Výsledky vyhledávání - Janette Reader

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  1. 1
    Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites

    Epigenetic inhibitors target multiple stages of Plasmodium falciparum parasites Autor Nanika Coetzee, Hilde von Grüning, Daniel Opperman, Mariëtte van der Watt, Janette Reader, Lyn‐Marié Birkholtz

    Vydáno 2020
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  2. 2
    Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation

    Hierarchical transcriptional control regulates Plasmodium falciparum sexual differentiation Autor Riëtte van Biljon, Roelof van Wyk, Heather J. Painter, Lindsey Orchard, Janette Reader, Jandeli Niemand, Manuel Llinás, Lyn‐Marié Birkholtz

    Vydáno 2019
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  3. 3
    Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination

    Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination Autor Janette Reader, Mariëtte Botha, Anjo Theron, Sonja B. Lauterbach, Claire Rossouw, Dewaldt Engelbrecht, Melanie Wepener, Annél Smit, Didier Leroy, Dalu Mancama, Thérèsa L. Coetzer, Lyn‐Marié Birkholtz

    Vydáno 2015
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  4. 4
    Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages

    Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages Autor Dina Coertzen, Janette Reader, Mariëtte van der Watt, Sindisiwe H. Nondaba, Liezl Gibhard, Lubbe Wiesner, Peter G. Smith, Sarah D’Alessandro, Donatella Taramelli, Ho Ning Wong, Jan L. du Preez, Ronald Wai Keung Wu, Lyn‐Marié Birkholtz, Richard K. Haynes

    Vydáno 2018
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  5. 5
    Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and <i>In Vivo</i> Efficacy in a <i>Plasmodium berghei</i> Mouse Malaria Infection Model

    Novel 3-Trifluoromethyl-1,2,4-oxadiazole Analogues of Astemizole with Multi-stage Antiplasmodium Activity and <i>In Vivo</i> Efficacy in a <i>Plasmodium berghei</i> Mouse Malaria I... Autor Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon K. Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Magalhães Moreira, Lyn‐Marié Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale

    Vydáno 2022
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  6. 6
    Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

    Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box Autor Janette Reader, Mariëtte van der Watt, Dale Taylor, Claire Le Manach, Nimisha Mittal, Sabine Ottilie, Anjo Theron, Phanankosi Moyo, Erica Erlank, Luisa Nardini, Nelius Venter, Sonja B. Lauterbach, Belinda Bezuidenhout, André Horatscheck, Ashleigh van Heerden, Natalie J. Spillman, Anne N. Cowell, Jessica Connacher, Daniel Opperman, Lindsey Orchard, Manuel Llinás, Eva S. Istvan, Daniel E. Goldberg, Grant A. Boyle, David Calvo, Dalu Mancama, Thérèsa L. Coetzer, Elizabeth A. Winzeler, James Duffy, Lizette L. Koekemoer, Gregory S. Basarab, Kelly Chibale, Lyn‐Marié Birkholtz

    Vydáno 2021
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  7. 7
    The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages

    The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple <i>Plasmodium</i> kinases and life cycle stages Autor Lauren B. Arendse, James M. Murithi, Tarrick Qahash, Charisse Flerida A. Pasaje, Luiz C. Godoy, Sumanta Dey, Liezl Gibhard, Sonja Ghidelli-Disse, Gerard Drewes, Marcus Bantscheff, María José Lafuente-Monasterio, Stephen Fienberg, Lynn Wambua, Samuel Gachuhi, Dina Coertzen, Mariëtte van der Watt, Janette Reader, Ayesha S. Aswat, Erica Erlank, Nelius Venter, Nimisha Mittal, Madeline R. Luth, Sabine Ottilie, Elizabeth A. Winzeler, Lizette L. Koekemoer, Lyn‐Marié Birkholtz, Jacquin C. Niles, Manuel Llinás, David A. Fidock, Kelly Chibale

    Vydáno 2022
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  8. 8
    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria

    UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria Autor Christel Brunschwig, Nina Lawrence, Dale Taylor, Efrem Abay, Mathew Njoroge, Gregory S. Basarab, Claire Le Manach, Tanya Paquet, Diego Gonzàlez Cabrera, Aloysius T. Nchinda, Carmen De Kock, Lubbe Wiesner, Paolo Denti, David Waterson, Benjamin Blasco, Didier Leroy, Michael J. Witty, Cristina Donini, James Duffy, Sergio Wittlin, Karen L. White, Susan A. Charman, Marı́a Belén Jiménez-Dı́az, Íñigo Angulo‐Barturen, Esperanza Herreros, Francisco‐Javier Gamo, Rosemary Rochford, Dalu Mancama, Thérèsa L. Coetzer, Mariëtte van der Watt, Janette Reader, Lyn‐Marié Birkholtz, Kennan C. Marsh, Suresh Solapure, John E. Burke, Jacob A. McPhail, Manu Vanaerschot, David A. Fidock, Paul V. Fish, Peter K. S. Siegl, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Kigbafori D. Silué, Leslie J. Street, Kelly Chibale

    Vydáno 2018
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  9. 9
    Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission

    Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission Autor Paula Josefina Gómez, Anumeha Gupta, Laura Drought, Avnish Patel, John Okombo, Mariëtte van der Watt, Ryan Walker-Gray, Kyra A. Schindler, Anna Y. Burkhard, Tomas Yeo, Sunil Kumar Narwal, Talia S. Bloxham, Christian Flueck, Eloise M. Walker, Joshua A. Rey, Kate J. Fairhurst, Janette Reader, Heekuk Park, Harry Pollard, Lindsay B. Stewart, Luke Brandner-Garrod, Mojca Kristan, Geert-Jan Sterk, Youri M. van Nuland, Emilia Mańko, Donelly A. van Schalkwyk, Yang Zheng, Rob Leurs, Koen J. Dechering, Anna Caroline Campos Aguiar, Rafael V. C. Guido, Dhélio B. Pereira, Patrick K. Tumwebaze, Samuel L. Nosbya, Philip J. Rosenthal, Roland A. Cooper, Mark Palmer, Tanya Parkinson, Jeremy N. Burrows, Anne‐Catrin Uhlemann, Lyn‐Marié Birkholtz, Jennifer L. Small-Saunders, James Duffy, David A. Fidock, Alan Brown, Mark Gardner, David A. Baker

    Vydáno 2024
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  10. 10
    Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase

    Antimalarial efficacy of MMV390048, an inhibitor of <i>Plasmodium</i> phosphatidylinositol 4-kinase Autor Tanya Paquet, Claire Le Manach, Diego Gonzàlez Cabrera, Yassir Younis, Philipp P. Henrich, Tara S. Abraham, Lee M, Rajshekhar Basak, Sonja Ghidelli-Disse, María José Lafuente-Monasterio, Marcus Bantscheff, Andrea Ruecker, Andrew M. Blagborough, Sara E. Zakutansky, Anne‐Marie Zeeman, Karen L. White, David M. Shackleford, Janne Mannila, Julia Morizzi, Christian Scheurer, Íñigo Angulo‐Barturen, María Santos Martínez, Santiago Ferrer, Laura M. Sanz, Francisco‐Javier Gamo, Janette Reader, Mariëtte Botha, Koen J. Dechering, Robert W. Sauerwein, Anchalee Tungtaeng, Pattaraporn Vanachayangkul, Chek Shik Lim, Jeremy N. Burrows, Michael J. Witty, Kennan C. Marsh, Christophe Bodenreider, Rosemary Rochford, Suresh Solapure, Marı́a Belén Jiménez-Dı́az, Sergio Wittlin, Susan A. Charman, Cristina Donini, Brice Campo, Lyn‐Marié Birkholtz, Kirsten K. Hanson, Gerard Drewes, Clemens H. M. Kocken, Michael J. Delves, Didier Leroy, David A. Fidock, David Waterson, Leslie J. Street, Kelly Chibale

    Vydáno 2017
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