonakis, Patrick Bhola, Jeremy Ryan, Jennifer L. Guerriero, Joan Montero, Felice J. Liang, Andrew D. Cherniack, Federica Piccioni, Ursula A. Matulonis, David D.L. Bowtell, Kristopher A. Sarosiek, Anthony Letai, Levi A. Garraway, Cory M. Johannessen, Matthew Meyerson

I whakaputaina 2019

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Artigo

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19

CDK4/6 inhibition reprograms the breast cancer enhancer landscape by stimulating AP-1 transcriptional activity mā April C. Watt, Paloma Cejas, Molly J. DeCristo, Otto Metzger, Enid Y.N. Lam, Xintao Qiu, Haley BrinJones, Nikolas Kesten, Rhiannon Coulson, Alba Font‐Tello, Klothilda Lim, Raga Vadhi, Veerle W. Daniëls, Joan Montero, Len Taing, Clifford A. Meyer, Omer Gilan, Charles C. Bell, Keegan Korthauer, Claudia Giambartolomei, Bogdan Paşaniuc, Ji-Heui Seo, Matthew L. Freedman, X. Cynthia, Matthew J. Ellis, Ian E. Krop, Eric P. Winer, Anthony Letai, Myles Brown, Mark A. Dawson, Henry W. Long, Jean J. Zhao, Shom Goel

I whakaputaina 2020

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Artigo

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20

Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia mā Shuo-Chieh Wu, Loretta S. Li, Nadja Kopp, Joan Montero, Bjoern Chapuy, Akinori Yoda, Amanda L. Christie, Huiyun Liu, Alexandra Christodoulou, Diederik van Bodegom, Jordy Van Der Zwet, Jacob V. Layer, Trevor Tivey, Andrew A. Lane, Jeremy Ryan, Samuel Y. Ng, Daniel J. DeAngelo, Richard M. Stone, David P. Steensma, Martha Wadleigh, Marian H. Harris, Emeline Mandon, Nicolas Ebel, Rita Andraos, Vincent Romanet, Arno Dölemeyer, Dario Sterker, Michael Zender, Scott J. Rodig, Masato Murakami, Francesco Hofmann, Frank C. Kuo, Michael J. Eck, Lewis B. Silverman, Stephen E. Sallan, Anthony Letai, Fabienne Baffert, Eric Vangrevelinghe, Thomas Radimerski, Christoph Gaul, David M. Weinstock

I whakaputaina 2015

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Artigo

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