Resultats de la cerca - James R. Edgar

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  1. 1
    Q&A: What are exosomes, exactly?

    Q&A: What are exosomes, exactly? per James R. Edgar

    Publicat 2016
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  2. 2
    Hrs‐ and <scp>CD63</scp>‐Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

    Hrs‐ and <scp>CD63</scp>‐Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles per James R. Edgar, Emily R. Eden, Clare E. Futter

    Publicat 2013
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  3. 3
    ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular beta amyloid accumulation

    ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular beta amyloid accumulation per James R. Edgar, Katarina Willén, Gunnar K. Gouras, Clare E. Futter

    Publicat 2015
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  4. 4
    Tetherin is an exosomal tether

    Tetherin is an exosomal tether per James R. Edgar, Paul T. Manna, Shinichi Nishimura, George Banting, Margaret S. Robinson

    Publicat 2016
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  5. 5
    Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A

    Aβ accumulation causes MVB enlargement and is modelled by dominant negative VPS4A per Katarina Willén, James R. Edgar, Takafumi Hasegawa, Nobuyuki Tanaka, Clare E. Futter, Gunnar K. Gouras

    Publicat 2017
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  6. 6
    Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein–protein interactions

    Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein–protein interactions per Georg H. H. Borner, Marco Y. Hein, Jennifer Hirst, James R. Edgar, Matthias Mann, Margaret S. Robinson

    Publicat 2014
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  7. 7
    Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking

    Contributions of epsinR and gadkin to clathrin-mediated intracellular trafficking per Jennifer Hirst, James R. Edgar, Georg H. H. Borner, Sam Li, Daniela A. Sahlender, Robin Antrobus, Margaret S. Robinson

    Publicat 2015
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  8. 8
    Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting

    Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting per Paloma Navarro Negredo, James R. Edgar, Antoni G. Wrobel, Nathan R. Zaccai, Robin Antrobus, David J. Owen, Margaret S. Robinson

    Publicat 2017
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  9. 9
    OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion

    OPTN recruitment to a Golgi-proximal compartment regulates immune signalling and cytokine secretion per Thomas O’loughlin, Antonina J. Kruppa, André Luís Ribeiro Ribeiro, James R. Edgar, Abdulaziz Ghannam, Andrew Smith, Folma Buß

    Publicat 2020
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  10. 10
    Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15

    Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15 per Jennifer Hirst, Georg H. H. Borner, James R. Edgar, Marco Y. Hein, Matthias Mann, Frank Buchholz, Robin Antrobus, Margaret S. Robinson

    Publicat 2013
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  11. 11
    AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A

    AP-4 vesicles contribute to spatial control of autophagy via RUSC-dependent peripheral delivery of ATG9A per Alexandra K. Davies, Daniel N. Itzhak, James R. Edgar, Tara L. Archuleta, Jennifer Hirst, Lauren P. Jackson, Margaret S. Robinson, Georg H. H. Borner

    Publicat 2018
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  12. 12
    Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium

    Ultrastructural insight into SARS-CoV-2 entry and budding in human airway epithelium per Andreia Pinto, Ranjit Rai, Jonathan C. Brown, Paul Griffin, James R. Edgar, Anand Shah, Aran Singanayagam, Claire Hogg, William Barclay, Clare E. Futter, Thomas Burgoyne

    Publicat 2022
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  13. 13
    Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization

    Compartmentalized Synthesis of Triacylglycerol at the Inner Nuclear Membrane Regulates Nuclear Organization per António Daniel Barbosa, Koini Lim, Muriel Mari, James R. Edgar, Lihi Gal, Peter Sterk, Benjamin Jenkins, Albert Koulman, David B. Savage, Maya Schuldiner, Fulvio Reggiori, Philip A. Wigge, Symeon Siniossoglou

    Publicat 2019
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  14. 14
    Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia

    Defects in ER–endosome contacts impact lysosome function in hereditary spastic paraplegia per Rachel Allison, James R. Edgar, Guy Pearson, Tania Rizo, Timothy Mark Newton, Sven Günther, Fiamma Berner, Jennifer Hague, James W. Connell, Jürgen Winkler, Jennifer Lippincott‐Schwartz, Christian Beetz, Beate Winner, Evan Reid

    Publicat 2017
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  15. 15
    Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology

    Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology per Emma L. Clayton, Sarah Mizielinska, James R. Edgar, Troels T. Nielsen, Sarah Marshall, Frances E. Norona, Miranda Robbins, Hana Damirji, Ida E. Holm, Peter Johannsen, Jørgen E. Nielsen, Emmanuel A. Asante, John Collinge, Adrian M. Isaacs

    Publicat 2015
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  16. 16
    Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health

    Multi-omic approach characterises the neuroprotective role of retromer in regulating lysosomal health per James L. Daly, Chris M. Danson, Philip A. Lewis, Lu Zhao, Sara Riccardo, Lucio Di Filippo, Davide Cacchiarelli, Daehoon Lee, Stephen Cross, Kate J. Heesom, Wen‐Cheng Xiong, Andrea Ballabio, James R. Edgar, Peter J. Cullen

    Publicat 2023
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  17. 17
    Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease

    Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease per Jennifer Hirst, James R. Edgar, Typhaine Esteves, Frédéric Darios, Marianna Madeo, Jaerak Chang, Ricardo H. Roda, Alexandra Dürr, Mathieu Anheim, Cinzia Gellera, Jun Li, Stephan Züchner, Caterina Mariotti, Giovanni Stévanin, Craig Blackstone, Michael C. Kruer, Margaret S. Robinson

    Publicat 2015
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  18. 18
    Tetherin antagonism by <scp>SARS‐CoV</scp>‐2 <scp>ORF3a</scp> and spike protein enhances virus release

    Tetherin antagonism by <scp>SARS‐CoV</scp>‐2 <scp>ORF3a</scp> and spike protein enhances virus release per Hazel Stewart, Roberta Palmulli, K. Johansen, Naomi McGovern, Ola M. Shehata, George Carnell, Hannah K. Jackson, Jin S. Lee, Jonathan C. Brown, Thomas Burgoyne, Jonathan L. Heeney, Klaus Okkenhaug, Andrew E. Firth, Andrew A. Peden, James R. Edgar

    Publicat 2023
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  19. 19
    Complicated spastic paraplegia in patients with <i>AP5Z1</i> mutations (SPG48)

    Complicated spastic paraplegia in patients with <i>AP5Z1</i> mutations (SPG48) per Jennifer Hirst, Marianna Madeo, Katrien Smets, James R. Edgar, Lüdger Schöls, Jun Li, Anna Yarrow, Tine Deconinck, Jonathan Baets, Elisabeth Van Aken, Jan De Bleecker, Manuel B. Datiles, Ricardo H. Roda, Joachim Liepert, Stephan Züchner, Caterina Mariotti, Peter De Jonghe, Craig Blackstone, Michael C. Kruer

    Publicat 2016
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  20. 20
    A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease

    A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease per Kyungtae Lim, Eimear N Rutherford, Livia Delpiano, Peng He, Weimin Lin, Dawei Sun, Dick J. H. van den Boomen, James R. Edgar, Jae Hak Bang, Alexander V. Predeus, Sarah A. Teichmann, John C. Marioni, Lydia E. Matesic, Joo‐Hyeon Lee, Paul J. Lehner, Stefan J. Marciniak, Emma L. Rawlins, Jennifer A. Dickens

    Publicat 2025
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