Rezultati - James Doherty
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Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐fin... od Aaron Koenig, Michael Lewis, Jeff Wald, Sigui Li, Mustafa Varoglu, Jing Dai, Abdul J. Sankoh, Katrina Paumier, James Doherty, Mike Quirk
Izdano 2024Artigo -
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Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors od Manasa L. Parakala, Yihui Zhang, Amit Modgil, Jayashree Chadchankar, Thuy N. Vien, Michael A. Ackley, James Doherty, Paul Davies, Stephen J. Moss
Izdano 2019Artigo -
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SAGE-217, A Novel GABAA Receptor Positive Allosteric Modulator: Clinical Pharmacology and Tolerability in Randomized Phase I Dose-Finding Studies od Ethan Hoffmann, George G. Nomikos, Inder Kaul, Shane Raines, Jeff Wald, Amy Bullock, Abdul J. Sankoh, James Doherty, Stephen Kanes, Helen Colquhoun
Izdano 2019Artigo -
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Chemotherapeutic response to cisplatin-like drugs in human breast cancer cells probed by vibrational microspectroscopy od Ana L. M. Batista de Carvalho, Michael J. Pilling, Peter Gardner, James Doherty, Gianfelice Cinque, Katia Wehbe, Chris S. Kelley, Luís A. E. Batista de Carvalho, M. Paula M. Marques
Izdano 2016Artigo -
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Positive Allosteric Modulation as a Potential Therapeutic Strategy in Anti-NMDA Receptor Encephalitis od Natasha Warikoo, Samuel J. Brunwasser, Ann Benz, Hong‐Jin Shu, Steven M. Paul, Michael Lewis, James Doherty, Michael C. Quirk, Laura Piccio, Charles F. Zorumski, Gregory S. Day, Steven Mennerick
Izdano 2018Artigo -
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Effect of Zuranolone vs Placebo in Postpartum Depression od Kristina M. Deligiannidis, Samantha Meltzer‐Brody, Handan Gunduz‐Bruce, James Doherty, Jeffrey M. Jonas, Sigui Li, Abdul J. Sankoh, Christopher Silber, Andrew Campbell, Brian Werneburg, Stephen Kanes, Robert Lasser
Izdano 2021Artigo -
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The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of<i>N</i>-Methyl-d-Aspartate Receptors od Steven M. Paul, James Doherty, Albert J. Robichaud, Gabriel M. Belfort, Brian Y. Chow, Rebecca Hammond, Devon C. Crawford, Andrew J. Linsenbardt, Hong‐Jin Shu, Yukitoshi Izumi, Steven Mennerick, Charles F. Zorumski
Izdano 2013Artigo -
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Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis od Francesco Mannara, Marija Radosevic, Jesús Planagumà, David Soto, Esther Aguilar, Anna García‐Serra, Estibaliz Maudes, Marta Pedreño, Steven M. Paul, James Doherty, Michael C. Quirk, Jing Dai, Xavier Gasull, Michael Lewis, Josep Dalmau
Izdano 2020Artigo -
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<scp>AZD</scp>1080, a novel <scp>GSK</scp>3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans od Biljana Georgievska, Johan Sandin, James Doherty, Anette Mörtberg, Jan Neelissen, Anita Andersson, Susanne Gruber, Yvonne Nilsson, P.A. Schött, Per I. Arvidsson, Sven Hellberg, Gunilla Osswald, Stefan von Berg, Johanna Fälting, Ratan V. Bhat
Izdano 2013Artigo -
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Efficacy and safety of zuranolone co-initiated with an antidepressant in adults with major depressive disorder: results from the phase 3 CORAL study od Sagar V. Parikh, Scott T. Aaronson, Sanjay J. Mathew, Gustavo Alva, Charles DeBattista, Stephen Kanes, Robert Lasser, Amy Bullock, Mona Kotecha, JungAh Jung, Fiona Forrestal, J. Jonas, Theresa Vera, Bridgette Leclair, James Doherty
Izdano 2023Artigo -
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Trial of SAGE-217 in Patients with Major Depressive Disorder od Handan Gunduz-Bruce, Christopher Silber, Inder Kaul, Anthony J. Rothschild, Robert Riesenberg, Abdul J. Sankoh, Haihong Li, Robert Lasser, Charles F. Zorumski, David R. Rubinow, Steven M. Paul, Jeffrey M. Jonas, James Doherty, Stephen Kanes
Izdano 2019Artigo
Iskalna orodja:
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Allosteric regulation
Biochemistry
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Allosteric modulator
Pathology
Adverse effect
Alternative medicine
GABAA receptor
Genetics
Glutamate receptor
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Neuroactive steroid
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Placebo
Cell biology
Hamilton Rating Scale for Depression
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Synaptic plasticity
Allopregnanolone
Depression (economics)
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