Resultats de la cerca - Jamal Saeh

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  1. 1
    Essential role of TAK1 in regulating mantle cell lymphoma survival

    Essential role of TAK1 in regulating mantle cell lymphoma survival per Daniela Buglio, Sangeetha Palakurthi, Kate F. Byth, Francisco Vega, Dorin Toader, Jamal Saeh, Sattva S. Neelapu, Anas Younes

    Publicat 2012
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  2. 2
    Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence.

    Mechanism by which Aurora B inhibitors promotes RB and p53-dependent senescence. per Shivam Vora, Ariel Andrew, Ramyashree Prasanna Kumar, Deborah Nazareth, Madushan Fernando, Mathew V. Jones, Yaowu He, John D. Hooper, Nigel A.J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Brian Gabrielli

    Publicat 2024
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  3. 3
    Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo

    Structure and Property Based Design of Pyrazolo[1,5-a]pyrimidine Inhibitors of CK2 Kinase with Activity in Vivo per James J. Dowling, Marat Alimzhanov, Larry Bao, M. Block, Claudio Chuaqui, Emma L. Cooke, Christopher R. Denz, Alex Hird, Shan Huang, Nicholas Larsen, Bo Peng, Timothy Pontz, Caroline Rivard-Costa, Jamal Saeh, Kumar Thakur, Qing Ye, Tao Zhang, Paul D. Lyne

    Publicat 2013
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  4. 4
    Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers

    Mechanisms of Acquired Crizotinib Resistance in ALK-Rearranged Lung Cancers per Ryohei Katayama, Alice T. Shaw, Tahsin M. Khan, Mari Mino‐Kenudson, Benjamin Solomon, Balázs Halmos, Nicholas A. Jessop, John C. Wain, Alan T. Yeo, Cyril H. Benes, Lisa Drew, Jamal Saeh, Katherine Crosby, Lecia V. Sequist, A. John Iafrate, Jeffrey A. Engelman

    Publicat 2012
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  5. 5
    Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

    Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells per Shivam Vora, Saptarshi Chatterjee, Ariel Andrew, Ramyashree Prasanna Kumar, Martina Proctor, Zhen Zeng, Rituparna Bhatt, Deborah Nazareth, Madushan Fernando, Mathew V. Jones, Yaowu He, John D. Hooper, Nigel A.J. McMillan, Jelena Urosevic, Jamal Saeh, Jon Travers, Daniela Cimini, Jing Chen, Brian Gabrielli

    Publicat 2025
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  6. 6
    AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells

    AZD4573 Is a Highly Selective CDK9 Inhibitor That Suppresses MCL-1 and Induces Apoptosis in Hematologic Cancer Cells per Justin Cidado, Scott Boiko, Theresa A. Proia, Douglas Ferguson, Steven W. Criscione, Maryann San Martin, Petar Pop-Damkov, Nancy Su, Valar Nila Roamio Franklin, Chandra Sekhar Reddy Chilamakuri, Clive S. D’Santos, Wenlin Shao, Jamal Saeh, Raphael Koch, David M. Weinstock, Michael Zinda, Stephen E. Fawell, Lisa Drew

    Publicat 2019
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  7. 7
    First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma

    First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma per Erika Hamilton, Judy S. Wang, Amit M. Oza, Manish R. Patel, Susanna V. Ulahannan, Todd M. Bauer, Janet L. Karlix, Jorge Zerón-Medina, Giulia Fabbri, Paola Marco‐Casanova, Ganesh Moorthy, Maureen M. Hattersley, Gillian M. Littlewood, Patrick D. Mitchell, Jamal Saeh, Gayle P. Pouliot, Kathleen N. Moore

    Publicat 2023
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  8. 8
    A PHASE 1 FIRST-IN-HUMAN STUDY OF THE MCL-1 INHIBITOR AZD5991 IN PATIENTS WITH RELAPSED/REFRACTORY HEMATOLOGIC MALIGNANCIES

    A PHASE 1 FIRST-IN-HUMAN STUDY OF THE MCL-1 INHIBITOR AZD5991 IN PATIENTS WITH RELAPSED/REFRACTORY HEMATOLOGIC MALIGNANCIES per Pinkal Desai, Sagar Lonial, Amanda F. Cashen, Manali Kamdar, Ian W. Flinn, Susan O’Brien, Jacqueline S. Garcia, Neha Korde, Javid J. Moslehi, Margaret Wey, Patricia Cheung, Shringi Sharma, Damilola Olabode, Hong Chen, Firasath Ali Syed, Mary Liu, Jamal Saeh, Marcio Andrade‐Campos, Tapan M. Kadia, James S. Blachly

    Publicat 2024
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  9. 9
    Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial

    Safety and Tolerability of AZD0466 As Monotherapy for Patients with Advanced Hematologic Malignancies. Results from a Phase I/II Trial per Shukaib Arslan, Giovanni Marconi, Giovanni Martinelli, Shaun Fleming, Antonio Curti, Shira Dinner, James S. Blachly, Matteo Giovanni Della Porta, Ashish Bajel, Tim Sauer, Martina Crysandt, Arnaud Pigneux, Lars Fransecky, Claudia D. Baldus, Marina Konopleva, Yotvat Marmor, Shringi Sharma, Nairouz Elgeioushi, Patricia Cheung, Emily Rowe, Nikolaus Jahn, Ting Yu, Jamal Saeh, Raoul Tibes, Fathima Zumla Cader, Nitin Jain

    Publicat 2023
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  10. 10
    AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia

    AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia per Srividya B. Balachander, Steven W. Criscione, Kate F. Byth, Justin Cidado, Ammar Adam, Paula Lewis, Terry Macintyre, Shenghua Wen, Deborah Lawson, Kathleen A. Burke, Tristan Lubinski, Jeffrey W. Tyner, Stephen E. Kurtz, Shannon K. McWeeney, Jeffrey Varnes, R. Bruce Diebold, Thomas W. Gero, Stephanos Ioannidis, Edward J. Hennessy, William McCoull, Jamal Saeh, Areya Tabatabai, Omid Tavana, Nancy Su, Alwin G. Schuller, Mathew J. Garnett, Patricia Jaaks, Elizabeth A. Coker, Gareth P. Gregory, Andrea Newbold, Ricky W. Johnstone, Eric T. Gangl, Martin Wild, Michael Zinda, J. Paul Secrist, Barry R. Davies, Stephen E. Fawell, Francis D. Gibbons

    Publicat 2020
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